Journal of Renal Nutrition
Volume 17, Issue 4 , Pages 275-281 , July 2007

Carnitine Content in Different Muscles of Patients Receiving Maintenance Hemodialysis

  • Alicja Dębska-Ślizień, MD, PhD

      Affiliations

    • Departments of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland.
    • Corresponding Author InformationAddress reprint requests to Alicja Dębska-Ślizień, MD, PhD, Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdańsk, Dębinki Street 7, Gdańsk 80-211, Poland.
    • ,
  • Aleksandra Kawecka, MD, PhD

      Affiliations

    • Department of General Surgery and Transplantation, Medical University of Gdańsk, Gdańsk, Poland.
    • ,
  • Klaudiusz Wojnarowski, MD

      Affiliations

    • Departments of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland.
    • ,
  • Dariusz Zadroṅy, MD, PhD

      Affiliations

    • Department of General Surgery and Transplantation, Medical University of Gdańsk, Gdańsk, Poland.
    • ,
  • Danuta Kunicka, MA

      Affiliations

    • Department of Clinical Nutrition, Medical University of Gdańsk, Gdańsk, Poland.
    • ,
  • Ewa Król, MD, PhD

      Affiliations

    • Departments of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland.
    • ,
  • Wiesława Łysiak-Szydłowska, MD, PhD

      Affiliations

    • Department of Clinical Nutrition, Medical University of Gdańsk, Gdańsk, Poland.
    • ,
  • Bolesław Rutkowski, MD, PhD

      Affiliations

    • Departments of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland.

References 

  1. Hoppel C. The physiological role of carnitine. In:  Ferrari R,  DiMauro S,  Sherwood G editor. L-carnitine and its role in medicine: from function to therapy. London: Academic Press; 1992;p. 5–17(editorial)
  2. Wanner C, Hörl WH. Carnitine abnormalities in patients with renal insufficiency (Pathophysiological and therapeutical aspects). Nephron. 1988;50:89–102(editorial)
  3. Ahmad S. Carnitine, kidney and renal dialysis. In:  Ferrari R,  DiMauro S,  Sherwood G editor. L-carnitine and its role in medicine: from function to therapy. London: Academic Press; 1992;p. 381–400
  4. Golper TA, Wolfson M, Ahmad S, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. I. Carnitine concentrations and lipid effects. Kidney Int. 1990;38:904–911
  5. Dębska-Ślizień A, Kawecka A, Wojnarowski K, et al. Correlation between plasma carnitine, muscle carnitine and glycogen in maintenance hemodialysis patients. Int J Artif Organs. 2000;23(2):90–96
  6. Mingardi G, Bizzi A, Cini M, et al. Carnitine balance in hemodialysis patients. Clin Nephrol. 1980;13:269–270
  7. Cederblad G, Harper P, Lingren K. Spectrophotometry of carnitine in biological fluids and tissue with Cobas Bio centrifugal analyser. Clin Chem. 1986;32:342–346
  8. Sałek J, Mierzewski P, Wąsewicz M, et al. Carnitine in serum and urine (Monitoring of L-carnitine therapy). Diagn Lab. 1989;1(25):109–118
  9. Maszota M, Zdrójkowska-Król E, Sabiniewicz R, et al. Determination of L-carnitine and its esters level in tissue samples. Diagn Lab. 1992;24(2):9–13
  10. Wanner C, Förstner-Wanner S, Schaeffer G, et al. Serum-free carnitine, carnitine esters and lipids in patients on peritoneal and hemodialysis. Am J Nephrol. 1986;6:206–211
  11. Moorthy AV, Rosenblum M, Rajaram R, et al. A comparison of plasma and muscle carnitine levels in patients on peritoneal or hemodialysis for chronic renal failure. Am J Nephrol. 1983;3:205–208
  12. Fagher B, Thysell H, Nilsson-Ehle P, et al. The effect of D,L-carnitine supplementation on muscle metabolism, neuropathy, cardiac and hepatic function in hemodialysis patients. Acta Med Scand. 1982;212:115–120
  13. Sakurauchi Y, Matsumoto Y, Shinzato T, et al: Effect of L-carnitine supplementation on muscular symptoms in hemodialyzed patients. Am J Kidney Dis 32:258-264, 199
  14. Guarnieri G, Toigo G, Crapesi L, et al. Carnitine metabolism in chronic renal failure. Kidney Int. 1987;32(Suppl 22):116–127
  15. Ricanati ES, Tserng KY, Hoppel CL. Abnormal fatty acid utilization during prolonged fasting in chronic uremia. Kidney Int. 1987;32(Suppl 22):145–148
  16. Vacha GM, Corsi M, Giorcelli G, et al. Serum and muscle L-carnitine levels in hemodialyzed patients, during and after long-term L-carnitine treatment. Curr Ther Res. 1985;37:505–516
  17. Battistella PA, Angelini C, Vergani L, et al. Carnitine deficiency induced during haemodialysis (letter). Lancet. 1978;1:939
  18. Bazzi C, Di Donato , Castiglione A, et al. Carnitine metabolism in short- and long-term maintenance hemodialysis. In:  Borum PR editors. Clinical aspects of human carnitine deficiency. New York: Pergamon Press; 1986;p. 245
  19. Hiatt WR, Koziol BJ, Shapiro JI, Brass EP. Carnitine metabolism during exercise in patients on chronic hemodialysis. Kidney Int. 1992;41:1613–1619
  20. Hiatt WR, Rogensteiner JG, Wolfel EE, et al. Carnitine and acylcarnitine metabolism during exercise in humans (Dependence on skeletal muscle metabolic state). J Clin Invest. 1989;E4:1167–1173
  21. Harper P, Wadström C, Cederblad G. Carnitine measurements in liver, muscle tissue and blood in normal subject. Clin Chem. 1993;39(4):592–599
  22. Mitchell ME. Carnitine metabolism in human subject II (Values of carnitine in biological fluids and tissues of “normal” subject). Am J Clin Nutr. 1978;31(2):293–306

PII: S1051-2276(07)00111-2

doi: 10.1053/j.jrn.2007.05.002

Journal of Renal Nutrition
Volume 17, Issue 4 , Pages 275-281 , July 2007

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