Journal of Renal Nutrition
Volume 14, Issue 3 , Pages 134-142 , July 2004

Age-related decline in serum parathyroid hormone in maintenance hemodialysis patients is independent of inflammation and dietary nutrient intake

  • Rajnish Mehrotra, MD

      Affiliations

    • Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, CA, USA
    • Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA, USA
    • Corresponding Author InformationAddress reprint requests to Rajnish Mehrotra, MD, Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA 90502 USA
    • Rajnish Mehrotra and Oupatham Supasyndh contributed equally to this work.
    • ,
  • Ouppatham Supasyndh, MD

      Affiliations

    • Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, CA, USA
    • Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA, USA
    • David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • Rajnish Mehrotra and Oupatham Supasyndh contributed equally to this work.
    • ,
  • Nancy Berman, PhD

      Affiliations

    • Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA
    • Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA, USA
    • UCLA School of Public Health, Los Angeles, CA, USA
    • ,
  • George Kaysen, MD, PhD

      Affiliations

    • Division of Nephrology, University of California, Davis, Davis, CA, USA
    • ,
  • Laura Hurst

      Affiliations

    • Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, CA, USA
    • ,
  • Michael Leonardi

      Affiliations

    • Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, CA, USA
    • ,
  • Debesh Das

      Affiliations

    • Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, CA, USA
    • ,
  • Joel D. Kopple, MD

      Affiliations

    • Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, CA, USA
    • Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA, USA
    • David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • UCLA School of Public Health, Los Angeles, CA, USA

References 

  1. Marcus R, Madvig P, Young G. Age-related changes in parathyroid hormone and parathyroid hormone action in normal humans. J Clin Endocrinol Metab. 1984;58:223–230
  2. Forero MS, Klein RF, Nissenson RA, et al.  Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women. J Bone Miner Res. 1987;2:363–366
  3. Minisola S, Pacitti MT, Scarda A, et al.  Serum ionized calcium, parathyroid hormone and related variables (Effect of age and sex). Bone Miner. 1993;23:183–193
  4. Khosla S, Atkinson EJ, Melton LJ, Riggs BL. Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women (A population-based study). J Clin Endocrinol Metab. 1997;82:1522–1527
  5. Fournier A, Yverneau PH, Hue P, et al.  Adynamic bone disease in patients with uremia. Curr Opin Nephrol Hypertens. 1994;3:396–410
  6. Pei Y, Hercz G, Greenwood C, et al.  Risk factors for renal osteodystrophy (A multivariant analysis). J Bone Miner Res. 1995;10:149–156
  7. Avram MM, Sreedhara R, Avram DK, et al.  Enrollment parathyroid hormone level is a new marker of survival in hemodialysis and peritoneal dialysis therapy for uremia. Am J Kidney Dis. 1996;28:924–930
  8. Heaf JG, Lokkegard H. Parathyroid hormone during maintenance dialysis (Influence of low calcium dialysate, plasma albumin and age). J Nephrol. 1998;11:203–210
  9. Lorenzo V, Martin M, Rufino M, et al.  Protein intake, control of serum phosphorus, and relatively low levels of parathyroid hormone in elderly hemodialysis patients. Am J Kidney Dis. 2001;37:1260–1266
  10. Fournier A, Moriniere P, Cohen SME, et al.  Adynamic bone disease in uremia (is it idiopathic? Is it an actual disease?). Nephron. 1991;58:1–12
  11. Malluche HH, Monier-Faugere MC. Risk of adynamic bone disease in dialyzed patients. Kidney Int Suppl. 1992;38:S62–S67
  12. Sherrard DJ, Hercz G, Pei Y, et al.  The spectrum of bone disease in end-stage renal failure (An evolving disorder). Kidney Int. 1993;43:436–442
  13. Hernandez D, Concepcion MT, Lorenzo V, et al.  Adynamic bone disease with negative aluminium staining in predialysis patients (prevalence and evolution after maintenance dialysis). Nephrol Dial Transplant. 1994;9:517–523
  14. Kurz P, Monier-Faugere MC, Bognar B, et al.  Evidence for abnormal calcium homeostasis in patients with adynamic bone disease. Kidney Int. 1994;46:855–861
  15. Atsumi K, Kushida K, Yamazaki K, et al.  Risk factors for vertebral fractures in renal osteodystrophy. Am J Kidney Dis. 1999;33:287–293
  16. Coco M, Rush H. Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone. Am J Kidney Dis. 2000;36:1115–1121
  17. Suliman ME, Heimburger O, Barany P, et al.  Plasma pentosidine is associated with inflammation and malnutrition in end-stage renal disease patients starting on dialysis therapy. J Am Soc Nephrol. 2003;14:1614–1622
  18. Panuccio V, Mallamaci F, Tripepi G, et al.  Low parathyroid hormone and pentosidine in hemodialysis patients. Am J Kidney Dis. 2002;40:810–815
  19. Mehrotra R, Kopple JD. Nutritional Management of Maintenance Dialysis Patients (Why aren’t we doing better?). In:  McCormick DB,  Bier DM,  Cousins RJ editor. Annual Review of Nutrition. vol 21:Palo Alto, CA: Annual Reviews; 2001;p. 343–380
  20. Andress DL, Hercz G, Kopp JB, et al.  Bone histomorphometry of renal osteodystrophy in diabetic patients. J Bone Miner Res. 1987;2:525–531
  21. Martinez I, Saracho R, Moina I, et al.  Is there a lesser hyperparathyroidism in diabetic patients with chronic renal failure?. Nephrol Dial Transplant. 1998;13:9–11

PII: S1051-2276(04)00071-8

doi: 10.1053/j.jrn.2004.05.001

Journal of Renal Nutrition
Volume 14, Issue 3 , Pages 134-142 , July 2004

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