Journal of Renal Nutrition
Volume 16, Issue 3 , Pages 245-247 , July 2006

L-Arginine: A New Opportunity in the Management of Clinical Derangements in Dialysis Patients

  • Guido Bellinghieri (Prof)

      Affiliations

    • Division of Nephrology and Dialysis, University of Messina, Messina, Italy.
    • Corresponding Author InformationAddress reprint requests to Guido Bellinghieri, Division of Nephrology and Dialysis, Facolta di Medicina e Chirugia di Messina, University of Messina, Messina, Italy 98125.
    • ,
  • Domenico Santoro, MD

      Affiliations

    • Division of Nephrology and Dialysis, University of Messina, Messina, Italy.
    • ,
  • Agostino Mallamace, MD

      Affiliations

    • Division of Nephrology and Dialysis, University of Messina, Messina, Italy.
    • ,
  • Vincenzo Savica (Associate Prof)

      Affiliations

    • Division of Nephrology and Dialysis, Papardo Hospital, University of Messina, Messina, Italy.

References 

  1. Reyes AA , Karl IE , Klahr S . Role of arginine in health and in renal disease . Am J Physiol . 1994;267:F331–F346
  2. Raghavan SA , Dikshit M . Vascular regulation by the L-arginine metabolites, nitric oxide and agmatine . Pharmacol Res . 2004;49:397–414
  3. Boger RH . Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the “L-arginine paradox” and acts as a novel cardiovascular risk factor . J Nutr . 2004;134:2842S–2847S
  4. Lau T , Owen W , Yu YM , et al.   Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients . J Clin Invest . 2000;105:1217–1225
  5. Reyes AA , Karl IE , Kissane J , et al.   L-arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats . J Am Soc Nephrol . 1993;4:1039–1045
  6. Sabbatini M , Pisani A , Uccello F , et al.   Arginase inhibition slows the progression of renal failure in rats with renal ablation . Am J Physiol Renal Physiol . 2003;284:F680–F687
  7. Palloshi A , Fragasso G , Piatti P , et al.   Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries . Am J Cardiol . 2004;93:933–935
  8. DeNicola L , Bellizzi V , Minutolo R , et al.   Randomized, double-blind, placebo-controlled study of arginine supplementation in chronic renal failure . Kidney Int . 1999;56:674–684
  9. Gokce N . L-arginine and hypertension . J Nutr . 2004;134:2807S–2811S discussion 2818S-2819S
  10. Lim DS , Mooradian SJ , Goldberg CS , et al.   Effect of oral L-arginine on oxidant stress, endothelial dysfunction, and systemic arterial pressure in young cardiac transplant recipients . Am J Cardiol . 2004;94:828–831

PII: S1051-2276(06)00084-7

doi: 10.1053/j.jrn.2006.04.004

Journal of Renal Nutrition
Volume 16, Issue 3 , Pages 245-247 , July 2006

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