Journal of Renal Nutrition
Volume 18, Issue 5 , Pages 448-455 , September 2008

Feedback Inhibition of Cholesterol Biosynthesis by Dietary Cholesterol in Experimental Chronic Renal Failure

  • Michal Chmielewski, MD, PhD

      Affiliations

    • Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    • Corresponding Author InformationAddress reprint requests to Michal Chmielewski, MD, PhD, Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Ul. Debinki 7, 80-211 Gdansk, Poland.
    • ,
  • Elzbieta Sucajtys-Szulc, MSc

      Affiliations

    • Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    • ,
  • Ewa Kossowska, PhD

      Affiliations

    • Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
    • ,
  • Julian Swierczynski, MD, PhD

      Affiliations

    • Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
    • ,
  • Boleslaw Rutkowski, MD, PhD

      Affiliations

    • Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    • ,
  • Wojciech Boguslawski, MD, PhD

      Affiliations

    • Department of Social and Clinical Gerontology, Medical University of Gdansk, Gdansk, Poland

References 

  1. Stenvinkel P. Interactions between inflammation, oxidative stress, and endothelial dysfunction in end-stage renal disease. J Ren Nutr. 2003;13:144–148
  2. Vaziri ND. Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences. Am J Physiol Renal Physiol. 2006;290:F262–F272
  3. Chmielewski M, Nieweglowski T, Swierczynski J, et al. Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure. Mol Cell Biochem. 2001;228:33–37
  4. Chmielewski M, Sucajtys E, Swierczynski J, et al. Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure. Mol Cell Biochem. 2003;246:187–191
  5. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002;109:1125–1131
  6. Chmielewski M, Sucajtys-Szulc E, Kossowska E, et al. Increased gene expression of liver SREBP-2 in experimental chronic renal failure. Atherosclerosis. 2007;191:326–332
  7. Gould RG. Lipid metabolism and atherosclerosis. Am J Med. 1951;11:209–227
  8. Swierczynski J, Korczynska J, Szolkiewicz M, et al. Low leptin mRNA level in adipose tissue and normoleptinemia in experimental chronic renal failure. Exp Nephrol. 2001;9:54–59
  9. Liang K, Vaziri ND. Upregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure. Am J Physiol Endocrinol Metab. 2002;283:E676–E681
  10. Podjarny E, Bernheim J, Hasdan G, et al. Additive renoprotective effect of candesartan and tetrahydrobiopterin in rats after 5/6 nephrectomy. Nephrol Dial Transplant. 2007;22:1864–1872
  11. Sperry W, Webb M. A revision of the Schoenheimer-Sperry method for cholesterol determination. J Biol Chem. 1950;187:97–106
  12. Shapiro DJ, Nordstrom JL, Mitschelen JJ, et al. Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim Biophys Acta. 1974;370:369–377
  13. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156–159
  14. Freeman WM, Walker SJ, Vrana KE. Quantitative RT-PCR: pitfalls and potential. Biotechniques. 1999;26:112–122
  15. Marone M, Mozzetti S, De Ritis D, et al. Semiquantitative RT-PCR analysis to assess the expression levels of multiple transcripts from the same sample. Biol Proced Online. 2001;3:19–25
  16. Ide T, Ashakumary L, Takahashi Y, et al. Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. Biochim Biophys Acta. 2001;1534:1–13
  17. Pandak WM, Vlahcevic ZR, Heuman DM, et al. Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in rats with subtotal nephrectomy. Kidney Int. 1994;46:358–364
  18. Kopito RR, Weinstock SB, Freed LE, et al. Metabolism of plasma mevalonate in rats and humans. J Lipid Res. 1982;23:577–583
  19. Kim C, Vaziri ND. Down-regulation of hepatic LDL receptor-related protein (LRP) in chronic renal failure. Kidney Int. 2005;67:1028–1032
  20. Weintraub M, Burstein A, Rassin T, et al. Severe defect in clearing postprandial chylomicron remnants in dialysis patients. Kidney Int. 1992;42:1247–1252
  21. Jurevics H, Hostettler J, Barrett C, et al. Diurnal and dietary-induced changes in cholesterol synthesis correlate with levels of mRNA for HMG-CoA reductase. J Lipid Res. 2000;41:1048–1054
  22. Cella LK, Van Cauter E, Schoeller DA. Effect of meal timing on diurnal rhythm of human cholesterol synthesis. Am J Physiol. 1995;269:E878–E883
  23. Horton JD, Shimomura I, Brown MS, et al. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest. 1998;101:2331–2339
  24. Vaziri ND, Liang K. ACAT inhibition reverses LCAT deficiency and improves plasma HDL in chronic renal failure. Am J Physiol Renal Physiol. 2004;287:F1038–F1043

 Supported by grants ST 4, ST 41, and W 65 from the Medical University of Gdansk.

PII: S1051-2276(08)00285-9

doi: 10.1053/j.jrn.2008.04.005

Journal of Renal Nutrition
Volume 18, Issue 5 , Pages 448-455 , September 2008

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