Journal of Renal Nutrition
Volume 14, Issue 2 , Pages 89-96 , April 2004

Randomized, double-blind, placebo-controlled trial to evaluate efficacy of ketodiet in predialytic chronic renal failure

  • Sunil Prakash, MD, DM (FISN)

      Affiliations

    • Head of Nephrology Division, Northern Railway Central Hospital, New Delhi, India
    • Corresponding Author InformationAddress reprint requests to Sunil Prakash, MD, 155/3 Basant Lane, Railway Colony, New Delhi 110055, India
    • ,
  • Dwarika Prasad Pande, DCH, DNB

      Affiliations

    • Incharge Division of Nutrition and Senior Pediatrician, Northern Railway Central Hospital, New Delhi, India
    • ,
  • Susham Sharma, MD

      Affiliations

    • Senior Physician, Northern Railway Central Hospital, New Delhi, India
    • ,
  • Dineshwar Sharma, MS

      Affiliations

    • Medical Director, Northern Railway Central Hospital, New Delhi, India
    • ,
  • Chandra Shekhar Bal, MD, DRM, DNB, MA

      Affiliations

    • Additional Professor, Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India
    • ,
  • Hrishikesh Kulkarni, MD

      Affiliations

    • Consultant, Surya Hospital, Pune, India

References 

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  3. Richards P, Brown CL, Houghton BJ, et al.  Synthesis of phenylalanine and valine by healthy and uremic men. Lancet. 1971;2:128–134
  4. Trevino-Becerra A, Lopez R, Alanis LM. Ketoanalogues and a very low protein diet diminish serum cholesterol in pre dialysis patients. Dial Transpl. 2002;31:25–26
  5. Klahr S, Buerkert J, Purkerson ML. Role of dietary factors in chronic renal failure. Kidney Int. 1983;24:579–587
  6. Frohling PT, Schmicker R, Veter K, et al.  Conservative treatment with ketoacid and amino acid supplemented low-protein diets in chronic renal failure. Am J Clin Nutr. 1980;33:1667–1672
  7. Mehrotra R, Nolph KD. Treatment of advanced renal failure (Low protein diets or timely initiation of dialysis?). Kidney Int. 2000;58:1381–1388
  8. Russell CD, Bischoff PG, Kontzen FN, et al.  Measurement of glomerular filtration rate (Single injection plasma clearance method without urine collection). J Nucl Med. 1985;26:1243–1247
  9. Mitch WE, Walser M, Steinman TI, et al.  The effect of a keto acid-amino acid supplement to a restricted diet on the progression of chronic renal failure. N Engl J Med. 1984;311:623–629
  10. Walser M, Hill SB, Ward L, et al.  A crossover comparison of progression of chronic renal failure (Ketocids versus amino acids). Kidney Int. 1993;43:933–939
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  12. Fouque D, Wang P, Laville H, et al.  Low protein diets delay end-stage renal disease in non-diabetic adults with chronic renal failure. Nephrol Dial Transpl. 2000;15:1986–1992
  13. Walser M, Drew HH, LaFrance ND. Creatinine measurements often yielded false estimates of progression in chronic renal failure. Kidney Int. 1988;34:412–418
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  17. Hara Y, May RC, Kelly RA, et al.  Acidosis and not azotemia, stimulates branched chain amino acid catabolism in uremic rats. Kidney Int. 1987;32:808–814
  18. Bailey JL, Wang X, England BK, et al.  The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of ATP dependent ubiquitin protease pathway. J Clin Invest. 1996;97:1447–1453
  19. Reaich D, Channon SM, Scrimgeour CM, et al.  Correction of acidosis in humans with chronic renal failure decreases protein degradation and amino acid oxidation. Am J Physiol. 1993;265:E230–E235
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  21. Klahr S, Levey AS, Beck G, et al.  The effects of dietary protein restriction and blood pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group. N Engl J Med. 1994;330:877–884
  22. Levey AS, Green T, Beck GJ, et al.  Dietary protein restriction and the progression of chronic renal disease. What have all of the results of the MDRD study shown?. J Am Soc Nephrol. 1999;10:2426–2439
  23. The GISEN Group . Randomized placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non diabetic nephropathy. Lancet. 1997;349:1857–1863
  24. Mehrotra R, Nolph KD. Argument for timely initiation of dialysis. J Am Soc Nephrol. 1998;9(suppl 12):S96–S99
  25. Traynor JP, Simpson K, Geddes CC, et al.  Initiation of dialysis fails to prolong survival in patients with end-stage renal failure. J Am Soc Nephrol. 2002;13:2125–2132
  26. Venrely B, Chauveau P, Barthe N, et al.  Nutrition in hemodialysis patients previously on a supplemented very low protein diet. Kidney Int. 2003;63:1491–1498
  27. Coresh J, Walser M, Hill S. Survival on dialysis among chronic renal failure patients treated with a supplemented low-protein diet before dialysis. J Am Soc Nephrol. 1995;6:1379–1385

PII: S1051-2276(04)00009-3

doi: 10.1053/j.jrn.2004.01.008

Journal of Renal Nutrition
Volume 14, Issue 2 , Pages 89-96 , April 2004

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