Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 125-130 , January 2005

Adipose tissue cytokines, insulin sensitivity, inflammation, and cardiovascular outcomes in end-stage renal disease patients

  • Carmine Zoccali, MD

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • Corresponding Author InformationAddress reprint requests to Carmine Zoccali, Ospedali Riuniti, Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Opsedale Riuniti, Via Vallone Petrara, Reggio Calabria, 89124 Italy.
    • ,
  • Giovanni Tripepi

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Francesco Cambareri, MD

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Francesco Catalano, MD

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Pietro Finocchiaro, MD

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Sebastiano Cutrupi

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Patrizia Pizzini

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Alessandra Testa

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Belinda Spoto

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Vincenzo Panuccio, MD

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Giuseppe Enia, MD

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.
    • ,
  • Francesca Mallamaci, MD

      Affiliations

    • Consiglio Nazionale Ricerche–Istituto BIo Medicina (CNR-IBIM) Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell’Ipertensione Arteriosa, Reggio Calabria, Italy.

References 

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  2. Zoccali C , Mallamaci F , Tripepi G . Adipose tissue as a source of inflammatory cytokines in health and disease (Focus on end-stage renal disease) . Kidney Int Suppl . 2003;84:S65–S658
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  7. Hotta K , Funahashi T , Bodkin NL , et al.   Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys . Diabetes . 2001;50:1126–1133
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  9. Ouchi N , Kihara S , Arita Y , et al.   Novel modulator for endothelial adhesion molecules (Adipocyte-derived plasma protein adiponectin) . Circulation . 1999;100:2473–2476
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  11. Dumler F , Kilates C . Body composition analysis by bioelectrical impedance in chronic maintenance dialysis patients (Comparisons to the National Health and Nutrition Examination Survey III) . J Ren Nutr . 2003;13:166–172
  12. Zoccali C , Mallamaci F , Benedetto FA , et al.   Cardiac natriuretic peptides are related to left ventricular mass and function and predict mortality in dialysis patients . J Am Soc Nephrol . 2001;12:1508–1515
  13. Zhao AZ , Bornfeldt KE , Beavo JA . Leptin inhibits insulin secretion by activation of phosphodiesterase 3B . J Clin Invest . 1998;102:869–873
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  15. Don BR , Rosales LM , Levine NW , et al.   Leptin is a negative acute phase protein in chronic hemodialysis patients . Kidney Int . 2001;59:1114–1120
  16. Pecoits-Filho R , Nordfors L , Heimbürger O , et al.   Soluble leptin receptors and serum leptin in end-stage renal disease (Relationship with inflammation and body composition) . Eur J Clin Invest . 2002;11:811–817
  17. Zimmermann J , Herrlinger S , Pruy A , et al.   Inflammation enhances cardiovascular risk and mortality in hemodialysis patients . Kidney Int . 1999;55:648–658
  18. Tripepi G , Mallamaci F , Zoccali C . Inflammation markers, adhesion molecules and all cause and cardiovascular mortality in patients with ESRD. Searching for the best risk marker by multivariate modeling . J Am Soc Nephrology . 2004; in press
  19. Vasseur F , Helbecque N , Dina C , et al.   Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians . Hum Mol Genet . 2002;11:2607–2614
  20. Zoccali C , Mallamaci F , Tripepi G , et al.   Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease . J Am Soc Nephrol . 2002;13:134–141
  21. Stenvinkel P , Marchlewska A , Pecoits-Filho R , et al.   Adiponectin in renal disease (Relationship to phenotype and genetic variation in the gene encoding adiponectin) . Kidney Int . 2004;65:274–281
  22. Huang JW , Yen CJ , Chiang HW , et al.   Adiponectin in peritoneal dialysis patients (A comparison with hemodialysis patients and subjects with normal renal function) . Am J Kidney Dis . 2004;43:1047–1055
  23. Iwashima Y , Katsuya T , Ishikawa K , et al.   Hypoadiponectinemia is an independent risk factor for hypertension . Hypertension . 2004;43:1318–1323
  24. Tan KC , Xu A , Chow WS , et al.   Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation . J Clin Endocrinol Metab . 2004;89:765–769

PII: S1051-2276(04)00242-0

doi: 10.1053/j.jrn.2004.09.036

Journal of Renal Nutrition
Volume 15, Issue 1 , Pages 125-130 , January 2005

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