Journal of Renal Nutrition
Volume 19, Issue 6 , Pages 487-493 , November 2009

Effect of Intradialytic Intravenous Administration of ω-3 Fatty Acids on Nutritional Status and Inflammatory Response in Hemodialysis Patients: A Pilot Study

  • Magdalena Szklarek-Kubicka, MD

      Affiliations

    • Department of Nephrology, Hypertension, and Kidney Transplantation, Medical University of Łódź, Łódź, Poland
  • ,
  • Jolanta Fijałkowska-Morawska, MD

      Affiliations

    • Department of Nephrology, Hypertension, and Kidney Transplantation, Medical University of Łódź, Łódź, Poland
  • ,
  • Danuta Zaremba-Drobnik, MD

      Affiliations

    • Department of Nephrology, Medical University, Poznań, Poland
  • ,
  • Andrzej Uciński, MD

      Affiliations

    • Dialysis Center, Bełchatów, Poland
  • ,
  • Stanisław Czekalski, MD

      Affiliations

    • Department of Nephrology, Medical University, Poznań, Poland
  • ,
  • Michał Nowicki, MD

      Affiliations

    • Department of Nephrology, Hypertension, and Kidney Transplantation, Medical University of Łódź, Łódź, Poland
    • Corresponding Author InformationAddress reprint requests to Michał Nowicki, MD, Department of Nephrology, Hypertension, and Kidney Transplantation, Medical University of Łódź, Kopcinskiego 22, Łódź 91-156, Poland.

