Effects of Soy Consumption on Oxidative Stress, Blood Homocysteine, Coagulation Factors, and Phosphorus in Peritoneal Dialysis Patients
published online 06 July 2009.
Objective
We studied the effects of soy consumption on oxidative stress, blood homocysteine, coagulation factors, and phosphorus in peritoneal dialysis patients.
Design
This was an unblinded, randomized clinical trial.
Setting
This study involved peritoneal dialysis centers in Tehran, Iran.
Patients
We included 40 peritoneal dialysis patients (20 males and 20 females).
Intervention
Peritoneal dialysis patients were randomly assigned to either a soy or control group. Patients in the soy group received 28 g/day textured soy flour (containing 14 g of soy protein) for 8 weeks, whereas patients in the control group received their usual diet, without any soy.
Main Outcome Measures
Blood oxidized low-density lipoprotein (ox-LDL), homocysteine, phosphorus, fibrinogen concentrations, and the activities of coagulation factors VII, IX, and X were measured at baseline and at the end of week 8 of the study.
Results
The percentage of plasma coagulation factor IX activity decreased significantly by 17% in the soy group at the end of week 8 compared with baseline (P < .01), and the reduction was significant compared with the control group (P < .05). There were no significant differences between the two groups in mean changes of blood ox-LDL, homocysteine, phosphorus, fibrinogen concentrations, and the activities of coagulation factors VII and X.
Conclusion
Soy consumption reduces plasma coagulation factor IX activity, which is a risk factor for thrombosis in peritoneal dialysis patients.
∗Department of Human Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Islamic Republic of Iran
†Department of Human Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Islamic Republic of Iran
‡Department of Nephrology, Shaheed Modares Hospital, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Islamic Republic of Iran
§Department of Nursing, Shaheed Modares Hospital, Tehran, Islamic Republic of Iran
¶Iranian Blood Transfusion Organization, Tehran, Islamic Republic of Iran
#Endocrine Research Center, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Islamic Republic of Iran
Address reprint requests to Hadi Tabibi, Department of Human Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, 46 West Arghavan St., Farahzadi Blvd., Shahrak Qods, PO, Box 19395-4741 Tehran, Islamic Republic of Iran.
This study was supported by the National Nutrition and Food Technology Research Institute of Iran.
ABSTRACT