Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 137-141 , January 2005

Inflammation and resistance to treatment with recombinant human erythropoietin

  • Lucia Del Vecchio, MD

      Affiliations

    • Department of Nephrology and Dialysis, Ospedale A. Manzoni, Lecco, Italy.
    • ,
  • Pietro Pozzoni, MD

      Affiliations

    • Department of Nephrology and Dialysis, Ospedale A. Manzoni, Lecco, Italy.
    • ,
  • Simeone Andrulli, MD

      Affiliations

    • Department of Nephrology and Dialysis, Ospedale A. Manzoni, Lecco, Italy.
    • ,
  • Francesco Locatelli, MD

      Affiliations

    • Department of Nephrology and Dialysis, Ospedale A. Manzoni, Lecco, Italy.
    • Corresponding Author InformationAddress reprint requests to Francesco Locatelli, MD, Divisione di Nefrologia e Dialisi, Ospedale A. Manzoni, Via dell’Eremo 9-11, 23900 Lecco, Italy.

References 

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  2. Eschbach JW . The anemia of chronic renal failure (Pathophysiology and the effects of recombinant erythropoietin) . Kidney Int . 1989;35:134–148
  3. Locatelli F , Canaud B , Giacardy F , et al.   Treatment of anaemia in dialysis patients with unit dosing of darbepoetin alfa at a reduced dose frequency relative to recombinant human erythropoietin (rHuEpo) . Nephrol Dial Transplant . 2003;18:362–369
  4. Stenvinkel P , Heimburger O , Paultre F , et al.   Strong association between malnutrition, inflammation and atherosclerosis in chronic renal failure . Kidney Int . 1999;55:1899–1911
  5. Oberg BP , McMenamin E , Lucas FL , et al.   Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease . Kidney Int . 2004;65:1009–1016
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  7. Bárány P , Divino Filho JC , Bergström J . High C-reactive protein is a strong predictor of resistance to erythropoietin in hemodialysis patients . Am J Kidney Dis . 1997;29:565–568
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  11. Shooley JC , Kullgren B , Allison AC . Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anaemias . Br J Haematol . 1987;67:11–17
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  13. Sitter T , Bergner A , Schiffl H . Dialysate related cytokine induction and response to recombinant human erythropoietin in haemodialysis patients . Nephrol Dial Transplant . 2000;15:1207–1211
  14. Allen DA , Breen C , Yaqoob MM , et al.   Inhibition of CFU-E colony formation in uremic patients with inflammatory disease (Role of IFN-gamma and TNF-alpha) . J Investig Med . 1999;47:204–211
  15. Kalantar-Zadeh K , McAllister CJ , Lehn RS , et al.   Effect of malnutrition-inflammation complex syndrome on EPO hypo responsiveness in maintenance haemodialysis patients . Am J Kidney Dis . 2003;42:761–773
  16. Rocco MV , Paranandi L , Burrowes JD , et al.   Nutritional status in the HEMO study cohort at baseline. Hemodialysis . Am J Kidney Dis . 2002;39:245–256
  17. Owen WF , Lew NL , Liu Y , et al.   The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis . N Engl J Med . 1993;329:1001–1006
  18. Cooper BA , Penne EL , Bartlett LH , et al.   Protein malnutrition and hypoalbuminemia as predictors of vascular events and mortality in ESRD . Am J Kidney Dis . 2004;43:61–66
  19. Abbott KC , Glanton CW , Trespalacios FC , et al.   Body mass index, dialysis modality, and survival (Analysis of the United States Renal Data System Dialysis Morbidity and Mortality Wave II study) . Kidney Int . 2004;65:597–605
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  21. Stenvinkel P , Heimburger O , Paultre F , et al.   Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure . Kidney Int . 1999;55:1899–1911
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PII: S1051-2276(04)00230-4

doi: 10.1053/j.jrn.2004.09.024

Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 137-141 , January 2005

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