Journal of Renal Nutrition
Volume 20, Issue 1 , Pages 1-7 , January 2010

Systematic Review of Evidence for the Use of Intradialytic Parenteral Nutrition in Malnourished Hemodialysis Patients

  • Mhairi K. Sigrist, BSc, PhD

      Affiliations

    • Department of Nephrology, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada
    • Corresponding Author InformationAddress reprint requests to Mhairi K. Sigrist, Department of Nephrology, St. Paul's Hospital, University of British Columbia, Providence Health, 1081 Burrard St., Rm. 6010A, Vancouver, British Columbia, Canada. V6K 1C6.
    • ,
  • Adeera Levin, MD, FRCP

      Affiliations

    • Department of Nephrology, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada
    • ,
  • Aaron M. Tejani, BSc(pharm), PharmD, ACPR

      Affiliations

    • Clinical Research and Drug Information, Fraser Health Pharmacy Services, Fraser Valley, British Columbia, Canada

References 

  1. Aparicio M, Cano N, Chauveau P, et al. Nutritional status of haemodialysis patients: a French national cooperative study. French Study Group for Nutrition in Dialysis. Nephrol Dial Transplant. 1999;14:1679–1686
  2. Burrowes JD, Larive B, Chertow GM, et al. Self-reported appetite, hospitalization and death in haemodialysis patients: findings from the Hemodialysis (HEMO) Study. Nephrol Dial Transplant. 2005;20:2765–2774
  3. Dwyer JT, Larive B, Leung J, et al. Are nutritional status indicators associated with mortality in the Hemodialysis (HEMO) Study?. Kidney Int. 2005;68:1766–1776
  4. Hecking E, Bragg-Gresham JL, Rayner HC, et al. Haemodialysis prescription, adherence and nutritional indicators in five European countries: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant. 2004;19:100–107
  5. Teixeira Nunes F, de Campos G, Xavier de Paula SM, et al. Dialysis adequacy and nutritional status of hemodialysis patients. Hemodial Int. 2008;12:45–51
  6. Ikizler TA. Nutrition, inflammation and chronic kidney disease. Curr Opin Nephrol Hypertens. 2008;17:162–167
  7. Kalantar-Zadeh K, Block G, McAllister CJ, et al. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr. 2004;80:299–307
  8. Mehrotra R, Nolph KD. Treatment of advanced renal failure: low-protein diets or timely initiation of dialysis?. Kidney Int. 2000;58:1381–1388
  9. Foulks CJ. An evidence-based evaluation of intradialytic parenteral nutrition. Am J Kidney Dis. 1999;33:186–192
  10. Cano NJ, Fouque D, Roth H, et al. Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients: a 2-year multicenter, prospective, randomized study. J Am Soc Nephrol. 2007;18:2583–2591
  11. Capelli JP, Kushner H, Camiscioli TC, et al. Effect of intradialytic parenteral nutrition on mortality rates in end-stage renal disease care. Am J Kidney Dis. 1994;23:808–816
  12. Chertow GM, Ling J, Lew NL, et al. The association of intradialytic parenteral nutrition administration with survival in hemodialysis patients. Am J Kidney Dis. 1994;24:912–920
  13. Navarro JF, Mora C, Leon C, et al. Amino acid losses during hemodialysis with polyacrylonitrile membranes: effect of intradialytic amino acid supplementation on plasma amino acid concentrations and nutritional variables in nondiabetic patients. Am J Clin Nutr. 2000;71:765–773
  14. Oguz Y, Bulucu F, Vural A. Oral and parenteral essential amino acid therapy in malnourished hemodialysis patients. Nephron. 2001;89:224–227
  15. Wolfson M, Jones MR, Kopple JD. Amino acid losses during hemodialysis with infusion of amino acids and glucose. Kidney Int. 1982;21:500–506
  16. Bossola M, Muscaritoli M, Tazza L, et al. Malnutrition in hemodialysis patients: what therapy?. Am J Kidney Dis. 2005;46:371–386
  17. Kopple JD. Nutritional status as a predictor of morbidity and mortality in maintenance dialysis patients. ASAIO J. 1997;43:246–250
  18. Mortelmans AK, Vanholder R. Intradialytic parenteral nutrition in malnourished hemodialysis patients. Review of the literature. Miner Electrolyte Metab. 1999;25:324–332
  19. Wolfson M, Foulks CJ. Intradialytic parenteral nutrition: a useful therapy?. Nutr Clin Pract. 1996;11:5–11
  20. Cano N, Labastie-Coeyrehourq J, Lacombe P, et al. Predialytic parenteral nutrition with lipids and amino acids in malnourished hemodialysis patients. Am J Clin Nutr. 1990;52:726–730
  21. Guarnieri G, Faccini L, Lipartiti T, et al. Simple methods for nutritional assessment in hemodialyzed patients. Am J Clin Nutr. 1980;33:1598–1607
  22. Hecking E, Port FK, Brehm H, et al. A controlled study on the value of oral supplementation with essential amino acids and keto analogues in chronic hemodialysis. Proc Clin Dial Transplant Forum. 1977;7:157–161
  23. Hiroshige K, Iwamoto M, Kabashima N, et al. Prolonged use of intradialysis parenteral nutrition in elderly malnourished chronic haemodialysis patients. Nephrol Dial Transplant. 1998;13:2081–2087
  24. Dezfuli A, Scholl D, Lindenfeld SM, et al. Severity of hypoalbuminemia predicts response to intradialytic parenteral nutrition in hemodialysis patients. J Ren Nutr. 2009;19:291–297
  25. Pupim LB, Flakoll PJ, Ikizler TA. Nutritional supplementation acutely increases albumin fractional synthetic rate in chronic hemodialysis patients. J Am Soc Nephrol. 2004;15:1920–1926
  26. Pupim LB, Kent P, Caglar K, et al. Improvement in nutritional parameters after initiation of chronic hemodialysis. Am J Kidney Dis. 2002;40:143–151
  27. Pupim LB, Majchrzak KM, Flakoll PJ, et al. Intradialytic oral nutrition improves protein homeostasis in chronic hemodialysis patients with deranged nutritional status. J Am Soc Nephrol. 2006;17:3149–3157
  28. Higgins JPT: GSe, CochraneHandbook for Systematic Reviews of Interventions. Version 5.0.1 in the Cochrane Collaboration. 2008

PII: S1051-2276(09)00217-9

doi: 10.1053/j.jrn.2009.08.003

Journal of Renal Nutrition
Volume 20, Issue 1 , Pages 1-7 , January 2010

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