Journal of Renal Nutrition
Volume 20, Issue 1 , Pages 38-43 , January 2010

Impact of Metabolic Syndrome and Malnutrition on Mortality in Chronic Hemodialysis Patients

  • Radojica V. Stolic, MD, PhD

      Affiliations

    • Kosovska Mitrovica Internal Clinic, University of Pristina/K. Mitrovica, Faculty of Medicine Pristina/K. Mitrovica, Anri Dinana bb, Kosovska, Mitrovica, Serbia
    • Corresponding Author InformationAddress reprint requests to Radojica Stolic, MD, PhD, Kosovska Mitrovica Internal Clinic, Faculty of Medicine, Anri Dinana bb, 38220 Kosovska, Mitrovica, Serbia.
    • ,
  • Goran Z. Trajkovic, MD, PhD

      Affiliations

    • Institute of Medical Statistics and Informatics, Faculty of Medicine Pristina/Kosovska Mitrovica, University of Pristina/K. Mitrovica, Kosovska, Mitrovica, Serbia
    • ,
  • Vladan M. Peric, MD

      Affiliations

    • Kosovska Mitrovica Internal Clinic, University of Pristina/K. Mitrovica, Faculty of Medicine Pristina/K. Mitrovica, Anri Dinana bb, Kosovska, Mitrovica, Serbia
    • ,
  • Dragica Z. Stolic, MD

      Affiliations

    • Health Center Pristina, Gracanica, Serbia
    • ,
  • Sasa R. Sovtic, MD, PhD

      Affiliations

    • Kosovska Mitrovica Internal Clinic, University of Pristina/K. Mitrovica, Faculty of Medicine Pristina/K. Mitrovica, Anri Dinana bb, Kosovska, Mitrovica, Serbia
    • ,
  • Jovanovic N. Aleksandar, MD, PhD

      Affiliations

    • Kosovska Mitrovica Internal Clinic, University of Pristina/K. Mitrovica, Faculty of Medicine Pristina/K. Mitrovica, Anri Dinana bb, Kosovska, Mitrovica, Serbia
    • ,
  • Gordana Dj. Subaric-Gorgieva, MD, PhD

      Affiliations

    • Kosovska Mitrovica Internal Clinic, University of Pristina/K. Mitrovica, Faculty of Medicine Pristina/K. Mitrovica, Anri Dinana bb, Kosovska, Mitrovica, Serbia

References 

  1. Tuttle KR. Renal manifestations of the metabolic syndrome. Nephrol Dial Transplant. 2005;20:861–864
  2. Kuk JL, Church TS, Blair SN, et al. Does measurement site for visceral and abdominal subcutaneous adipose tissue alter associations with the metabolic syndrome?. Diabetes Care. 2006;29:679–684
  3. Segura J, Campo C, Roldan C, et al. Hypertensive renal damage in metabolic syndrome is associated with glucose metabolism disturbances. J Am Soc Nephrol. 2004;15(Suppl 1):37–42
  4. Young DO, Lund RJ, Haynatzki G, et al. Prevalence of the metabolic syndrome in an incident dialysis population. Hemodialysis International. 2007;11:86–95
  5. Chazot C, Laurent G, Charra B, et al. Malnutrition in long-term haemodialysis survivors. Nephrol Dial Transplant. 2001;16:61–69
  6. Bradbury BD, Fissell RB, Albert JM, et al. Predictors of early mortality among incident US hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Clin J Am Soc Nephrol. 2007;2:89–99
  7. Seliger SL, Gillen DL, Tirschwell D, et al. Risk factors for incident stroke among patients with end-stage renal disease. J Am Soc Nephrol. 2003;14:2623–2631
  8. Ikizler TA, Pupim LB, Brouillette JR, et al. Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation. Am J Physiol Endocrinol Metab. 2002;282:107–116
  9. Pifer TB, Mccullough KP, Port FK, et al. Mortality risk in hemodialysis patients and changes in nutritional indicators: DOPPS. Kidney Int. 2002;62:2238–2245
  10. Johansen KL, Kaysen GA, Young BS, et al. Longitudinal study of nutritional status, body composition, and physical function in hemodialysis patients. Am J Clin Nutr. 2003;4:842–846
  11. Jager KJ, Merkus MP, Huisman RM, et al. Necosad Study Group. Nutritional status over time in hemodialysis and peritoneal dialysis. J Am Soc Nephrol. 2001;12:1272–1279
  12. Hecking E, Bragg-Gresham JL, Rayner HC, et al. Haemodialysis prescription, adherence and nutritional indicators in five European countries: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant. 2004;19:100–107
  13. Stenvinkel P, Heimbürger O, Lindholm B. Wasting, but not malnutrition, predicts cardiovascular mortality in end-stage renal disease. Nephrol Dial Transplant. 2004;19:2181–2183
  14. Johnson DW, Craven AM, Isbel NM. Modification of cardiovascular risk in hemodialysis patients: an evidence-based review. Hemodialysis Int. 2007;11:1–14
  15. Qureshi AR, Alvestrand A, Divino-Filho JC, et al. Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients. J Am Soc Nephrol. 2002;13:28–36
  16. Beddhu S, Pappas LM, Ramkumar N, et al. Malnutrition and atherosclerosis in dialysis patients. J Am Soc Nephrol. 2004;15:733–742
  17. Spiegel DM, Raggi P, Smits G, et al. Factors associated with mortality in patients new to haemodialysis. Nephrol Dial Transplant. 2007;22:3568–3572
  18. Kalantar-Zadeh K, Kuwae N, Wu DY, et al. Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients. Am J Clin Nutr. 2006;83:202–210

PII: S1051-2276(09)00043-0

doi: 10.1053/j.jrn.2009.01.021

Journal of Renal Nutrition
Volume 20, Issue 1 , Pages 38-43 , January 2010

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