References 

  1. Brunner FP, Selwood NH. Profile of patients on RRT in Europe and death rates due to major causes of death groups. The EDTA Registration Committee. Kidney Int. 1992;38(Suppl):S4–S15
  2. National Institutes of Health: United States Renal Data System: Annual Data Report. Atlas of End-Stage Renal Disease in the United States. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD:. 2005;121–144
  3. Aparicio M, Cano N, Chauveau P. Nutritional status of haemodialysis patients: a French national cooperative study. French Study Group for Nutrition in Dialysis. Nephrol Dial Transplant. 1999;14:679–686
  4. Leave SF, Strawderman RL, Jones CA, et al. Simple nutritional indicators as independent predictors of mortality in hemodialysis patients. Am J Kidney Dis. 1998;31:997–1006
  5. Marckmann P. Nutritional status of patients on hemodialysis and peritoneal dialysis. Clin Nephrol. 1988;29:75–78
  6. Qureshi AR, Alvestrand A, Danielsson A, et al. Factors predicting malnutrition in hemodialysis patients: a cross-sectional study. Kidney Int. 1998;53:773–782
  7. Qureshi AR, Alvestrand A, Divino-Filho JC, et al. Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients. J Am Soc Nephrol. 2002;13(Suppl):S28–S36
  8. Stenvinkel P, Heimburger O, Lindholm B, et al. Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant. 2000;15:953–960
  9. Kimmel PL, Phillips TM, Simmens SJ. Immunologic function and survival in hemodialysis patients. Kidney Int. 1998;54:236–244
  10. Holub BJ. Clinical nutrition: 4. Omega-3 fatty acids in cardiovascular care. Can Med Assoc J. 2002;166:608–615
  11. Jump DB. The biochemistry of n-3 polyunsaturated fatty acids. J Biol Chem. 2002;15:8755–8758
  12. Mayser P, Mayer K, Mahloudjian M, et al. A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis. J Parenter Enteral Nutr. 2002;26:151–158
  13. Grimminger F, Mayser P, Papavassilis C, et al. A double-blind, randomized, placebo-controlled trial of n-3 fatty acid based lipid infusion in acute, extended guttate psoriasis. Rapid improvement of clinical manifestations and changes in neutrophil leukotriene profile. Clin Invest. 1993;71:634–643
  14. Mayser P, Mrowietz U, Arenberger P, et al. Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial. J Am Acad Dermatol. 1998;38:539–547
  15. Grimminger F, Fuhrer D, Papavassilis C, et al. Influence of intravenous n-3 lipid supplementation on fatty acid profiles and lipid mediator generation in a patient with severe ulcerative colitis. Eur J Clin Invest. 1993;23:706–715
  16. Mayer K, Gokorsch S, Fegbeutel C, et al. Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. Am J Respir Crit Care Med. 2003;167:1321–1328
  17. Donadio JV, Bergstralh EJ, Offord KP, et al. A controlled trial of fish oil in IgA nephropathy. Mayo Nephrology Collaborative Group. N Engl J Med. 1994;331:1194–1199
  18. Donadio JV, Grande JP, Bergstralh EJ, et al. The long-term outcome of patients with IgA nephropathy treated with fish oil in a controlled trial. Mayo Nephrology Collaborative Group. J Am Soc Nephrol. 1999;10:1772–1777
  19. Schmitz PG, McCloud LK, Reikes ST, et al. Prophylaxis of hemodialysis graft thrombosis with fish oil: double-blind, randomized, prospective trial. J Am Soc Nephrol. 2002;13:184–190
  20. Svensson M, Christensen JH, Solling J, et al. The effect of n-3 fatty acids on plasma lipids and lipoproteins and blood pressure in patients with CRF. Am J Kidney Dis. 2004;44:77–83
  21. Saifullah A, Watkins BA, Saha C, et al. Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients—a pilot study. Nephrol Dial Transplant. 2007;22:3561–3567
  22. Perunicic-Pekovic G, Rasic ZR, Pljesa SI, et al. Effect of ω-3 fatty acids on nutritional status and inflammatory markers in haemodialysis patients. Nephrology. 2007;12:331–336
  23. Kalantar-Zadeh K, Braglia A, Chow J, et al. An anti-inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: a pilot/feasibility study. J Ren Nutr. 2005;15:318–331
  24. Levy J, Morgan J, Brown E. Handbook of Dialysis. Oxford: Oxford University Press; 2001;
  25. Depner TA, Deugirdas JT. Equations for normalized protein catabolic rate based on two-point modeling of hemodialysis urea kinetics. J Am Soc Nephrol. 1996;7:780–785
  26. Kaysen GA, Stevenson FT, Depner TA. Determinants of albumin concentration in hemodialysis patients. Am J Kidney Dis. 1997;29:658–668
  27. Mayer K, Meyer S, Reinholz-Muhly M, et al. Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans. J Immunol. 2003;10:4837–4843
  28. Svensson M, Schmidt EB, Jorgensen KA, et al. N-3 fatty acids as secondary prevention against cardiovascular events in patients who undergo chronic hemodialysis: a randomized, placebo-controlled intervention trial. Clin J Am Soc Nephrol. 2006;1:780–786
  29. Danno K, Sugie N. Combination therapy with low-dose etretinate and eicosapentaenoic acid for psoriasis vulgaris. J Dermatol. 1998;25:703–705
  30. Senkal M, Mumme A, Eickhoff U, et al. Early postoperative enteral immunonutrition: clinical outcome and cost-comparison analysis in surgical patients. Crit Care Med. 1997;25:1489–1496
  31. Soyland E, Funk J, Rajka G, et al. Effect of dietary supplementation with very-long-chain n-3 fatty acids in patients with psoriasis. N Engl J Med. 1993;328:1812–1816
  32. Rysz J, Banach M, Ciałkowska-Rysz A, et al. Blood serum levels of IL-2, IL-6, IL-8, TNF-alpha and IL-1beta in patients on maintenance hemodialysis. Cell Mol Immunol. 2006;3:151–154

PII: S1051-2276(09)00139-3

doi: 10.1053/j.jrn.2009.05.007

Journal of Renal Nutrition
Volume 19, Issue 6 , Pages 487-493 , November 2009