Journal of Renal Nutrition
Volume 17, Issue 5 , Pages 343-349 , September 2007

Serum Levels of Folate and Cobalamin Are Lower in Depressed Than in Nondepressed Hemodialysis Subjects

  • Louise Clement, MS, RD, LD, CSR

      Affiliations

    • South Plains Kidney Disease Center, Lubbock, Texas.
    • Corresponding Author InformationAddress reprint requests to Louise Clement, MS, RD, LD, CSR, South Plains Kidney Disease Center, 1607 W. Loop 289, Lubbock, TX 79416.
    • ,
  • Mallory Boylan, PhD, RD, LD

      Affiliations

    • Department of Nutrition, Hospitality, and Retailing, Texas Tech University, Lubbock, Texas.
    • ,
  • Virginia G. Miller, PhD, RN, CS, FNP

      Affiliations

    • School of Nursing, Texas Tech University Health Sciences Center, Lubbock, Texas.
    • ,
  • Mary Rockwell, RD, LD, CSR

      Affiliations

    • Dialysis Center of Lubbock, Lubbock, Texas.
    • ,
  • Kendra Allred, MS, RD, LD

      Affiliations

    • Department of Nutrition, Hospitality, and Retailing, Texas Tech University, Lubbock, Texas.

References 

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  4. Wilson B, Spittal J, Heidenheim P, et al. Screening for depression in chronic hemodialysis patients: comparison of the Beck Depression Inventory, primary nurse, and nephrology team. Hemodial Int. 2006;10:35–41
  5. Bottiglieri T, Laundy M, Crellin R, et al. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Pschiatry. 2000;69:228–232
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  9. Morris MS, Fava M, Jacques PF, et al. Depression and folate status in the US population. Psychother Psychosom. 2003;7:80–87
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  12. Ubbink JB, Vermaak WJ, van der Merwe A, et al. Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr. 1993;57:47–53
  13. Selhub J, Bagley LC, Miller J, et al. B vitamins, homocysteine, and neurocognitive functioning. Am J Clin Nutr. 2000;71(Suppl):614S–620S
  14. Loehrer F, Angst C, Brunner F, et al. Evidence for disturbed S-adenosylmethionine:S-adenosylhomocysteine ratio in patients with end-stage renal failure: a cause for disturbed methylation reactions. Nephrol Dial Transplant. 1998;13:656–661
  15. Bostom AG, Shemin D, Lapane KL, et al. High dose B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Kidney Int. 1996;49:147–152
  16. Righetti M, Serbelloni P, Milani S, et al. Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients. Blood Purif. 2006;24:379–386
  17. Walrath LL, Johnstone S. In: Handbook for utilization of SF-36 quality of life survey with dialysis patients (Fresenius Medical Care-North America). 2003;p. 11
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  19. Mollaoglu M. Depression and health-related quality of life in hemodialysis patients. Dial Transplant. 2004;33:544–555
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  21. Lindenbaum J, Healton EB, Savage DG, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anaemia or macrocytosis. N Engl J Med. 1988;318:1720–1728
  22. Papakostas GI, Petersen T, Lebowitz BD, et al. The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol. 2005;8:523–528
  23. Lewis S, Lawlor D, Davey Smith G, et al. The thermolabile variant of MTHFR is associated with depression in the British Women’s Heart and Health Study and a meta-analysis. Mol Psychiatry. 2006;11:352–360

 This research was supported by a grant from the National Kidney Foundation Council on Renal Nutrition.

PII: S1051-2276(07)00116-1

doi: 10.1053/j.jrn.2007.05.007

Journal of Renal Nutrition
Volume 17, Issue 5 , Pages 343-349 , September 2007

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