« Previous
Next »
Journal of Renal Nutrition
Volume 16, Issue 3
, Pages 253-258
, July 2006
Cinacalcet HCl: A Novel Treatment for Secondary Hyperparathyroidism Caused by Chronic Kidney Disease
References
- Magnitude and impact of abnormal mineral metabolism in hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS) . Am J Kidney Dis . 2004;44:34–38
- Association of elevated serum PO4, Ca PO4 product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients . J Am Soc Nephrol . 2001;12:2131–2138
- Short and long-term efficacy of total parathyroidectomy with immediate autografting compared with subtotal parathyroidectomy in hemodialysis patients . J Am Soc Nephrol . 1992;3:1008–1017
- Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid . Nature . 1993;366:575–580
- Calcimimetics with potent and selective activity on the parathyroid calcium receptor . Proc Natl Acad Sci U S A . 1998;95:4040–4045
- The control of phosphate excretion in uremia . J Clin Invest . 1966;45:672–677
- Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency . Am J Kidney Dis . 2004;44:250–256
- The renal PTH/PTHrP receptor is down-regulated in rats with chronic renal failure . Kidney Int . 1994;45:605–611
- . Mechanisms of secondary hyperparathyroidism . Am J Physiol Renal Physiol . 2002;283:F367–F376
- Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients . J Clin Invest . 1993;92:1436–1443
- Histopathology, pathophysiology, and indications for surgical treatment of renal hyperparathyroidism . Semin Surg Oncol . 1997;13:78–86
- Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism . Kidney Int . 1997;51:328–336
- Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism . J Clin Endocrinol Metab . 1996;81:1598–1606
- Clonal analysis of nodular parathyroid hyperplasia in renal hyperparathyroidism . World J Surg . 1996;20:744–750
-
Histopathology and pathophysiology of secondary hyperparathyroidism due to chronic renal failure
.
Clin Nephrol
. 1995;44(suppl 1):S42–S47
- Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia . J Clin Invest . 1995;95:2047–2054
- . Mechanisms through which parathyroid hormone mediates its deleterious effects on organ function in uremia . Semin Nephrol . 1994;14:219–231
- . Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure . Kidney Int . 1999;56:383–392
- . Cardiac disease in chronic uremia (Pathophysiology) . Adv Ren Replace Ther . 1997;4:212–224
- Blood-pressure-independent wall thickening of intramyocardial arterioles in experimental uraemia (Evidence for a permissive action of PTH) . Nephrol Dial Transplant . 1995;10:2043–2048
- Impaired flow-mediated vasodilation of the brachial artery in patients with primary hyperparathyroidism improves after parathyroidectomy . Cardiovasc Res . 2000;47:813–818
- Arterial media calcification in end-stage renal disease (Impact on all-cause and cardiovascular mortality) . Nephrol Dial Transplant . 2003;18:1731–1740
- . The calcium-sensing receptor (A key factor in the pathogenesis of secondary hyperparathyroidism) . Am J Physiol Renal Physiol . 2005;288:F253–F264
- Direct in vivo comparison of calcium regulated parathyroid hormone secretion in normal volunteers and patients with secondary hyperparathyroidism . J Clin Endocrinol Metab . 1993;76:1489–1494
- N(2)-benzyl-N(1)-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues (Development of calindol as a new calcimimetic acting at the calcium sensing receptor) . Bioorg Med Chem Lett . 2004;14:3345–3349
- Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain . J Biol Chem . 2004;279:18990–18997
- . A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure. Rapid communication . Kidney Int . 1998;53:223–227
- A calcimimetic agent lowers plasma parathyroid hormone levels in patients with secondary hyperparathyroidism . Kidney Int . 2000;58:436–445
-
Mimpara (Cinacalcet) SPC
. Breda, the Netherlands: Amgen; 2004;
-
Sensipar (Cinacalcet HCl) Prescribing Information
. Breda, the Netherlands: Amgen; 2004;
-
Single doses of the calcimimetic AMG-073 reduce parathyroid hormone levels in a dose dependent manner in hemodialysis patients with secondary hyperparathyroidism
.
J Am Soc Nephrol
. 2000;11:573A
- Short-term effects of parathyroidectomy on plasma biochemistry in chronic uremia (A prospective study) . Kidney Int . 1989;36:120–126
-
.
Down-regulation of Ca2+ transporters in kidney and duodenum by the calcimimetic compound NPS R-467
.
J Am Soc Nephrol
. 2003;14:
SA-P073, (abstr)
-
Short-term treatment of secondary hyperparathyroidism (SHTP) with the calcimimetic agent AMG 073
.
J Am Soc Nephrol
. 2001;12:764A
- Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis . N Engl J Med . 2004;350:1516–1525
-
Sustained control of uraemic secondary hyperparathyroidism (SHPT) after three years of treatment with the calcimimetic cinacalcet HCL
(A single centre experience)
. 2003;
Poster presented at the 40th ERA-EDTA World Congress of Nephrology, Berlin
- The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease . J Am Soc Nephrol . 2003;14:575–583
- The calcimimetic AMG 073 reduces parathyroid hormone and calcium × phosphorus in secondary hyperparathyroidism . Kidney Int . 2003;63:248–254
-
Cinacalcet HCl (Sensipar) for the management of secondary hyperparathyroidism in study patients receiving peritoneal dialysis
.
J Am Soc Nephrol
. 2004;15:280A;
(abstr)
-
.
Cinacalcet HCl in secondary hyperparathyroidism
.
Official Evening Symposium
(ASN 2004)
. St. Louis, Missouri: American Society of Nephrology; 2004;
October 27 to November 1
- Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl . Kidney Int . 2005;67:760–771
- Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl . Nephrol Dial Transplant . 2005;20:2186–2193
- . Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism . Kidney Int . 2005;68:1793–1800
- Natural history of parathyroid function and calcium metabolism after kidney transplantation (A single-centre study) . Nephrol Dial Transplant . 2004;19:1281–1287
- The calcimimetic cinacalcet normalizes serum calcium in renal transplant patients with persistent hyperparathyroidism . Nephrol Dial Transplant . 2005;20:1311–1314
- Successful treatment of hypercalcemia with cinacalcet in renal transplant recipients with persistent hyperparathyroidism . Nephrol Dial Transplant . 2005;20:1315–1319
- Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent . J Clin Endocrinol Metab . 1998;83:1080–1082
-
Clinical course of 10 patients with inoperable parathyroid carcinoma treated with the calcimimetic cinacalcet HCl
.
J Bone Miner Res
. 2004;19:S103;
(abstr F497)
PII: S1051-2276(06)00091-4
doi: 10.1053/j.jrn.2006.04.010
© 2006 National Kidney Foundation, Inc. Published by Elsevier Inc All rights reserved.
« Previous
Next »
Journal of Renal Nutrition
Volume 16, Issue 3
, Pages 253-258
, July 2006

