Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 18-22 , January 2005

Regulation of skeletal muscle proteolysis by amino acids

  • Daniel Béchet, PhD

      Affiliations

    • Senior Research Associate, Human Nutrition Research Center of Clermont-Ferrand, Nutrition and Protein Metabolism Unit, INRA de Theix, Ceyrat, France.
  • ,
  • Amina Tassa, PhD

      Affiliations

    • Post-Doctoral Fellow, Human Nutrition Research Center of Clermont-Ferrand, Nutrition and Protein Metabolism Unit, INRA de Theix, 63122 Ceyrat, France. Currently: Department of Medicine, Columbia University, New York, NY USA.
  • ,
  • Lydie Combaret, PhD

      Affiliations

    • Senior Research Associate, Human Nutrition Research Center of Clermont-Ferrand, Nutrition and Protein Metabolism Unit, INRA de Theix, Ceyrat, France.
  • ,
  • Daniel Taillandier, PhD

      Affiliations

    • Senior Research Associate, Human Nutrition Research Center of Clermont-Ferrand, Nutrition and Protein Metabolism Unit, INRA de Theix, Ceyrat, France.
  • ,
  • Didier Attaix, PhD, DSc

      Affiliations

    • Research Director, Human Nutrition Research Center of Clermont-Ferrand, Nutrition and Protein Metabolism Unit, INRA de Theix, Ceyrat, France.
    • Corresponding Author InformationAddress reprint requests to Didier Attaix, PhD, INRA de Theix, Nutrition and Protein Metabolism Unit, Ceyrat, France

References 

  1. Mitch WE , Goldberg AL . Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway . N Engl J Med . 1996;335:1897–1905
  2. Attaix D , Combaret L , Kee AJ , et al.   Mechanisms of ubiquitination and proteasome-dependent proteolysis in skeletal muscle . In:  Zempleni J ,  Daniel H editor. Molecular Nutrition . Wallingford, Oxon, UK: CAB International; 2003;p. 219–235
  3. Jousse C , Averous J , Bruhat A , et al.   Amino acids as regulators of gene expression (Molecular mechanisms) . Biochem Biophys Res Commun . 2004;313:447–452
  4. Meijer AJ , Dubbelhuis PF . Amino acid signalling and the integration of metabolism . Biochem Biophys Res Commun . 2004;313:397–403
  5. Mortimore GE , Poso AR , Kadowaki M , et al.   Multiphasic control of hepatic protein degradation by regulatory amino acids. General features and hormonal modulation . J Biol Chem . 1987;262:16322–16327
  6. Mordier S , Deval C , Béchet D , et al.   Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway . J Biol Chem . 2000;275:29900–29906
  7. Tassa A , Roux MP , Attaix D , et al.   Class III phosphoinositide 3-kinase—Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes . Biochem J . 2003;376:577–586
  8. Béchet DM , Ferrara MJ , Mordier SB , et al.   Expression of lysosomal cathepsin B during calf myoblast-myotube differentiation. Characterization of a cDNA encoding bovine cathepsin B . J Biol Chem . 1991;266:14104–14112
  9. Deval C , Mordier S , Obled C , et al.   Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting . Biochem J . 2001;360:143–150
  10. Lecker SH , Jagoe RT , Gilbert A , et al.   Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression . FASEB J . 2004;18:39–51
  11. Attaix D , Combaret L , Taillandier D . Mechanisms and regulation in protein degradation . In:  Lobley GE ,  White A ,  MacRae JC editor. Protein Metabolism and Nutrition . The Netherlands: Wageningen Pers; 1999;p. 51–67
  12. Ohsumi Y . Molecular dissection of autophagy (Two ubiquitin-like systems) . Nat Rev Mol Cell Biol . 2001;2:211–216
  13. Ogier-Denis E , Pattingre S , El Benna J , et al.   Erk1/2-dependent phosphorylation of Gα-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells . J Biol Chem . 2000;275:39090–39095
  14. Petiot A , Ogier-Denis E , Blommaart EF , et al.   Distinct classes of phosphatidylinositol 3′-kinases are involved in signalling pathways that control macroautophagy in HT-29 cells . J Biol Chem . 2000;275:992–998 Erratum: J Biol Chem 275:12360, 2000
  15. Siddhanta U , McIlroy J , Shah A , et al.   Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis . J Cell Biol . 1998;143:1647–1659
  16. Medina R , Wing SS , Goldberg AL . Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy . Biochem J . 1995;307:631–637
  17. Wing SS , Haas AL , Goldberg AL . Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation . Biochem J . 1995;307:639–645
  18. Larbaud D , Balage M , Taillandier D , et al.   Differential regulation of the lysosomal, Ca2+-dependent and ubiquitin/proteasome-dependent proteolytic pathways in fast-twitch and slow-twitch rat muscle following hyperinsulinaemia . Clin Sci . 2001;101:551–558
  19. Sandri M , Sandri C , Gilbert A , et al.   FOXO transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy . Cell . 2004;117:399–412
  20. Lee SW , Dai G , Hu Z , et al.   Regulation of muscle protein degradation (Coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase) . J Am Soc Nephrol . 2004;15:1537–1545
  21. Kee AJ , Combaret L , Tilignac T , et al.   Ubiquitin-proteasome-dependent muscle proteolysis responds slowly to insulin release and refeeding in starved rats . J Physiol . 2003;546:765–776
  22. Hamel FG , Upward JL , Siford GL , et al.   Inhibition of proteasome activity by selected amino acids . Metabolism . 2003;52:810–814

 Supported by research grants from the Institut National de la Recherche Agronomique, Nestlé, and the European Society for Parenteral and Enteral Nutrition (DA). Amino Tassa was the recipient of a PhD fellowship from the French Ministry of Research and a postdoctoral fellowship from the Fondation pour la Recherche Médicale.

PII: S1051-2276(04)00162-1

doi: 10.1053/j.jrn.2004.09.005

Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 18-22 , January 2005