Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 28-33 , January 2005

Amino acid and protein metabolism in chronic renal failure

  • K. Sreekumaran Nair, MD, PhD

      Affiliations

    • Mayo Clinic College of Medicine, Rochester, MN
    • Corresponding Author InformationAddress reprint requests to K. Sreekumaran Nair, MD, PhD, Mayo Clinic College of Medicine, 200 First St SW, 5-194 Joseph, Rochester, MN 55905

References 

  1. Owen OE , Felig P , Morgan AP , et al.   Liver and kidney metabolism during prolonged starvation . J Clin Invest . 1969;48:574–583
  2. Moller N , Rizza RA , Ford GC , et al.   Assessment of postabsorptive renal glucose metabolism in humans with multiple glucose tracers . Diabetes . 2001;50:747–751
  3. Ekberg K , Landau BR , Wajngot A , et al.   Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting . Diabetes . 1999;48:292–298
  4. Stumvoll M , Meyer C , Mitrakou A , et al.   Renal glucose production and utilization (New aspects in humans) . Diabetologia . 1997;40:749–757
  5. Cersosimo E , Judd RL , Miles JM . Insulin regulation of renal glucose metabolism in conscious dogs . J Clin Invest . 1994;93:2584–2589
  6. Cersosimo E , Garlick P , Ferretti J . Insulin regulation of renal glucose metabolism in humans . Am J Physiol . 1999;276:E78–E84
  7. Tessari P , Garibotto G , Inchiostro S , et al.   Kidney, splanchnic, and leg protein turnover in humans (Insight from phenylalanine kinetics) . J Clin Invest . 1996;98:1481–1492
  8. Moller N , Meek S , Bigelow M , et al.   The kidney is an important site for in vivo phenylalanine-to-tyrosine conversion in adult humans (A metabolic role of the kidney) . Proc Natl Acad Sci U S A . 2000;97:1242–1246
  9. Boirie Y , Albright RA , Bigelow M , et al.   Impairment of phenylalanine conversion to tyrosine in end-stage renal disease causing tyrosine deficiency . Kidney Int . 2004;66:1–6
  10. Greiber S , Mitch WE . Mechanisms for protein catabolism in uremia (Metabolic acidosis and activation of proteolytic pathways) . Miner Electrolyte Metab . 1992;18:233–236
  11. Bailey JL , Wang X , England BK , et al.   The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway . J Clin Invest . 1996;97:1447–1453
  12. Mitch WE , Clark AS . Muscle protein turnover in uremia . Kidney Int . 1983;16(suppl 16):S2–S8
  13. Adey D , Kumar R , McCarthy JT , et al.   Reduced synthesis of muscle proteins in chronic renal failure . Am J Physiol . 2000;278:E219–E225
  14. Durozard D , Pimmel P , Baretto S , et al.   31P NMR spectroscopy investigation of muscle metabolism in hemodialysis patients . Kidney Int . 1993;43:885–892
  15. Hsieh MC , Berry HK . Distribution of phenylalanine hydroxylase (EC 1.14.3.1) in liver and kidney of vertebrates . J Exp Zoolog . 1979;208:161–167
  16. Ayling JE , Pirson WD , Al-Janabi JM , et al.   Kidney phenylalanine hydroxylase from man and rat (Comparison with the liver enzyme) . Biochemistry . 1974;13:78–85
  17. Tessari P , Deferrari G , Robaudo C , et al.   Phenylalanine hydroxylation across the kidney in humans . Kidney Int . 1999;56:2168–2172
  18. Du J , Wang X , Miereles C , et al.   Activation of caspase 3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions . J Clin Invest . 2004;113:115–123
  19. Barazzoni R , Short KR , Nair KS . Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart . J Biol Chem . 2000;275:3343–3347
  20. Rooyackers OE , Adey DB , Ades PA , et al.   Effect of age in vivo rates of mitochondrial protein synthesis in human skeletal muscle . Proc Natl Acad Sci U S A . 1996;93:15364–15369
  21. Campisi J . Aging, chromatin, and food restriction—Connecting the dots . Science . 2000;289:2062–2063
  22. Balagopal P , Rooyackers OE , Adey DB , et al.   Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans . Am J Physiol . 1997;273:E790–E800
  23. Short KR , Vittone J , Bigelow ML , et al.   Age and aerobic exercise training effects on whole body and muscle protein metabolism . Am J Physiol Endocrinol Metab . 2004;286:E92–E101

 Studies performed in this manuscript are supported by the National Institutes of Health (R01 DK41973, R01 AG09531, General Clinical Research Center grant M01 RR00585).

PII: S1051-2276(04)00232-8

doi: 10.1053/j.jrn.2004.09.026

Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 28-33 , January 2005