Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 2-7 , January 2005

Haplotype analysis of carnitine transporters and left ventricular mass in human essential hypertension

  • Grazia Tripodi, BSc

      Affiliations

    • Prassis-Sigma Tau Research Institute, Settimo Milanese, Milano, Italy.
    • Corresponding Author InformationAddress reprint requests to Grazia Tripodi, BSc, Prassis-Sigma Tau Research Institute, Via Forlanini, 1, 20029 Settimo Milanese, Milano, Italy.
    • ,
  • Rossana Modica

      Affiliations

    • Prassis-Sigma Tau Research Institute, Settimo Milanese, Milano, Italy.
    • ,
  • Alessandra Stella, PhD

      Affiliations

    • Research Center Institute of Biology and Biotechnology of Agronomy-Consiglio Nazionale della Ricerche, Milano, Italy.
    • ,
  • Giada Bigatti, MD

      Affiliations

    • Division of Nephrology, Dialysis and Hypertension University Vita-Salute, Istituto di Ricovero e Cura a Carattere Scientifico San Raffalele Hospital, Milano, Italy.
    • ,
  • Giuseppe Bianchi, MD

      Affiliations

    • Division of Nephrology, Dialysis and Hypertension University Vita-Salute, Istituto di Ricovero e Cura a Carattere Scientifico San Raffalele Hospital, Milano, Italy.
    • ,
  • Paola Stella, MD

      Affiliations

    • Division of Nephrology, Dialysis and Hypertension University Vita-Salute, Istituto di Ricovero e Cura a Carattere Scientifico San Raffalele Hospital, Milano, Italy.

References 

  1. Levy D , Garrison RJ , Savage DD , et al.   Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study . N Engl J Med . 1990;322:1561–1566
  2. Lauer MS , Evans JC , Levi D . Prognostic implications of subclinical left ventricular dilatation and systolic dysfunction in men free of overt cardiovascular disease (the Framingham Heart study) . Am J Cardiol . 1992;70:1180–1184
  3. Schunkert H , Brockel U , Hengstenberg C , et al.   Familial predisposition of left ventricular hypertophy . J Am Coll Cardiol . 1999;33:1685–1691
  4. De Las Fuentes L , Herrero P , Peterson LR , et al.   Myocardial fatty acid metabolism (Independent predictor of left ventricular mass in hypertensive heart disease) . Hypertension . 2003;41:83–87
  5. Tein I . Role of carnitine and fatty acid oxidation and its defects in infantile epilepsy . J Child Neurol . 2002;3:S57–S83
  6. Nakamura T , Sugihara H , Kinoshita N , et al.   Can serum carnitine levels distinguish hypertrophic cardiomyopathy from hypertensive hearts? . Hypertension . 2000;36:215–219
  7. Kelly DP , Strauss AW . Inherited cardiomyopathies . N Engl J Med . 1994;330:913–919
  8. Kerner J , Hoppel C . Genetic disorders of carnitine metabolism and their nutritional management . Annu Rev Nutr . 1998;18:179–206
  9. Nezu J , Tamai I , Oku A , et al.   Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter . Nat Genet . 1999;21:91–94
  10. Stella P , Bigatti G , Tizzoni L , et al.   Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension . J Am Coll Cardiol . 2004;43:265–270
  11. Devereux RB , Alonso DR , Lutas EM , et al.   Echocardiographic assessment of left ventricular hypertrophy (Comparison to necropsy findings) . Am J Cardiol . 1986;57:450–458
  12. Stephens M , Smith NJ , Donnelly P . A new statistical method for haplotype reconstruction from population data . Am J Hum Genet . 2001;68:978–989
  13. Judson RS , Stephens JC , Windemuth A . The predictive power of haplotype analysis in clinical response . Pharmacogenomics . 2000;1:15–26
  14. Daly MJ , Rioux JD , Schaffen SE , et al.   High- resolution haplotype structure in the human genome . Nat Genet . 2001;29:229–237
  15. Zhao H , Pfeiffer R , Gail MH . Haplotype analysis in population genetics and association studies . Pharmacogenomics . 2003;4:171–178

PII: S1051-2276(04)00241-9

doi: 10.1053/j.jrn.2004.09.035

Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 2-7 , January 2005

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