Journal of Renal Nutrition
Volume 13, Issue 1 , Pages 26-30 , January 2003

Modifications in cyclosporine (CsA) microemulsion blood concentrations by olestra

  • Cynthia J. Terrill, RD, CS, CSR

      Affiliations

    • Pediatric Renal Dietition, Intermountain Pediatric-Adolescent Renal Disease Program, University of Utah Health Sciences Center, Salt Lake City, UT.
    • ,
  • Jennifer Lill, PharmD

      Affiliations

    • Assistant Professor, Pharmacy Practice, University of Utah, College of Pharmacy, Salt Lake City, UT.
    • ,
  • K.Troy Somerville, PharmD

      Affiliations

    • Director, Clinical Research in Kidney Transplant, Solid Organ Transplantation, University of Utah, Salt Lake City, UT.
    • ,
  • Joseph R. Sherbotie, MD

      Affiliations

    • Medical Director, Pediatric Renal Transplant, Intermountain Pediatric-Adolescent Renal Disease Program, University of Utah Health Sciences Center, Salt Lake City, UT.

References 

  1. Grossman RA. Care of the renal transplant recipient: A field guide for the generalist. Dis Mon. 1998;44:269–282
  2. Hauben M. Cyclosporine neurotoxicity. Pharmacotherapy. 1996;16:576–583
  3. Jindal R. Posttransplant hyperlipidaemia. Post Grad Med J. 1997;73:785–793
  4. Sharma AK, Myers TA, Hunninghake DB, et al.  Hyperlipidemia in long-term survivors of pediatric renal transplantation. Clin Transplantation. 1994;8:252–257
  5. Everhart JE, Lombardero M, Lake JR, et al.  Weight change and obesity after liver tranplantation: incidence and risk factors. Liver Transpl Surg. 1998;4:285–296
  6. Mattson FH, Volpenhein RA. Hydrolysis of fully esterified alcohols ontaining from one to eight hydroxyl groups by the lipolitic enzymes of rat pancreatic juices. J Lipid Res. 1972;13:325–328
  7. Schlagheck TG, Riccardi KA, Zorich NL, et al.  Olestra dose response on fat-soluble and water-soluble nutrients in humans. J Nutr. 1997;127:1646S–1665S
  8. Benmoussa K, Sabouraud A, Scherrmann JM, et al.  Cyclosporine absorption is impaired by the fat substitutes, sucrose polyester and tricarballylate triester, in the rat. Pharm Res. 1994;11:1458–1461
  9. Department of Health and Human Services . Food additives permitted for direct addition to food for human consumption: olestra; final rule. Federal Register. 1996;61:3118–3172
  10. Brodehl J. Concensus statements on the optimal use of cyclosporine in pediatric patients. Transplant Proc. 1994;26:2759–2763
  11. Grevel J. Area-under-the-curve versus trough level monitoring cyclosporine concentration: Critical assessment of dosage adjustment practices and measurement of clinical outcome. Ther Drug Monit. 1993;15:488–491
  12. Sawchuck RJ, Cartier L. Liquid chromatographic determination of cyclosporin A in blood and plasma. Clin Chem. 1981;27:1368–1371
  13. Warady BA, Hebert D, Sullivan EK, et al.  Renal transplantation, chronic dialysis, and chronic renal insufficiency in children and adolescents. The 1995 annual report of the North American Pediatric Renal Transplant Cooperative Study Pediatr Nephrol. 1997;11:49–64
  14. Webb DR, Harrison GG, Lee MJ, et al.  Estimated consumption and eating frequency of olestra from savory snacks using menu census data. J Nutr. 1997;127:1546S–1554S
  15. Lindholm A, Kahan BD. Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation. Clin Pharmacol Ther. 1993;54:205–218
  16. Senel MF, Van Buren C, Welsh M, Kahan BD. Impact of early cyclosporine average blood concentration on early kidney transplant failure. Transplant Int. 1998;11:46–52

☆ Supported in part by the General Clinical Research Center, University of Utah Hospital. Funded by generous contributions from the National Kidney Foundation/Council on Renal Nutrition, Astra Clinical Pharmacy Research Award, and the University of Utah, College of Pharmacy Faculty Grants.

☆☆ Jennifer Lill is now with Department of Scientific Affairs, Berlex Laboratories.

★ Address reprint requests to Cynthia J. Terrill, RD, CS, CSR, Pediatric Renal Transplant Program, 85 North Medical Drive, East Room 201, Salt Lake City, UT 84112-5350.

PII: S1051-2276(02)13407-8

doi: 10.1053/jren.2003.50006

Journal of Renal Nutrition
Volume 13, Issue 1 , Pages 26-30 , January 2003

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