Journal of Renal Nutrition
Volume 15, Issue 2 , Pages 231-243 , April 2005

The Nutritional and Inflammatory Evaluation in Dialysis patients (NIED) study: Overview of the NIED study and the role of dietitians

  • Sara Colman, RD, CSR, CDE

      Affiliations

    • DaVita, Norwalk, CA
    • ,
  • Rochelle Bross, MS, RD, PhD

      Affiliations

    • Harbor-UCLA General Clinical Research Center, Torrance, CA
    • ,
  • Debbie Benner, MA, RD, CSR

      Affiliations

    • DaVita National Director Nutrition Services, Irvine, CA
    • ,
  • Joanne Chow, RD

      Affiliations

    • Harbor-UCLA DaVita, Torrance, CA
    • ,
  • Amy Braglia, RD

      Affiliations

    • Harbor-UCLA DaVita, Torrance, CA
    • ,
  • Jenia Arzaghi, RD

      Affiliations

    • Harbor-UCLA DaVita, Torrance, CA
    • ,
  • Jennifer Dennis, MS, RD

      Affiliations

    • DaVita Premier, Cudahy, CA
    • ,
  • Leslie Martinez, RD

      Affiliations

    • DaVita Kenneth Hahn Plaza, Los Angeles, CA
    • ,
  • Delma Baylon Baldo, RD

      Affiliations

    • DaVita Lakewood, Lakewood, CA
    • ,
  • Vina Agarwal, RD

      Affiliations

    • DaVita Kidney Dialysis Center, Lynwood, CA
    • ,
  • Tina Trundnowski, RD

      Affiliations

    • DaVita Sunrise Dialysis, Hawthorne, CA
    • ,
  • Jennifer Zitterkoph, RD

      Affiliations

    • Harbor-UCLA General Clinical Research Center, Torrance, CA
    • ,
  • Brenda Martinez

      Affiliations

    • NIED Study Center, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA
    • ,
  • Osman S. Khawar, MD

      Affiliations

    • NIED Study Center, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA
    • ,
  • Kamyar Kalantar-Zadeh, MD, PhD, MPH

      Affiliations

    • NIED Study Center, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA
    • Corresponding Author InformationAddress reprint requests to Kamyar Kalantar-Zadeh, MD, PhD, MPH, Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Harbor Mailbox 406, 1000 West Carson St, Torrance, CA 90509-2910

