Journal of Renal Nutrition
Volume 20, Issue 3 , Pages 151-157 , May 2010

Are Ghrelin and Leptin Involved in Food Intake and Body Mass Index in Maintenance Hemodialysis?

  • Denise Mafra, PhD

      Affiliations

    • Department of Clinical Nutrition, Nutrition Faculty, Federal University Fluminense, Niterói, Brazil
    • Department of Nephrology, Hôpital Edouard Herriot, and Institut National de la Santé et de la Recherche Médicale U870, University of Lyon 1, Lyon, France
    • ,
  • Anne Jolivot, MD

      Affiliations

    • Department of Nephrology, Hôpital Edouard Herriot, and Institut National de la Santé et de la Recherche Médicale U870, University of Lyon 1, Lyon, France
    • ,
  • Philippe Chauveau, PhD

      Affiliations

    • Association Utilisation Rein Artificiel à Domicile Bordeaux, Bordeaux, France
    • ,
  • Jocelyne Drai, PharmD

      Affiliations

    • Department of Biochemistry, Centre Hospitalier et Universitaire Lyon Sud, Pierre Bénite, France
    • ,
  • Raymond Azar, MD

      Affiliations

    • Centre Hospitalier Dunkerque, Dunkirk, France
    • ,
  • Catherine Michel, MD

      Affiliations

    • AURA Paris, Paris, France
    • ,
  • Denis Fouque, MD, PhD

      Affiliations

    • Department of Nephrology, Hôpital Edouard Herriot, and Institut National de la Santé et de la Recherche Médicale U870, University of Lyon 1, Lyon, France
    • Corresponding Author InformationAddress reprint requests to Denis Fouque, MD, PhD, Department of Nephrology, Hôpital Edouard Herriot, 69437 Lyon Cedex 03, France.

References 

  1. Mak RH, Cheung W, Cone RD, et al. Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease. Pediatr Nephrol. 2005;20:427–431
  2. Friedman M. Leptin, leptin receptors and the control of body weight. Eur J Med Res. 1997;2:7–13
  3. Van Heek M, Compton DS, France CF, et al. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest. 1997;99:385–390
  4. El-Haschimi K, Pierroz DD, Hileman SM, et al. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest. 2000;105:1827–1832
  5. Don BR, Rosales LM, Levine NW, et al. Leptin is a negative acute phase protein in chronic hemodialysis patients. Kidney Int. 2001;59:1114–1120
  6. Leontiou CA, Franchi G, Korbonits M. Ghrelin in neuroendocrine organs and tumours. Pituitary. 2007;10:213–225
  7. Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 2001;141:4325–4328
  8. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656–660
  9. Van der Lely AJ, Tschop M, Heiman ML, et al. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004;25:426–457
  10. Nishi Y, Hiejima H, Hosoda H, et al. Ingested medium-chain fatty acids are directly utilized for the acyl-modification of ghrelin. Endocrinology. 2005;146:2255–2264
  11. Hosoda H, Kojima M, Matsuo H, et al. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun. 2000;279:909–913
  12. Asakawa A, Inui A, Fujimiya M, et al. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut. 2005;54:18–24
  13. Chang CC, Hung CH, Yen CS, et al. The relationship of plasma ghrelin level to energy regulation, feeding and left ventricular function in non-diabetic haemodialysis patients. Nephrol Dial Transplant. 2005;20:2172–2177
  14. Daugirdas JT, Depner TA, Gotch FA, et al. Comparison of methods to predict equilibrated Kt/V in the HEMO Pilot Study. Kidney Int. 1997;52:1395–1405
  15. Kopple JD, Jons MR, Keshaviah PR, et al. A proposed glossary for dialysis kinetics. Am J Kidney Dis. 1995;26:963–981
  16. Keys A, Fidanza F, Kcarvonen MJ. Indices of relative weight and obesity. J Chronic Dis. 1972;25:329–343
  17. Mak RH, Cheung W, Cone RD, et al. Mechanisms of disease: cytokine and adipokine signaling in uremic cachexia. Nat Clin Pract Nephrol. 2006;2:527–534
  18. Wright M, Woodrow G, O'Brien S, et al. Cholecystokinin and leptin: their influence upon the eating behaviour and nutrient intake of dialysis patients. Nephrol Dial Transplant. 2004;19:133–140
  19. Dervisoglu E, Eraldemir C, Kalender B, et al. Adipocytokines leptin and adiponectin, and measures of malnutrition-inflammation in chronic renal failure: is there a relationship?. J Ren Nutr. 2008;18:332–337
  20. Yoshimoto A, Mori K, Sugawara A, et al. Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol. 2002;13:2748–2752
  21. Tentolouris N, Makrilakis K, Doulgerakis D, et al. Increased plasma ghrelin levels in chronic renal failure are not associated with hemodynamic parameters. Horm Metab Res. 2005;37:646–652
  22. Neary NM, Druce MR, Small CJ, et al. Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect. Gut. 2006;55:135
  23. Muscaritoli M, Molfino A, Chiappini MG, et al. Anorexia in hemodialysis patients: the possible role of des-acyl ghrelin. Am J Nephrol. 2007;27:360–365
  24. Barazzoni R, Zanetti M, Stulle M, et al. Higher total ghrelin levels are associated with higher insulin-mediated glucose disposal in non-diabetic maintenance hemodialysis patients. Clin Nutr. 2008;27:142–149
  25. Ayala ER, Pecoits-Filho R, Heimbürger O, et al. Associations between plasma ghrelin levels and body composition in end-stage renal disease: a longitudinal study. Nephrol Dial Transplant. 2004;19:421–426
  26. Hotta M, Ohwada R, Katakami H, et al. Plasma level of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. J Clin Endocrinol Metab. 2004;89:5707–5712
  27. Soares JB, Leite-Moreira AF. Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides. 2008;29:1255–1270
  28. Deboer MD, Zhu X, Levasseur PR, et al. Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Endocrinology. 2008;149:827–835
  29. Li WG, Gavrila D, Liu X, et al. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation. 2004;109:2221–2226
  30. Endo M, Masaki T, Seike M, et al. Involvement of stomach ghrelin and hypothalamic neuropeptides in tumor necrosis factor-alpha-induced hypophagia in mice. Regul Pept. 2007;140:94–100
  31. Kamiji MM, Inui A. The role of ghrelin and ghrelin analogues in wasting disease. Curr Opin Clin Nutr Metab Care. 2008;11:443–451
  32. Giovambattista A, Gaillard RC, Spinedi E. Ghrelin gene-related peptides modulate rat white adiposity. Vitam Horm. 2008;77:171–205

PII: S1051-2276(09)00213-1

doi: 10.1053/j.jrn.2009.08.007

Journal of Renal Nutrition
Volume 20, Issue 3 , Pages 151-157 , May 2010

Article Tools

* Image Usage & Resolution