Inadequate Energy and Excess Protein Intakes May Be Associated With Worsening Renal Function in Chronic Kidney Disease

Huang, Meng-Chuan; Chen, Mei-En; Hung, Hsin-Chia; Chen, Hung-Chun; Chang, Wen-Tsan; Lee, Chien-Hung; Wu, Yueh-Ying; Chiang, Hung-Che; Hwang, Shang-Jyh

doi:10.1053/j.jrn.2007.08.003

« Previous Next »Journal of Renal Nutrition
Volume 18, Issue 2 , Pages 187-194, March 2008

Inadequate Energy and Excess Protein Intakes May Be Associated With Worsening Renal Function in Chronic Kidney Disease

Meng-Chuan Huang, RD, PhD
- Department of Nutrition, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
- Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Mei-En Chen, MS, RD
- Department of Nutrition, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Hsin-Chia Hung, PhD
- Graduate Institute of Health Care and Department of Food and Nutrition, Mei-Ho Technology Institute, Pint-Tung, Taiwan
Hung-Chun Chen, MD, PhD
- Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital and Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Wen-Tsan Chang, MD
- Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan ^¶Graduate Institute of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
Chien-Hung Lee, PhD
- Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan ^¶Graduate Institute of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
Yueh-Ying Wu, MS, RD
- Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan ^¶Graduate Institute of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
Hung-Che Chiang, MD, PhD
- Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Shang-Jyh Hwang, MD
- Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital and Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
- Address reprint requests to Shang-Jyh Hwang, MD, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tzyou First Road, Kaohsiung 807, Taiwan.

Objectives

Dietary energy and protein play important roles in chronic kidney disease (CKD). This study investigates the relationship between energy/protein intake status and renal function in CKD.

Design and Study Population

This cross-sectional study included 599 adult patients diagnosed with stage 3 to 5 CKD in nephrology and nutrition outpatient clinics in Taiwan.

Main Outcome Measure

Energy and protein intakes were assessed using 24-h dietary recall. We recorded recommended calorie/protein amounts and renal function indices, glomerular filtration rate (GFR), creatinine, and blood urea nitrogen (BUN). Patients were categorized into three intake calorie/protein groups by a ratio of actual intake vs. recommended intake. High intake was defined as a ratio of actual intake/recommended intake ≧110%, moderate intake as ≧90% to <110%, and low intake as <90%. Data were analyzed by paired t test, one-way analysis of variance, least significant differences, and multiple linear regression.

Results

The energy and protein intakes in CKD patients were significantly higher and lower than recommended levels (P < .001). Low energy intake was significantly related to worsening GFR at increments of −4.41 mL/min/1.73 m², compared with moderate and high energy intake (P = .008); high protein intake was also associated with worsening GFR at increments of −3.50 mL/min/1.73m², compared with moderate and low protein intake (P < .001). Low energy intake and high protein intake were significantly positively correlated with elevations in creatinine and BUN.