References 

  1. United States Renal Data System: US Department of Public Health and Human Services . Bethesda, MD: Public Health Service, National Institutes of Health; 2002;
  2. System USRD: USRD 2003 Annual Data Report; Atlas of End Stage Renal Diseases in the United States . Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2003;
  3. Morbidity and mortality of dialysis (NIH Consens Statement) . 1993;11:1–33
  4. Foley RN , Parfrey PS , Sarnak MJ . Clinical epidemiology of cardiovascular disease in chronic renal disease . Am J Kidney Dis . 1998;32:S112–S119
  5. Eknoyan G , Beck GJ , Cheung AK , et al.   Effect of dialysis dose and membrane flux in maintenance hemodialysis . N Engl J Med . 2002;347:2010–2019
  6. Paniagua R , Amato D , Vonesh E , et al.   Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis (ADEMEX, a prospective, randomized, controlled trial) . J Am Soc Nephrol . 2002;13:1307–1320
  7. Kalantar-Zadeh K , Block G , Humphreys MH , et al.   Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients . Kidney Int . 2003;63:793–808
  8. Nishizawa Y , Shoji T , Ishimura E , et al.   Paradox of risk factors for cardiovascular mortality in uremia (Is a higher cholesterol level better for atherosclerosis in uremia?) . Am J Kidney Dis . 2001;38:S4–S7
  9. Fleischmann EH , Bower JD , Salahudeen AK . Risk factor paradox in hemodialysis (Better nutrition as a partial explanation) . ASAIO J . 2001;47:74–81
  10. Salahudeen AK . Obesity and survival on dialysis . Am J Kidney Dis . 2003;41:925–932
  11. Kalantar-Zadeh K , Kilpatrick RD , Kuwae N , et al.   Reverse epidemiology (A spurious hypothesis or a hardcore reality?) . Blood Purif . 2005;23:57–63
  12. Kopple JD . Nutritional status as a predictor of morbidity and mortality in maintenance dialysis patients . ASAIO J . 1997;43:246–250
  13. Fung F , Sherrard DJ , Gillen DL , et al.   Increased risk for cardiovascular mortality among malnourished end-stage renal disease patients . Am J Kidney Dis . 2002;40:307–314
  14. Kalantar-Zadeh K , Ikizler TA , Block G , et al.   Malnutrition-inflammation complex syndrome in dialysis patients (Causes and consequences) . Am J Kidney Dis . 2003;42:864–881
  15. Kalantar-Zadeh K , Kopple JD . Relative contributions of nutrition and inflammation to clinical outcome in dialysis patients . Am J Kidney Dis . 2001;38:1343–1350
  16. Bergstrom J . Inflammation, malnutrition, cardiovascular disease and mortality in end- stage renal disease . Pol Arch Med Wewn . 2000;104:641–643
  17. Qureshi AR , Alvestrand A , Divino-Filho JC , et al.   Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients . J Am Soc Nephrol . 2002;13(suppl 1):S28–S36
  18. Stenvinkel P . Malnutrition and chronic inflammation as risk factors for cardiovascular disease in chronic renal failure . Blood Purif . 2001;19:143–151
  19. Stenvinkel P , Chung SH , Heimburger O , et al.   Malnutrition, inflammation, and atherosclerosis in peritoneal dialysis patients . Perit Dial Int . 2001;21(suppl 3):S157–S162
  20. Ifudu O , Uribarri J , Rajwani I , et al.   Low hematocrit may connote a malnutrition-inflammation syndrome in hemodialysis patients . Dial Transplant . 2002;31:845–878
  21. Kalantar-Zadeh K , McAllister CJ , Lehn RS , et al.   Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patients . Am J Kidney Dis . 2003;42:761–773
  22. Kalantar-Zadeh K , Kopple JD , Block G , et al.   Association among SF36 quality of life measures and nutrition, hospitalization, and mortality in hemodialysis . J Am Soc Nephrol . 2001;12:2797–2806
  23. Diaz-Buxo JA , Lowrie EG , Lew NL , et al.   Quality-of-life evaluation using Short Form 36 (Comparison in hemodialysis and peritoneal dialysis patients) . Am J Kidney Dis . 2000;35:293–300
  24. Kalantar-Zadeh K , Bross R , Zitterkoph J , et al.   Comparing four body composition assessment methods for body fat measurement in dialysis patients. 37th annual conference of the American Society of Nephrology . J Am Soc Nephrol . 2004;15(abstr, suppl):591A
  25. Kalantar-Zadeh K , Block G , McAllister CJ , et al.   Appetite and inflammation, nutrition, anemia and clinical outcome in hemodialysis patients . Am J Clin Nutr . 2004;1:299–307
  26. Kalantar-Zadeh K , McAllister CJ , Lehn RS , et al.   A low serum iron level is a predictor of poor outcome in hemodialysis patients . Am J Kidney Dis . 2004;43:671–684
  27. Kalantar-Zadeh K , Kopple JD , Humphreys MH , et al.   Comparing outcome predictability of markers of malnutrition-inflammation complex syndrome in haemodialysis patients . Nephrol Dial Transplant . 2004;19:1507–1519
