Journal of Renal Nutrition
Volume 16, Issue 2 , Pages 119-124 , April 2006

Effect of High-Dose Thiamine and Pyridoxine on Advanced Glycation End Products and Other Oxidative Stress Markers in Hemodialysis Patients: A Randomized Placebo-Controlled Study

  • Marcelo M. Nascimento, MD, PhD

      Affiliations

    • Faculdade Evangélica do Paraná-Brazil, Paraná, Brazil
    • Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    • Corresponding Author InformationAddress reprint requests to Marcelo Mazza do Nascimento, MD, PhD, Department of Nephrology, Evangelic Medical School, Curitiba, Paraná, Brazil
    • ,
  • Mohamed E. Suliman, MD, PhD

      Affiliations

    • Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    • ,
  • Yukio Murayama, MD

      Affiliations

    • Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    • ,
  • Melissa Nihi, RD

      Affiliations

    • Faculdade Evangélica do Paraná-Brazil, Paraná, Brazil
    • ,
  • Shirley Y. Hayashi, MD

      Affiliations

    • Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    • ,
  • Peter Stenvinkel, MD, PhD

      Affiliations

    • Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    • ,
  • Miguel C. Riella, MD, PhD

      Affiliations

    • Faculdade Evangélica do Paraná-Brazil, Paraná, Brazil
    • ,
  • Bengt Lindholm, MD, PhD

