Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 116-120 , January 2005

Leptin, adiponectin, and ghrelin dysregulation in chronic kidney disease

  • Fitsum Guebre-Egziabher, MD

      Affiliations

    • Département de Néphrologie, Hôpital E. Herriot, Lyon, France.
    • Unité de Recherche JE 2411- Université Claude Bernard, Lyon, France.
    • ,
  • Jacques Bernhard, MD

      Affiliations

    • Département de Néphrologie, Hôpital E. Herriot, Lyon, France.
    • ,
  • Ghislaine Geelen, PhD

      Affiliations

    • Laboratoire d’Explorations Fonctionnelles Rénales et Métaboliques, Hôpital E. Herriot, Lyon, France.
    • ,
  • Etienne Malvoisin, PhD

      Affiliations

    • Laboratoire de Radioimmunoanalyse, Hôpital Edouard Herriot, Lyon, France.
    • ,
  • Aoumeur Hadj-Aissa, MD

      Affiliations

    • Laboratoire d’Explorations Fonctionnelles Rénales et Métaboliques, Hôpital E. Herriot, Lyon, France.
    • ,
  • Denis Fouque, MD, PhD

      Affiliations

    • Département de Néphrologie, Hôpital E. Herriot, Lyon, France.
    • Unité de Recherche JE 2411- Université Claude Bernard, Lyon, France.
    • Corresponding Author InformationAddress reprint requests to Denis Fouque, MD, Department of Nephrology, Hôpital E. Herriot, 69437 Lyon Cedex 03, France.

References 

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  3. Guebre-Egziabher F, Bernhard J, Funahashi T, et al: Adiponectin in chronic kidney disease is more related to metabolic disturbances rather than the decline in renal function. Nephrol Dial Transplant, 2004, in press
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  7. Stenvinkel P , Heimburger O , Lonnqvist F . Serum leptin concentrations correlate to plasma insulin concentrations independent of body fat content in chronic renal failure . Nephrol Dial Transplant . 1997;12:1321–1325
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  12. Fouque D , Geelen G , Bernhard J , et al.   Hyperleptinemia is mediated by insulin but not by renal function in pre-dialysis and kidney transplant patients . J Am Soc Nephrol . 2001;12:202; (abstr)
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  16. Weyer C , Funahashi T , Tanaka S , et al.   Hypoadiponectinemia in obesity and type 2 diabetes (Close association with insulin resistance and hyperinsulinemia) . J Clin Endocrinol Metab . 2001;86:1930–1935
  17. Kojima M , Hosoda H , Date Y , et al.   Ghrelin is a growth-hormone-releasing acylated peptide from stomach . Nature . 1999;402:656–660
  18. Batterham RL , Cohen MA , Ellis SM , et al.   Inhibition of food intake in obese subjects by peptide YY3–36 . N Engl J Med . 2003;349:941–948
  19. Woods SC . Gastrointestinal satiety signals I. An overview of gastrointestinal signals that influence food intake . Am J Physiol Gastrointest Liver Physiol . 2004;286:G7–G13
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  22. Yoshimoto A , Mori K , Sugawara A , et al.   Plasma ghrelin and desacyl ghrelin concentrations in renal failure . J Am Soc Nephrol . 2002;13:2748–2752
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  25. Huang JW , Yen CJ , Chiang HW , et al.   Adiponectin in peritoneal dialysis patients (A comparison with hemodialysis patients and subjects with normal renal function) . Am J Kidney Dis . 2004;43:1047–1055
  26. Perez-Fontan M , Cordido F , Rodriguez-Carmona A , et al.   Plasma ghrelin levels in patients undergoing haemodialysis and peritoneal dialysis . Nephrol Dial Transplant . 2004;19:2095–2100
  27. Barazzoni R , Zanetti M , Stebel M , et al.   Hyperleptinemia prevents increased plasma ghrelin concentration during short-term moderate caloric restriction in rats . Gastroenterology . 2003;124:1188–1192

 Supported in part by the University Claude Bernard, Lyon.

PII: S1051-2276(04)00172-4

doi: 10.1053/j.jrn.2004.09.015

Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 116-120 , January 2005

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