  28. Kalantar-Zadeh K , Block G , Humphreys MH , et al.   A low, rather than a high, total plasma homocysteine is an indicator of poor outcome in hemodialysis patients . J Am Soc Nephrol . 2004;15:442–453
  29. Brennan ML , Penn MS , Van Lente F , et al.   Prognostic value of myeloperoxidase in patients with chest pain . N Engl J Med . 2003;349:1595–1604
  30. Ansell BJ , Navab M , Hama S , et al.   Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment . Circulation . 2003;108:2751–2756
  31. Kalantar-Zadeh K , Kopple JD , Block G , et al.   A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients . Am J Kidney Dis . 2001;38:1251–1263
  32. Nelson EE , Hong CD , Pesce AL , et al.   Anthropometric norms for the dialysis population . Am J Kidney Dis . 1990;16:32–37
  33. Williams AJ , McArley A . Body composition, treatment time, and outcome in hemodialysis patients . J Ren Nutr . 1999;9:157–162
  34. Steiber AL , Kalantar-Zadeh K , Secker D , et al.   Subjective Global Assessment in chronic kidney disease (A review) . J Ren Nutr . 2004;14:191–200
  35. Kalantar-Zadeh K , Fouque D , Kopple JD . Outcome research, nutrition, and reverse epidemiology in maintenance dialysis patients . J Ren Nutr . 2004;14:64–71
  36. Kalantar-Zadeh K , Dunne E , Nixon K , et al.   Near infra-red interactance for nutritional assessment of dialysis patients . Nephrol Dial Transplant . 1999;14:169–175
  37. Kalantar-Zadeh K , Block G , Kelly MP , et al.   Near infra-red interactance for longitudinal assessment of nutrition in dialysis patients . J Ren Nutr . 2001;11:23–31
  38. Flagg EW , Coates RJ , Eley JW , et al.   Dietary glutathione intake in humans and the relationship between intake and plasma total glutathione level . Nutr Cancer . 1994;21:33–46
  39. Block G , Norkus E , Hudes M , et al.   Which plasma antioxidants are most related to fruit and vegetable consumption? . Am J Epidemiol . 2001;154:1113–1118
  40. Kalantar-Zadeh K , Kopple JD , Deepak S , et al.   Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire . J Ren Nutr . 2002;12:17–31
  41. Dumler F . Use of bioelectric impedance analysis and dual-energy X-ray absorptiometry for monitoring the nutritional status of dialysis patients . ASAIO J . 1997;43:256–260
  42. Woodrow G , Oldroyd B , Smith MA , et al.   Measurement of body composition in chronic renal failure (comparison of skinfold anthropometry and bioelectrical impedance with dual energy X- ray absorptiometry) . Eur J Clin Nutr . 1996;50:295–301
  43. Woodrow G , Oldroyd B , Turney JH , et al.   Whole body and regional body composition in patients with chronic renal failure . Nephrol Dial Transplant . 1996;11:1613–1618
  44. Chertow GM , Lowrie EG , Wilmore DW , et al.   Nutritional assessment with bioelectrical impedance analysis in maintenance hemodialysis patients . J Am Soc Nephrol . 1995;6:75–81
  45. Qureshi AR , Alvestrand A , Danielsson A , et al.   Factors predicting malnutrition in hemodialysis patients (A cross-sectional study) . Kidney Int . 1998;53:773–782
  46. Stenvinkel P , Barany P , Chung SH , et al.   A comparative analysis of nutritional parameters as predictors of outcome in male and female ESRD patients . Nephrol Dial Transplant . 2002;17:1266–1274
  47. Fried L , Bernardini J , Piraino B . Charlson comorbidity index as a predictor of outcomes in incident peritoneal dialysis patients . Am J Kidney Dis . 2001;37:337–342
  48. Beddhu S , Bruns FJ , Saul M , et al.   A simple comorbidity scale predicts clinical outcomes and costs in dialysis patients . Am J Med . 2000;108:609–613
  49. Shinaberger CS , Kilpatrick RD , McAllister CJ , et al.   Exploring time-dependent associations between urea dynamic calculated protein intake and cardiovascular mortality in hemodialysis patients (37th annual conference of the American Society of Nephrology) . J Am Soc Nephrol . 2004;15(abstr, suppl):385A–386A
  50. Kilpatrick RD , Greenland S , McAllister CJ , et al.   Time-dependent association between dialysis dose and cardiovascular mortality in hemodialysis patients (37th annual conference of the American Society of Nephrology) . J Am Soc Nephrol . 2004;15(abstr, suppl):2A–3A
  51. Kalantar-Zadeh K , Kilpatrick RD , McAllister CJ , et al.   Time-dependant association between body mass index and cardiovascular mortality in hemodialysis patients (37th annual conference of the American Society of Nephrology) . J Am Soc Nephrol . 2004;15(abstr, suppl):126A
