Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 23-27 , January 2005

Strategies for suppressing muscle atrophy in chronic kidney disease: Mechanisms activating distinct proteolytic systems

  • William E. Mitch, MD

      Affiliations

    • Department of Medicine, University of Texas Medical Branch, Galveston, TX
    • Corresponding Author InformationAddress reprint requests to William E. Mitch, MD, 4.124 John Sealy Annex, 301 University Blvd, Galveston, TX 77555-1064
    • ,
  • Zhaoyong Hu, MD

      Affiliations

    • Department of Medicine, University of Texas Medical Branch, Galveston, TX
    • ,
  • Seoung Woo Lee, MD

      Affiliations

    • Department of Medicine, University of Texas Medical Branch, Galveston, TX
    • Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University College of Medicine, Inchon, Korea
    • ,
  • Jie Du, PhD

      Affiliations

    • Department of Medicine, University of Texas Medical Branch, Galveston, TX

References 

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  2. Pickering WP , Price SR , Bircher G , et al.   Nutrition in CAPD (Serum bicarbonate and the ubiquitin-proteasome system in muscle) . Kidney Int . 2002;61:1286–1292
  3. Mansoor O , Beaufrere Y , Boirie Y , et al.   Increased mRNA levels for components of the lysosomal, Ca++-activated and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients . Proc Natl Acad Sci U S A . 1996;93:2714–2718
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  6. Lee SW , Dai G , Hu Z , et al.   Regulation of muscle protein degradation (Coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase) . J Am Soc Nephrol . 2004;15:1537–1545
  7. Bailey JL , Wang X , England BK , et al.   The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent, ubiquitin-proteasome pathway . J Clin Invest . 1996;97:1447–1453
  8. Price SR , Bailey JL , Wang X , et al.   Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome pathway by a mechanism including gene transcription . J Clin Invest . 1996;98:1703–1708
  9. Tawa NE , Odessey R , Goldberg AL . Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles . J Clin Invest . 1997;100:197–203
  10. Lecker SH , Jagoe RT , Gomes M , et al.   Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression . FASEB J . 2004;18:39–51
  11. Du J , Mitch WE , Wang X , et al.   Glucocorticoids induce proteasome C3 subunit expression in L6 muscle cells by opposing the suppression of its transcription by NF-kB . J Biol Chem . 2000;275:19661–19666
  12. Marinovic AC , Zheng B , Mitch WE , et al.   Ubiquitin expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1 . J Biol Chem . 2002;277:16673–16681
  13. Bodine SC , Latres E , Baumhueter S , et al.   Identification of ubiquitin ligases required for skeletal muscle atrophy . Science . 2001;294:1704–1708
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  15. Mitch WE , Medina R , Greiber S , et al.   Metabolic acidosis stimulates muscle protein degradation by activating the ATP-dependent pathway involving ubiquitin and proteasomes . J Clin Invest . 1994;93:2127–2133
  16. Solomon V , Goldberg AL . Importance of the ATP-ubiquitin-proteasome pathway in degradation of soluble and myofibrillar proteins in rabbit muscle extracts . J Biol Chem . 1996;271:26690–26697
  17. Du J , Wang X , Meireles CL , et al.   Activation of caspase 3 is an initial step triggering muscle proteolysis in catabolic conditions . J Clin Invest . 2004;113:115–123
  18. Mayer B , Oberbauer R . Mitochondrial regulation of apoptosis . News Physiol Sci . 2003;18:89–94
  19. Rondon-Berrios H , Workeneh B , Hu Z , et al.   A new clinical method for diagnosing accelerated muscle protein degradation in catabolic patients (The utility of the 14 kDa actin fragment in muscle) . J Am Soc Nephrol . 2004;15:837A; (abstr)
  20. Mitch WE , Bailey JL , Wang X , et al.   Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting . Am J Physiol . 1999;276:C1132–C1138
  21. Barber AJ , Nakamura M , Wolpert EB , et al.   Insulin rescues retinal neurons from apoptosis by a phosphatidyl 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3 . J Biol Chem . 2001;276:32814–32821
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  24. Stitt TN , Drujan D , Clarke BA , et al.   The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors . Mol Cell . 2004;14:395–403
  25. Bailey JL , Price SR , Mitch WE . Insulin resistance in chronic renal failure is associated with changes in the phosphatidylinositol 3-kinase (PI3K)-signaling pathway in muscle . J Am Soc Nephrol . 2002;13:522A; (abstr)
  26. Price SR , England BK , Bailey JL , et al.   Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle . Am J Physiol . 1994;267:C955–C960
  27. Hu Z , Lee SW , Du J , et al.   Critical role of glucocorticoids in activating muscle proteolysis (Regulation of caspase-3 and the ubiquitin pathway activity) . J Am Soc Nephrol . 2004;15:102A; (abstr)

PII: S1051-2276(04)00231-6

doi: 10.1053/j.jrn.2004.09.025

Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 23-27 , January 2005

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