Journal of Renal Nutrition
Volume 17, Issue 3 , Pages 196-204 , May 2007

Body Composition and Physical Activity in End-Stage Renal Disease

  • Karen M. Majchrzak, MS

      Affiliations

    • Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee.
  • ,
  • Lara B. Pupim, MD

      Affiliations

    • Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee.
    • General Medicine Therapeutic Area, Nephrology, Amgen Inc., Thousand Oaks, California.
  • ,
  • Mary Sundell, RD

      Affiliations

    • Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee.
  • ,
  • T. Alp Ikizler, MD

      Affiliations

    • Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee.
    • Corresponding Author InformationAddress reprint requests to T. Alp Ikizler, MD, Vanderbilt University Medical Center, 1161 21st Ave. South and Garland, Division of Nephrology, S-3223 MCN, Nashville, TN 37232-2372.

References 

  1. Goldwasser P, Mittman M, Antignani A, et al. Predictors of mortality on hemodialysis. J Am Soc Nephrol. 1993;3:1613–1622
  2. Lowrie EG, Huang WH, Lew NL, et al. The relative contribution of measured variables to death risk among hemodialysis patients. In:  Friedman EA editors. Death on hemodialysis. Amsterdam: Kluwer Academic Publishers; 1994;p. 121–141
  3. Lowrie EG, Lew NL. Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis. 1990;15:458–482
  4. Owen WF, Lew NL, Liu Y, et al. The urea reduction ratio and serum albumin concentrations as predictors of mortality in patients undergoing hemodialysis. N Engl J Med. 1993;329:1001–1006
  5. Kato A, Odamaki M, Yamamoto T, et al. Influence of body composition on 5 year mortality in patients on regular haemodialysis. Nephrol Dial Transplant. 2003;18:333–340
  6. Johansen KL, Shubert T, Doyle J, et al. Muscle atrophy in patients receiving hemodialysis: effects on muscle strength, muscle quality, and physical function. Kidney Int. 2003;63:291–297
  7. Churchill DN, Torrance GW, Taylor DW, et al. Measurement of quality of life in end-stage renal disease: the time trade-off approach. Clin Invest Med. 1987;10:14–20
  8. Bohannon RW. Sit-to-stand test for measuring performance of lower extremity muscles. Percept Mot Skills. 1995;80:163–166
  9. Guyatt GH, Sullivan MJ, Thompson PJ, et al. The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J. 1985;132:919–923
  10. Kramer WJ, Fry AC. Strength testing: development and evaluation of methodology. In:  Maud P,  Foster C editor. Physiological assessment of human fitness. Champaign, IL: Human Kinetics; 1995;p. 115–138
  11. Ikizler TA, Pupim LB, Brouillette JR, et al. Hemodialysis stimulates muscle and whole-body protein loss and alters substrate oxidation. Am J Physiol Endocrinol Metab. 2002;282:E107–E116
  12. Lim VS, Bier DM, Flanigan MJ, et al. The effect of hemodialysis on protein metabolism: a leucine kinetic study. J Clin Invest. 1993;91:2429–2436
  13. Pupim LB, Flakoll PJ, Brouillette JR, et al. Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J Clin Invest. 2002;110:483–492
  14. Pupim LB, Heimburger O, Qureshi AR, et al. Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int. 2005;68:2368–2374
  15. Kaizu Y, Ohkawa S, Odamaki M, et al. Association between inflammatory mediators and muscle mass in long-term hemodialysis patients. Am J Kidney Dis. 2003;42:295–302
  16. Kaysen GA. Interpretation of plasma protein measurements in end-stage renal disease. Blood Purif. 2000;18:337–342
  17. Kaysen GA. C-reactive protein: a story half told. Semin Dial. 2000;13:143–146
  18. Johansen KL, Kaysen GA, Young BS, et al. Longitudinal study of nutritional status, body composition, and physical function in hemodialysis patients. Am J Clin Nutr. 2003;77:842–846