  52. Daneker B , Kimmel PL , Ranich T , et al.   Depression and marital dissatisfaction in patients with end-stage renal disease and in their spouses . Am J Kidney Dis . 2001;38:839–846
  53. Szabo E , Moody H , Hamilton T , et al.   Choice of treatment improves quality of life (A study on patients undergoing dialysis) . Arch Intern Med . 1997;157:1352–1356
  54. Moreno F , Aracil FJ , Perez R , et al.   Controlled study on the improvement of quality of life in elderly hemodialysis patients after correcting end-stage renal disease-related anemia with erythropoietin . Am J Kidney Dis . 1996;27:548–556
  55. Mapes DL , Lopes AA , Satayathum S , et al.   Health-related quality of life as a predictor of mortality and hospitalization (the Dialysis Outcomes and Practice Patterns study (DOPPS)) . Kidney Int . 2003;64:339–349
  56. Kutner NG , Zhang R , McClellan WM . Patient-reported quality of life early in dialysis treatment (Effects associated with usual exercise activity) . Nephrol Nurs J . 2000;27:357–367 discussion 368, 424
  57. Kalantar-Zadeh K , Lehn RS , McAllister CJ , et al.   Impact of malnutrition-inflammation complex syndrome and ACE-inhibitors on erythropoietin hyporesponsiveness in hemodialysis patients . J Am Soc Nephrol . 2002;13(abstr SU-P0557, suppl):582A
  58. Kalantar-Zadeh K , Rodriguez R , Kelly M , et al.   Cuffed dialysis catheter and hepatitis C are associated with malnutrition in hemodialysis patients . J Am Soc Nephrol . 1999;10(abstr A1245, suppl):246A
  59. Kalantar-Zadeh K , Humphreys MH , Kopple JD . Association between type of dialysis access and quality of life in maintenance hemodialysis patients . J Am Soc Nephrol . 2002;13(abstr SA-P0649, suppl):396A
  60. Kalantar-Zadeh K , Supasyndh O , Lehn RS , et al.   Normalized protein nitrogen appearance is correlated with hospitalization and mortality in hemodialysis patients with Kt/V greater than 1.20 . J Ren Nutr . 2003;13:15–25
  61. Kuwae N , Kopple J , Kalantar-Zadeh K . A low lymphocyte count is a predictor of mortality and hospitalization in hemodialysis patients . Clin Nephrology . 2005;63:22–34
  62. Kalantar-Zadeh K , Horwich TB , Fonarow GC , et al.   A low, rather than a high, serum LDL cholesterol is associated with increased mortality in hemodialysis patients even after controlling for inflammation (37th annual conference of the American Society of Nephrology) . J Am Soc Nephrol . 2004;15(abstr, suppl):173A
  63. Kalantar-Zadeh K , Brennan ML . Serum myeloperoxidase measurement and its correlates in maintenance hemodialysis patients (37th annual conference of the American Society of Nephrology) . J Am Soc Nephrol . 2004;15(abstr, suppl):173A
  64. Kalantar-Zadeh K , Kamranpour N , Kopple JD . Association between novel HDL inflammatory/anti-inflammatory properties with body mass index in hemodialysis patients (37th annual conference of the American Society of Nephrology) . J Am Soc Nephrol . 2004;15(abstr, suppl):172A
  65. Kalantar-Zadeh K , Bross R , Takasu J , et al.   Associations between markers of malnutrition-inflammation complex syndrome and anemia and coronary artery calcification in hemodialysis patients (37th annual conference of the American Society of Nephrology) . J Am Soc Nephrol . 2004;15(abstr, suppl):383A
  66. Kopple JD , Greene T , Chumlea WC , et al.   Relationship between nutritional status and the glomerular filtration rate (Results from the MDRD study) . Kidney Int . 2000;57:1688–1703
  67. Levey AS , Greene T , Schluchter MD , et al.   Glomerular filtration rate measurements in clinical trials (Modification of Diet in Renal Disease Study Group and the Diabetes Control and Complications Trial Research Group) . J Am Soc Nephrol . 1993;4:1159–1171
  68. Vonesh E , Schaubel D , Hao W , et al.   Statistical methods for comparing mortality among ESRD patients (Examples of regional/international variations) . Kidney Int . 2000;57:19–27

 The NIED study is supported by a grant from the National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK) of the National Institutes of Health (DK61162); a research grant from Amgen, Inc; a research grant from DaVita, Inc; and a General Clinical Research Center (GCRC) grant (M01-RR00425) from the National Centers for Research Resources, National Institutes of Health.

PII: S1051-2276(05)00004-X

doi: 10.1053/j.jrn.2005.01.003

Journal of Renal Nutrition
Volume 15, Issue 2 , Pages 231-243 , April 2005

Article Tools

* Image Usage & Resolution