Journal of Renal Nutrition
Volume 11, Issue 3 , Pages 149-154 , July 2001

Serum cystatin C is an independent predictor of total homocysteine levels in stable Korean renal transplant recipients with normal serum creatinine

References 

  1. Boushey CJ, Beresford SA, Omenn GS, et al.  A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995;274:1049–1057
  2. Graham IM, Daly LE, Refsum HM, et al.  Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA. 1997;277:1775–1781
  3. Kasiske BL, Guijarro C, Massy ZA, et al.  Cardiovascular disease after renal transplantation. J Am Soc Nephrol. 1996;7:158–165
  4. Bostom AG. Homocysteine: “Expensive creatinine” or important, modifiable risk factor for arteriosclerotic outcomes in renal transplant?. J Am Soc Nephrol. 2000;11:149–151
  5. Ducloux D, Motte G, Challier B, et al.  Serum total homocysteine and cardiovascular disease occurrence in chronic, stable renal transplant recipients: A prospective study. J Am Soc Nephrol. 2000;11:134–137
  6. Selhub J, Jacques PF, Rosenberg IH, et al.  Serum total homocysteine concentrations in the Third National Health and Nutrition Examination Survey (1991-1994): Population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med. 1999;131:331–339
  7. Bostom AG, Gohh RY, Liaugaudas G, et al.  Prevalence of mild fasting hyperhomocysteinemia in renal transplant versus coronary artery disease patients after fortification of cereal grain flour with folic acid. Atherosclerosis. 1999;145:221–224
  8. Perrone RD, Madias NE, Levey AS. Serum creatinine was an index of renal function: New insight into old concepts. Clin Chem. 1992;38:1933–1953
  9. Mussap M, Ruzzante N, Varagnolo M, et al.  Quantitative automated particle-enhanced immunonephelometric assay for routinary measurement of human cyatatin C. Clin Chem Lab Med. 1998;36:859–865
  10. Norlund L, Grubb A, Fex G, et al.  The increase of plasma homocysteine concentrations with age is partly due to the deterioration of renal function as determined by plasma cyatatin C. Clin Chem Lab Med. 1998;36:175–178
  11. Lohman TG, Roche AF, Martorell R. Anthropometric Standardization Reference Manual. In: Chicago, IL: Human Kinetics; 1988;p. 3–8 39-54
  12. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high performance liquid chromatography with fluorescence detection. J Chromatogr. 1987;422:43–52
  13. Shin-Buering Y, Rasshofer R, Endres WA. A new enzymatic method for pyridoxal 5′-phosphate determination. J Inherit Metab Dis. 1981;4:123–124
  14. Horne DW, Patterson D. Lactobacillus casei assay of folic acid derivatives in 96-well microtiter plates. Clin Chem. 1988;34:2357–2359
  15. Newman DJ, Thakkar H, Edward RG, et al.  Serum cystatin C measured by automated immunoassay: A more sensitive marker of changes in GFR than serum creatinine. Kidney Int. 1995;47:312–318
  16. Korean Dietetic Association . Recommended dietary allowances for Koreans 6th Revision. 1995; Seoul, Korea,
  17. Risch L, Blumberg A, Huber A. Rapid and accurate assessment of glomerular filtration rate in patients with renal transplant using serum cystatin C. Nephrol Dial Transplant. 1999;14:1991–1996
  18. Bostom AG, Lathrop L. Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology and potential relationship to arteriosclerotic outcomes. Kidney Int. 1997;52:10–20
  19. Bostom AG, Gohh RY, Tsai M, et al.  Excess prevalence of fasting and postmethionine-loading hyperhomocysteinemia in stable renal transplant recipients. Arterioscler Thromb Vasc Biol. 1997;17:1894–1900
  20. Bostom AG, Culleton B. Hyperhomocysteinemia in chronic renal disease. Disease of the month review. J Am Soc Nephrol. 1999;10:891–900
  21. Han H, Dwyer JT, Selhub J, et al.  Determinants of plasma total homocysteine levels in Korean chronic renal transplant recipients. J Renal Nutr. 2000;10:202–207
  22. Bostom AG, Brosnan JT, Hall B, et al.  Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis. 1995;116:59–62
  23. van Guldener C, Donker AJ, Jakobs C, et al.  No net renal extraction of homocysteine in fasting humans. Kidney Int. 1998;54:166–169
  24. Bostom AG, Gohh RY, Bausserman L, et al.  Serum cystatin C as a determinant of fasting total homocysteine levels in renal transplant recipients with a normal serum creatinine. J Am Soc Nephrol. 1999;10:164–166
  25. Food standards . Amendment of standards of identity for enriched grain products to require addition of folic acid. Federal Register. March 5, 1996;61:8781–8797
  26. Beaulieu AJ, Gohh RY, Han H, et al.  Enhanced reduction of fasting total homocysteine levels with supraphysiological versus standard multivitamin dose folic acid supplementation in renal transplant recipients. Arterioscler Thromb Vasc Biol. 1999;19:2918–2921

☆ †USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, and School of Nutrition Science and Policy and Medicine, Boston, MA.

☆☆ ‡Catholic University Medical College, Kangnam St. Mary's Hospital, Seoul, Korea.

★ §Hanyang University Dept Food and Nutrition, Seoul, Korea.

★★ ∥Division of General Internal Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI.

♢ Supported by the General Clinical Research Center, the National Center for Research Resources, National Institutes of Health Grant No. MO1RR00054; the National Kidney Foundation Council on Renal Nutrition; and the United States Department of Agriculture, agreement No. 58-1950-9-001.

♢♢ Address reprint requests to Haewook Han, PhD, RD, CS, Frances Stern Nutrition Center, New England Medical Center, Box 783, 750 Washington St, Boston, MA 02111. E-mail: hhan@world.std.com.

PII: S1051-2276(01)70027-1

Journal of Renal Nutrition
Volume 11, Issue 3 , Pages 149-154 , July 2001

Article Tools