Journal of Renal Nutrition
Volume 18, Issue 4 , Pages 375-382 , July 2008

Prevalence of Vitamin D [25(OH)D] Deficiency and Effects of Supplementation With Ergocalciferol (Vitamin D2) in Stage 5 Chronic Kidney Disease Patients

  • Debra Blair, MPH, RD, CSR

      Affiliations

    • Fresenius Medical Care, Western Massachusetts Kidney Center, Springfield, Massachusetts
    • Corresponding Author InformationAddress reprint requests to Debra Blair, MPH, RD, CSR, Fresenius Medical Care, Western Massachusetts Kidney Center, 2000 Main St., Springfield, MA 01103.
  • ,
  • Laura Byham-Gray, PhD, RD

      Affiliations

    • Department of Nutritional Sciences, School of Health Related Professions, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey
  • ,
  • Emily Lewis, MS, RD

      Affiliations

    • Fresenius Medical Care, Chicopee Dialysis, Chicopee, Massachusetts
  • ,
  • Susan McCaffrey, MS, RD

      Affiliations

    • Fresenius Medical Care, Ludlow Dialysis, Ludlow, Massachusetts

References 

  1. Zadshir A, Tareen N, Pan D, et al. The prevalence of hypovitaminosis D among US adults: data from the NHANES III. Ethnicity Dis. 2005;14(Suppl 5):97–101
  2. Hanley DA, Davison KS. Vitamin D insufficiency in North America. J Nutr. 2005;135:332–337
  3. Holik MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81:353–373
  4. MacFarlane GD, Sackrison JL, Ersfeld DL, et al. Evaluation of 25(OH)D in chronic renal failure and end stage renal disease subjects. J Steroid Biochem Mol Biol. 2004;89-90:619–620
  5. Chonchol M, Scragg R. 25-hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey. Kidney Int. 2007;71:134–139
  6. LaClair RE, Hellman RN, Karp SL, et al. Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States. Am J Kidney Dis. 2005;45:1026–1033
  7. Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J. 2001;5:2579–2585
  8. Schleithoff SS, Zitterman A, Tenderich G, et al. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006;83:754–759
  9. Timms PM, Mannan N, Hitman GA, et al. Circulating MMP9, vitamin D and the variations in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders. Q J Med. 2002;95:787–796
  10. Achinger SG, Ayus JC. The role of vitamin D in left ventricular hypertrophy and cardiac function. Kidney Int. 2005;95(Suppl):S37–S42
  11. Whitlatch LW, Young MV, Schwartz GG, et al. 25-hydroxyvitamin D-1α-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transfer. J Steroid Biochem Mol Biol. 2002;81:135–140
  12. Holick MF. Vitamin D for health and in chronic kidney disease. Semin Dial. 2005;18:266–275
  13. Slatopolsky ES, Brown AJ. Vitamin D and renal failure. In:  Feldman D,  Glorieux FH,  Pike JW editor. Vitamin D. San Diego, CA: Academic Press; 1997;p. 849–865
  14. Dusso A, Lopez-Hilker S, Rapp N, et al. Extra-renal production of calcitriol in chronic renal failure. Kidney Int. 1988;34:368–375
  15. Tareen N, Martins D, Zadshir A, et al. The impact of routine vitamin supplementation on serum levels of 25(OH)D3 among the general adult population and patients with chronic kidney disease. Ethnicity Dis. 2005;14(Suppl 5):102–106
  16. Holick MF. Vitamin D deficiency in CKD: why should we care?. Am J Kidney Dis. 2005;45:1119–1121
  17. Jacob AI, Sallman A, Santiz Z, et al. Defective photoproduction of cholecalciferol in normal and uremic humans. J Nutr. 1984;114:1313–1319
  18. Seibert F, Levin NW, Kuhlmann MK. Immunomodulating effects of vitamin D analogs in hemodialysis patients. Hemodialysis Int. 2005;(4, Suppl 1):S25–S29
  19. U.S. Renal Data System. USRDS 2005 annual data report; atlas of end-stage renal disease in the United States. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health; 2005;
  20. Scragg R, Sowers MF, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination survey. Diabetes Care. 2004;27:2813–2818
  21. Merlino LA, Curtis J, Mikuls TR, et al. Iowa Women's Health Study. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum. 2004;50:72–77
  22. Broe KE, Chen TC, Weinberg J, et al. A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc. 2007;55:234–239
  23. Mittal SK, Ahern L, Flaster E, et al. Self-assessed physical and mental function of haemodialysis patients. Nephrol Dial Transplant. 2001;16:1387–1394
  24. Kalantar-Zadeh K, Kopple JD, Block G, et al. Association among SF36 quality of life measures and nutrition, hospitalization, and mortality in hemodialysis. J Am Soc Nephrol. 2001;12:2797–2806
  25. National Kidney Foundation. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis. 2003;42(Suppl):S1–S201
  26. Deville J, Thorp M, Tobin L, et al. Effect of ergocalciferol supplementation on serum parathyroid hormone and serum 25-hydroxyvitamin D in chronic kidney disease. Nephrology. 2006;11:555–559
  27. Saab G, Young DO, Gincherman Y, et al. Prevalence of vitamin D deficiency and the safety and effectiveness of monthly ergocalciferol in hemodialysis patients. Nephron Clin Pract. 2007;105:c132–c138
  28. Zisman AL, Hristova M, Ho LT. Impact of ergocalciferol treatment of vitamin D deficiency on serum parathyroid concentrations in chronic kidney disease. Am J Nephrol. 2007;27:36–43
  29. Shah N, Bernardini J, Piraino B. Prevalence and correction of 25(OH) vitamin D deficiency in peritoneal dialysis patients. Perit Dial Int. 2005;25:362–366
  30. Remuzzi A. Vitamin D, insulin resistance, and renal disease. Kidney Int. 2007;71:96–98
  31. Borissova AM, Tankova T, Kirilov G, et al. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract. 2003;57:258–261
  32. Chiu KC, Chu A, Go VLW, et al. Hypovitaminosis D is associated with insulin resistance and β cell dysfunction. Am J Clin Nutr. 2004;79:820–825
  33. Norman AW, Frankel JB, Heldt AM, et al. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science. 1980;209:823–825
  34. Riachy R, Vanderwalle B, Belaich S, et al. Beneficial effects of 1,25 hydroxyvitamin D3 on cytokine treated human pancreatic cells. J Endocrinol. 2001;169:161–168
  35. Strutton DR, Stang PE, Erbey JR, et al. Estimated coronary heart disease attributable to insulin resistance in populations with and without type 2 diabetes mellitus. Am J Managed Care. 2001;7:765–773
  36. National Kidney Foundation. KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. Am J Kidney Dis. 2007;49(Suppl 2):S1–S179
  37. Kalantar-Zadeh K, Kopple JD, Regidor DL, et al. A1c and survival in maintenance hemodialysis patients. Diabetes Care. 2007;30:1049–1055

PII: S1051-2276(08)00301-4

doi: 10.1053/j.jrn.2008.04.008

Journal of Renal Nutrition
Volume 18, Issue 4 , Pages 375-382 , July 2008