Journal of Renal Nutrition
Volume 19, Issue 4 , Pages 267-274 , July 2009

Comparison of Fatty Acid Contents of Erythrocyte Membrane in Hemodialysis and Peritoneal Dialysis Patients

  • W.S. An, MD

      Affiliations

    • Department of Internal Medicine, Dong-A University, Busan, Republic of Korea
    • ,
  • S.E. Kim, MD

      Affiliations

    • Department of Internal Medicine, Dong-A University, Busan, Republic of Korea
    • ,
  • K.H. Kim, MD

      Affiliations

    • Department of Internal Medicine, Dong-A University, Busan, Republic of Korea
    • ,
  • S. Lee, MD

      Affiliations

    • Department of Family Medicine and Medical Research Institute, Pusan National University, Busan, Republic of Korea
    • ,
  • Y. Park, PhD

      Affiliations

    • Department of Food and Nutrition, Hanyang University, Seoul, Republic of Korea
    • ,
  • H.J. Kim, PhD

      Affiliations

    • Division of Nephrology and Hypertension, University of California, Irvine, CA
    • ,
  • N.D. Vaziri, MD

      Affiliations

    • Division of Nephrology and Hypertension, University of California, Irvine, CA
    • Corresponding Author InformationAddress reprint requests to N. D. Vaziri, MD. Division of Nephrology and Hypertension, UCI Medical Center, 101 The City Drive, Building 53, Room 125, Route 81, Orange, CA 92868.

References 

  1. Foley RN. Clinical epidemiology of cardiac disease in dialysis patients: left ventricular hypertrophy, ischemic heart disease, and cardiac failure. Semin Dial. 2003;16:111–117
  2. Keith DS, Nichols GA, Gullion CM, et al. Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med. 2004;164:659–663
  3. GISSI-Prevenzione Investigators. Dietary supplementation with omega-3 polyunsaturated fatty acids and vitamin E in 11,324 patients with myocardial infarction: results of the GISSI-Prevenzione trial. Lancet. 1999;354:447–455
  4. Kang JX, Xiao YF, Leaf A. Free long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 1995;92:3997–4001
  5. Leaf A. The electrophysiologic basis for the antiarrhythmic and anticonvulsant effects of n-3 polyunsaturated fatty acids: heart and brain. Lipids. 2001;36(suppl):S107–S110
  6. Leaf A, Kang JX, Xiao YF, et al. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation. 2003;107:2646–2652
  7. Harris WS, Sands SA, Windsor SL, et al. Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. Circulation. 2004;21:1645–1649
  8. Dasgupta A, Kenny MA, Ahmad S. Abnormal fatty acid profile in chronic hemodialysis patients: Possible deficiency of essential fatty acids. Clin Physiol Biochem. 1990;8:238–243
  9. Peck LW, Monsen ER, Ahmad S. Effect of three sources of long-chain fatty acids on the plasma fatty acid profile, plasma prostaglandin E2 concentrations, and pruritus symptoms in hemodialysis patients. Am J Clin Nutr. 1996;64:210–214
  10. Varga Z, Karpati I, Paragh G, Buris L, et al. Relative abundance of some free fatty acids in plasma of uremic patients: relationship between fatty acids, lipid parameters, and diseases. Nephron. 1997;77:417–421
  11. Koorts AM, Viljoen M, Kruger MC. Red blood cell fatty acid profile of chronic renal failure patients receiving maintenance haemodialysis treatment. Prostaglandins Leukot Essent Fatty Acids. 2002;67:13–18
  12. Friedman AN, Moe SM, Perkins SM, et al. Fish consumption and omega-3 fatty acid status and determinants in long-term hemodialysis. Am J Kidney Dis. 2006;47:1064–1071
  13. Kromhout D. N-3 fatty acids and coronary heart disease: epidemiology from Eskimos to Western populations. J Intern Med Suppl. 1989;731:47–51
  14. Koorts AM, Viljoen M, Kruger MC. Red blood cell fatty acid profile of chronic renal failure patients receiving maintenance haemodialysis treatment. Prostaglandins Leukot Essent Fatty Acids. 2002;67:13–18
  15. Harris WS, Von Schacky C. The omega-3 index: a new risk factor for death from coronary heart disease?. Prev Med. 2004;39:212–220
  16. DeFillipis AP, Sperling LA. Understanding omega-3's. Am Heart J. 2006;151:564–570
  17. Egan BM, Lu G, Greene EL. Vascular effects of non-esterified fatty acids: implications for the cardiovascular risk factor cluster. Prostaglandins Leukot Essent Fatty Acids. 1999;60:411–420
  18. Lu G, Greene EL, Nagai T, et al. Reactive oxygen species are critical in the oleic acid-mediated mitogenic signaling pathway in vascular smooth muscle cells. Hypertension. 1998;32:1003–1011
  19. Nestel P, Clifton P, Noakes M. Effects of increasing dietary palmitoleic acid compared with palmitic and oleic acids on plasma lipids of hypercholesterolemic men. J Lipid Res. 1994;35:656–662
  20. Sarabi M, Vessby B, Millgard J, Lind L. Endothelium-dependent vasodilation is related to the fatty acid composition of serum lipids in healthy subjects. Atherosclerosis. 2001;156:349–355
  21. Saifullah A, Watkins BA, Saha C, et al. Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients: a pilot study. Nephrol Dial Transplant. 2007;22:3561–3567
  22. Burns T, Maciejewski SR, Hamilton WR, et al. Effect of omega-3 fatty acid supplementation on the arachidonic acid:eicosapentaenoic acid ratio. Pharmacotherapy. 2007;27:633–638

 This study was supported by research funds from Dong-A University.

PII: S1051-2276(09)00049-1

doi: 10.1053/j.jrn.2009.01.027

Journal of Renal Nutrition
Volume 19, Issue 4 , Pages 267-274 , July 2009

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