Journal of Renal Nutrition
Volume 18, Issue 5 , Pages 400-407 , September 2008

Vitamin D Binding Protein and the Need for Vitamin D in Hemodialysis Patients

  • Marijn M. Speeckaert, MD

      Affiliations

    • Department of Clinical Chemistry, University of Ghent, Ghent University Hospital, Ghent, Belgium
    • ,
  • Griet L. Glorieux, PhD

      Affiliations

    • Department of Nephrology, University of Ghent, Ghent University Hospital, Ghent, Belgium
    • ,
  • Raymond Vanholder, MD, PhD

      Affiliations

    • Department of Nephrology, University of Ghent, Ghent University Hospital, Ghent, Belgium
    • ,
  • Wim Van Biesen, MD, PhD

      Affiliations

    • Department of Nephrology, University of Ghent, Ghent University Hospital, Ghent, Belgium
    • ,
  • Youri E. Taes, MD, PhD

      Affiliations

    • Department of Endocrinology, University of Ghent, Ghent University Hospital, Ghent, Belgium
    • ,
  • Frédéric Clement, MT

      Affiliations

    • Department of Clinical Chemistry, University of Ghent, Ghent University Hospital, Ghent, Belgium
    • ,
  • Charline Wehlou, MB, Ch B

      Affiliations

    • Department of Clinical Chemistry, University of Ghent, Ghent University Hospital, Ghent, Belgium
    • ,
  • Joris R. Delanghe, MD, PhD

      Affiliations

    • Department of Clinical Chemistry, University of Ghent, Ghent University Hospital, Ghent, Belgium
    • Corresponding Author InformationAddress reprint requests to Joris R. Delanghe, MD, PhD, Department of Clinical Chemistry, University of Ghent, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.

References 

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  2. Speeckaert M, Huang G, Delanghe JR, Taes YE. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta. 2006;372:33–42
  3. Brown AJ. Regulation of vitamin D action. Nephrol Dial Transplant. 1999;14:11–16
  4. Arnaud J, Constans J. Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP). Hum Genet. 1993;92:183–188
  5. Constans J, Viau M, Bouissou C. Affinity differences for the 25-OH-D3 associated with the genetic heterogeneity of the vitamin D-binding protein. FEBS Lett. 1980;111:107–111
  6. Andress DL. Vitamin D treatment in chronic kidney disease. Semin Dial. 2005;18:315–321
  7. Slatopolsky ES, Brown AJ. Vitamin D and renal failure. In:  Feldman D,  Glorieux FH,  Pike JW editor. Vitamin D. San Diego: Academic Press; 1997;p. 849–865
  8. Schömig M, Ritz E. Management of disturbed calcium metabolism in uraemic patients: 1. Use of vitamin D metabolites. Nephrol Dial Transplant. 2000;15:18–24
  9. Haughton MA, Mason RS. Immunonephelometric assay of vitamin D-binding protein. Clin Chem. 1992;38:1796–1801
  10. Clive DR, Sudhaker D, Giacherio D, et al. Analytical and clinical validation of a radioimmunoassay for the measurement of 1,25 dihydroxy vitamin D. Clin Biochem. 2002;35:517–521
  11. K/DOQI, National Kidney Foundation . Clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis. 2000;35(Suppl):S1–S140
  12. Constans J, Cleve H. Identification of group specific component/vitamin D-binding protein (GC/DBP) mutants by isoelectric focusing in immobilized pH gradients. Electrophoresis. 1988;9:599–602
  13. Parker WC, Cleve H, Bearn AG. Determination of phenotypes in the human group-specific component (GC) system by starch gel electrophoresis. Am J Hum Genet. 1963;15:353–367
  14. Kamboh MI, Ferrell RE. Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations. Hum Genet. 1986;72:281–293
  15. Lauridsen AL, Vestergaard P, Hermann AP, et al. Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women. Calcif Tissue Int. 2005;77:15–22
  16. Lauridsen AL, Vestergaard P, Nexo E. Mean serum concentration of vitamin D-binding protein (Gc globulin) is related to the Gc phenotype in women. Clin Chem. 2001;47:753–756
  17. Taes YE, Goemaere S, Huang G, et al. Vitamin D binding protein, bone status and body composition in community-dwelling elderly men. Bone. 2006;38:701–707
  18. Kawakami M, Blum CB, Ramakrishnan R, Dell RB, Goodman DS. Turnover of the plasma binding protein for vitamin D and its metabolites in normal human subjects. J Clin Endocrinol Metab. 1981;53:1110–1116
  19. Bouillon R, van Baelen H, de Moor P. The measurement of the vitamin D-binding protein in human serum. J Clin Endocrinol Metab. 1997;45:225–231
  20. Meier U, Gressner O, Lammert F, Gressner AM. Gc-globulin: roles in response to injury. Clin Chem. 2006;52:1247–1253
  21. Gressner O, Meier U, Hillebrandt S, et al. Gc-globulin concentrations and C5 haplotype-tagging polymorphisms contribute to variations in serum activity of complement factor C5. Clin Biochem. 2007;40:771–775
  22. Nykjaer A, Dragun D, Walther D, et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell. 1999;96:507–515
  23. Nykjaer A, Fyce JC, Kozyraki R, et al. Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH)vitamin D(3). Proc Natl Acad Sci USA. 2001;98:13895–13900
  24. St. John A, Thomas MB, Davies CP, et al. Determinants of intact parathyroid hormone and free 1,25-dihydroxyvitamin D levels in mild and moderate renal failure. Nephron. 1992;61:422–427
  25. Yonemura K, Sugiura T, Yamashita F, Matsushima H, Hishida A. Supplementation with alfacalcidol increases protein intake and serum albumin concentration in patients undergoing hemodialysis with hypoalbuminemia. Blood Purif. 2004;22:210–215

PII: S1051-2276(08)00310-5

doi: 10.1053/j.jrn.2008.04.013

Journal of Renal Nutrition
Volume 18, Issue 5 , Pages 400-407 , September 2008

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