  19. Axelsson J, Qureshi AR, Suliman ME, et al. Truncal fat mass as a contributor to inflammation in end-stage renal disease. Am J Clin Nutr. 2004;80:1222–1229
  20. Aparicio M, Cano N, Chauveau P, et al. French Study Group for Nutrition in Dialysis Nutritional status of haemodialysis patients: a French national cooperative study. Nephrol Dial Transplant. 1999;14:1679–1686
  21. Jones CH, Newstead CG, Wills EJ, et al. Serum albumin and survival in CAPD patients: the implications of concentration trends over time. Nephrol Dial Transplant. 1997;12:554–558
  22. Kalantar-Zadeh K, Abbott KC, Salahudeen AK, et al. Survival advantages of obesity in dialysis patients. Am J Clin Nutr. 2005;81:543–554
  23. Friedman AN. Adiposity in dialysis: good or bad?. Semin Dial. 2006;19:136–140
  24. Beddhu S, Pappas LM, Ramkumar N, et al. Effects of body size and body composition on survival in hemodialysis patients. J Am Soc Nephrol. 2003;14:2366–2372
  25. Johansen KL, Young B, Kaysen GA, et al. Association of body size with outcomes among patients beginning dialysis. Am J Clin Nutr. 2004;80:324–332
  26. DeOreo PB. Hemodialysis patient-assessed functional health status predicts continued survival, hospitalization, and dialysis-attendance compliance. Am J Kidney Dis. 1997;30:204–212
  27. Takahashi N, Yuasa S, Fukunaga M, et al. Long-term evaluation of nutritional status using dual-energy x-ray absorptiometry in chronic hemodialysis patients. Clin Nephrol. 2003;59:373–378
  28. Johansen KL, Painter PL, Sakkas GK, et al. Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: a randomized, controlled trial. J Am Soc Nephrol. 2006;17:2307–2314
  29. de Castro JM. What are the major correlates of macronutrient selection in Western populations?. Proc Nutr Soc. 1999;58:755–763
  30. Miller WC, Lindeman AK, Wallace J, et al. Diet composition, energy intake, and exercise in relation to body fat in men and women. Am J Clin Nutr. 1990;52:426–430
  31. Rocco MV, Paranandi L, Burrowes JD, et al. Nutritional status in the HEMO Study cohort at baseline (Hemodialysis). Am J Kidney Dis. 2002;39:245–256
  32. Ge YQ, Wu ZL, Xu YZ, et al. Study on nutritional status of maintenance hemodialysis patients. Clin Nephrol. 1998;50:309–314
  33. Sharma M, Rao M, Jacob S, et al. A dietary survey in Indian hemodialysis patients. J Ren Nutr. 1999;9:21–25
  34. K/DOQI, National Kidney Foundation. Clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis. 2000;35:S1–S140
  35. Beddhu S, Ramkumar N, Pappas LM. Normalization of protein intake by body weight and the associations of protein intake with nutritional status and survival. J Ren Nutr. 2005;15:387–397
  36. Johansen KL, Chertow GM, Ng AV, et al. Physical activity levels in patients on hemodialysis and healthy sedentary controls. Kidney Int. 2000;57:2564–2570
  37. Zamojska S, Szklarek M, Niewodniczy M, et al. Correlates of habitual physical activity in chronic haemodialysis patients. Nephrol Dial Transplant. 2006;21:1323–1327
  38. Trost SG, McIver KL, Pate RR. Conducting accelerometer-based activity assessments in field-based research. Med Sci Sports Exerc. 2005;37:S531–S543

 This work is supported in part by National Institutes of Health Grants R01 DK-45604, K24 DK-062849 and Diabetes Research and Training Center Grant DK-20593 from the National Institute of Diabetes, Digestive and Kidney Diseases, and General Clinical Research Center Grant No. M01 RR-00095 from the National Center for Research Resources and Satellite Health Extramural Grant Program. L. B. Pupim is currently an employee of Amgen, Inc. (since August of 2005) and declares no conflict of interest with the work presented.

PII: S1051-2276(07)00002-7

doi: 10.1053/j.jrn.2007.01.003

Journal of Renal Nutrition
Volume 17, Issue 3 , Pages 196-204 , May 2007