Journal of Renal Nutrition
Volume 19, Issue 2 , Pages 167-171 , March 2009

Effect of Megestrol Acetate on Serum Albumin Level in Malnourished Dialysis Patients

References 

  1. Kalantar-Zadeh K, Block GJ, McAllister C, et al. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr. 2004;80:299–307
  2. Morley EJ, Thomas RD, Mary G, Wilson M. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr. 2006;83:735–743
  3. Masud T, Mitzh WE: Nutrition in end stage renal diseases. In: Pereira BJG, Sayegh MH, Blake P, editors: Chronic kidney disease, dialysis and transplantation. Second edition. Philadelphia, Saunders, pp 214–231
  4. Rammohan M, Kalantar-Zadeh K, Liang A, et al. Megestrol acetate in a moderate dose for the treatment of malnutrition-inflammation complex in maintenance dialysis patients. J Ren Nutr. 2005;15:345–355
  5. Ohri-Vachaspati P, Sehgal AR. Correlation of poor appetite among hemodialysis patients. J Ren Nutr. 1999;9:182–185
  6. Carrero JJ, Qureshi AR, Axelsson J, et al. Comparison of nutritional and inflammatory markers in dialysis patients with reduced appetite. Am J Clin Nutr. 2007;85:695–701
  7. Scheyla José dos Santos N, Antonio Draibe S, Ayako Kamimura M, et al. Is serum albumin a marker of nutritional status in hemodialysis patients without evidence of inflammation?. Artif Organs. 2003;27:681–686
  8. Available in: http://www.cancercare.on.ca/pdfdrugs/MEGESTRO.pdf
  9. Femia RA. Goyette R, Richert E: The science of megestrol acetate delivery: potential to improve outcomes in cachexia. Biodrugs. 2005;19:179–187
  10. Cronin RE, Henrich WL. Protein catabolic rate in maintenance dialysis. Up to date. 2007;15.3:
  11. Carrero JJ, Aguilera A, Stenvinkel P, et al. Appetite disorders in uremia. J Ren Nutr. 2008;18:107–113
  12. Loprinzi CL, Bernath AM, Schaid DJ, et al. Phase III evaluation of 4 doses of megestrol acetate at therapy for patients with cancer anorexia and/or cachexia. Oncology. 1994;51:2–7
  13. Aguilera A, Selgas R, Diez JJ, et al. Anorexia in end-stage renal diseases: pathophysiology and treatment. Expert Opin Pharmacother. 2001;2:1825–1838
  14. Lein YH, Ruffenach SJ. Low dose megestrol increases serum albumin in malnourished dialysis patients. Int J Artif Organs. 1996;19:147–150
  15. Boccanfuso JA, Hutton M, McAllister B. The effects of megestrol acetate on nutritional parameters in a dialysis population. J Ren Nutr. 2000;10:36–43
  16. Costero O, Bajo MA, del Peso G, et al. Treatment of anorexia and malnutrition in peritoneal dialysis patients with megestrol acetate. Adv Perit Dial. 2004;20:209–212

PII: S1051-2276(08)00460-3

doi: 10.1053/j.jrn.2008.11.003

Journal of Renal Nutrition
Volume 19, Issue 2 , Pages 167-171 , March 2009