      Affiliations

    • Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

References 

  1. Sell D , Monnier V . Structure elucidation of a senescence cross link from human extracellular matrix. Implication of pentoses in the aging process . J Biol Chem . 1989;264:597–602
  2. Wells-Knecht K , Brinkmann E , Wells-Knecht M , et al.   New biomarkers of Maillard reaction damage to patients . Nephrol Dial Transplant . 1996;11:41–47
  3. Raj D , Choudhury D , Welbourne T , et al.   Advanced glycation end products (A Nephrologist’s perspective) . Am J Kidney Dis . 2000;35:365–380
  4. Kalousova M , Zima T , Tesar V , et al.   Advanced glycation end products in clinical nephrology . Kidney Blood Press Res . 2004;27:18–28
  5. Thornalley PJ . Glycation in diabetic neuropathy (Characteristics, consequences, causes, and therapeutic options) . Int Rev Neurobiol . 2002;50:37–57
  6. Booth AA , Khalifah RG , Todd P , et al.   In vitro kinetic studies of formation of antigenic advanced glycation end products (AGEs). Novel inhibition of post-Amadori glycation pathways . J Biol Chem . 1997;272:5430–5437
  7. La Selva M , Beltramo E , Pagnozzi F , et al.   Thiamine corrects delayed replication and decreases production of lactate and advanced glycation end-products in bovine retinal and human umbilical vein endothelial cells cultured under high glucose conditions . Diabetologia . 1996;39:1263–1268
  8. Stracke H , Hammes H , Werkmann D , et al.   Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats . Exp Clin Endocrinol Diabetes . 2001;109:330–336
  9. Pomero F , Molinar Min A , La Selva M , et al.   Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose . Acta Diabetologica . 2001;38:135–138
  10. Witko-Sarsat V , Friedlander M , Capeillere-Blandin C , et al.   Advanced oxidation protein products as a novel marker of oxidative stress in uremia . Kidney Int . 1996;49:1304–1313
  11. Suliman ME , Heimburger O , Barany P , et al.   Plasma pentosidine is associated with inflammation and malnutrition in end-stage renal disease patients starting on dialysis therapy . J Am Soc Nephrol . 2003;14:1614–1622
  12. Toyokuni S , Tanaka T , Hattori Y , et al.   Quantitative immunohistochemical determination of 8-hydroxy-2’-deoxyguanosine by a monoclonal antibody N45.1 (Its application to ferric nitrilotriacetate-induced renal carcinogenesis model) . Lab Invest . 1997;76:365–374
  13. Ivanovski O , Szumilak D , Nguyen-Khoa T , et al.   The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice . Kidney Int . 2005;67:2288–2294
  14. Boaz M , Smetana S , Weinstein T , et al.   Secondary prevention with antioxidants of cardiovascular disease in end-stage renal disease (SPACE) (Randomised placebo-controlled trial) . Lancet . 2000;360:23–33
  15. Tepel M , van der Giet M , Statz M , et al.   The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure . Circulation . 2003;107:992–995
  16. Gibson GE , Zhang H . Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration . Neurochem Int . 2002;40:493–504
  17. Descombes E , Hanck AB , Fellay G . Water soluble vitamins in chronic hemodialysis patients and need for supplementation . Kidney Int . 1993;43:1319–1328
  18. Niwa T , Ito T , Matsui E , et al.   Plasma level and transfer capacity of thiamin in patients undergoing long-term hemodialysis . Am J Clin Nutr . 1975;28:1105–1109
  19. Allman MA , Truswell AS , Tiller DI . Vitamin supplementation of patients receiving hemodialysis . Med J Aust . 1989;150:130–133
  20. Stone WJ , Warnock LG , Wagner C . Vitamin B6 deficiency in uremia . Am J Clin Nutr . 1975;28:950–957
  21. Kopple JD , Mercurio K , Blumenkrantz MJ , et al.   Daily requirement for pyridoxine supplementation in chronic renal failure . Kidney Int . 1981;19:694–704
  22. Perry TA , Weerasuriya A , Mouton PR , et al.   Pyridoxine-induced toxicity in rats (A stereological quantification of the sensory neuropathy) . Exp Neurol . 2004;190:133–144
  23. Suliman ME , Divino-Filho JC , Barany P , et al.   Effect of high dose folic-acid pyridoxine on plasma erythrocyte sulfur amino acids in hemodialysis patients . J Am Soc Nephrol . 1999;10:1287–1296
  24. Schoonen WG , Wanamarta AH , van den Klein VM , et al.   Respiratory failure and stimulation of glycolysis in Chinese hamster ovary cells exposed to normobaric hyperoxia . J Biol Chem . 1990;265:1118–1124
  25. Degenhardt TP , Alderson NL , Arrington DD , et al.   Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat . Kidney Int . 2002;61:939–950
  26. Fragedaki E , Nebel M , Schupp N , et al.   Genomic damage and circulating AGE levels in patients undergoing daily versus standard haemodialysis . Nephrol Dial Transplant . 2005;20:1936–1943
  27. Himmelfarb J , Stenvinkel P , Ikizler A , et al.   The elephant in uremia (oxidant stress as a unifying concept of cardiovascular disease in uremia) . Kidney Int . 2002;62:1524–1538
  28. Danielski M , Ikisler A , McMonagle E , et al.   Linkage of hypoalbuminemia, inflammation and oxidative stress in patients receiving maintenance hemodialysis therapy . Am J Kidney Dis . 2003;42:286–294
  29. Stenvinkel P , Holmberg I , Heimburger O , et al.   A study of plasmalogen as an index of oxidative stress in patients with chronic renal failure. Evidence of increased oxidative stress in malnourished patients . Nephrol Dial Transplant . 1998;13:2594–2600
  30. Babaei-Jadidi R , Karachalias N , Ahmed N , et al.   Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine . Diabetes . 2003;52:2110–2120
  31. Ramirez G , Chen M , Boyce HW , et al.   The plasma and red cell vitamin B levels of chronic hemodialysis patients (A longitudinal study) . Nephron . 1986;42:41–46

 Supported by Karolinska Institutet, Stockholm, Sweden, and by a grant from Baxter Healthcare Corporation, Deerfield, Illinois.

PII: S1051-2276(06)00003-3

doi: 10.1053/j.jrn.2006.01.002

Journal of Renal Nutrition
Volume 16, Issue 2 , Pages 119-124 , April 2006

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