Journal of Renal Nutrition
Volume 20, Issue 4 , Pages 224-234 , July 2010

Independent and Joint Associations of Nutritional Status Indicators With Mortality Risk Among Chronic Hemodialysis Patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS)

  • Antonio Alberto Lopes, MD, PhD

      Affiliations

    • Department of Medicine, Federal University of Bahia, Salvador, BA, Brazil
    • Corresponding Author InformationAddress reprint requests to Dr. Antonio Alberto Lopes, Departamento de Medicina da Faculdade de Medicina da Universidade Federal da Bahia, Av. Reitor Miguel Calmon, s/n, Vale do Canela, Salvador, BA - CEP: 40110-100 Brazil.
    • ,
  • Jennifer L. Bragg-Gresham, MS

      Affiliations

    • Arbor Research Collaborative for Health, Ann Arbor, MI 48103
    • ,
  • Stacey J. Elder, MS

      Affiliations

    • Arbor Research Collaborative for Health, Ann Arbor, MI 48103
    • ,
  • Nancy Ginsberg, RD

      Affiliations

    • Renal Research Institute, New York, NY 10128
    • ,
  • David A. Goodkin, MD

      Affiliations

    • Arbor Research Collaborative for Health, Ann Arbor, MI 48103
    • ,
  • Trinh Pifer, MPH

      Affiliations

    • Arbor Research Collaborative for Health, Ann Arbor, MI 48103
    • ,
  • Norbert Lameire, MD

      Affiliations

    • Ghent University Hospital, Ghent, Belgium
    • ,
  • Mark R. Marshall, MBChB

      Affiliations

    • Middlemore Hospital, Auckland, New Zealand
    • ,
  • Yasushi Asano, MD

      Affiliations

    • Koga Red Cross Hospital, Koga, Ibaraki, Japan
    • ,
  • Tadao Akizawa, MD

      Affiliations

    • Showa University Hospital, Shingawa, Tokyo, Japan
    • ,
  • Ronald L. Pisoni, PhD, MS

      Affiliations

    • Arbor Research Collaborative for Health, Ann Arbor, MI 48103
    • ,
  • Eric W. Young, MD, MS

      Affiliations

    • Veterans Affairs Ann Arbor Healthcare System/University of Michigan, Ann Arbor, MI 48105
    • ,
  • Friedrich K. Port, MD, MS

      Affiliations

    • Arbor Research Collaborative for Health, Ann Arbor, MI 48103

References 

  1. Lowrie EG, Huang WH, Lew NL. Death risk predictors among peritoneal dialysis and hemodialysis patients: a preliminary comparison. Am J Kidney Dis. 1995;26:220–228
  2. Kalantar-Zadeh K, Kopple JD. Relative contributions of nutrition and inflammation to clinical outcome in dialysis patients. Am J Kidney Dis. 2001;38:1343–1350
  3. Combe C, McCullough KP, Asano Y, et al. Kidney Disease Outcomes Quality Initiative (K/DOQI) and the Dialysis Outcomes and Practice Patterns Study (DOPPS): nutrition guidelines, indicators, and practices. Am J Kidney Dis. 2004;44:39–46
  4. Pifer TB, McCullough KP, Port FK, et al. Mortality risk in hemodialysis patients and changes in nutritional indicators: DOPPS. Kidney Int. 2002;62:2238–2245
  5. Blumenkrantz MJ, Kopple JD, Gutman RA, et al. Methods for assessing nutritional status of patients with renal failure. Am J Clin Nutr. 1980;33:1567–1585
  6. Kidney Disease Outcome Quality Initiative. Clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis. 2000;35:S1–S140
  7. Depner TA, Daugirdas JT. Equations for normalized protein catabolic rate based on two-point modeling of hemodialysis urea kinetics. J Am Soc Nephrol. 1996;7:780–785
  8. Thijssen S, Wystrychowski G, Usvyat L, et al. Determinants of serum albumin concentration analyzed in a large cohort of patients on maintenance hemodialysis. J Ren Nutr. 2007;17:70–74
  9. Young EW, Goodkin DA, Mapes DL, et al. The Dialysis Outcomes and Practice Patterns Study (DOPPS): an international hemodialysis study. Kidney Int. 2000;57(suppl 74):S74–S81
  10. Pisoni RL, Gillespie BW, Dickinson DM, et al. The Dialysis Outcomes and Practice Patterns Study (DOPPS): design, data elements, and methodology. Am J Kidney Dis. 2004;44:7–15
  11. Gomez D, Morris-Stiff G, Toogood GJ, et al. Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol. 2008;97:513–518
  12. Hsu J, Johansen KL, Hsu CY, et al. Higher serum creatinine concentrations in black patients with chronic kidney disease: beyond nutritional status and body composition. Clin J Am Soc Nephrol. 2008;3:992–997
  13. Fleischmann E, Teal N, Dudley J, et al. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int. 1999;55:1560–1567
  14. Kaysen GA, Dubin JA, Muller HG, et al. Relationships among inflammation nutrition and physiologic mechanisms establishing albumin levels in hemodialysis patients. Kidney Int. 2002;61:2240–2249
  15. Cowie CC, Port FK, Wolfe RA, et al. Disparities in incidence of diabetic end-stage renal disease according to race and type of diabetes. N Engl J Med. 1989;321:1074–1079
  16. Lopes AA, Elder SJ, Ginsberg N, et al. Lack of appetite in haemodialysis patients–associations with patient characteristics, indicators of nutritional status and outcomes in the international DOPPS. Nephrol Dial Transplant. 2007;22:3538–3546
  17. Goodkin DA, Young EW, Kurokawa K, et al. Mortality among hemodialysis patients in Europe, Japan, and the United States: case-mix effects. Am J Kidney Dis. 2004;44:16–21
  18. Mapes DL, Lopes AA, Satayathum S, et al. Health-related quality of life as a predictor of mortality and hospitalization: the Dialysis Outcomes and Practice Patterns Study (DOPPS). Kidney Int. 2003;64:339–349
  19. Leavey SF, McCullough K, Hecking E, et al. Body mass index and mortality in ‘healthier’ as compared with ‘sicker’ haemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant. 2001;16:2386–2394
  20. Lowrie EG, Lew NL. Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis. 1990;15:458–482
  21. Owen WF, Lew NL, Liu Y, et al. The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med. 1993;329:1001–1006
  22. Vanholder R, Van Biesen W. Incidence of infectious morbidity and mortality in dialysis patients. Blood Purif. 2002;20:477–480

 The DOPPS is administered by Arbor Research Collaborative for Health. DOPPS I, II, and III have been supported by research grants from Amgen Inc. and Kyowa Hakko Kirin Co., Ltd. As of January 2009, the DOPPS is additionally funded by Genzyme Corp. Support is provided without restrictions on publications. Friedrich K. Port receives research funding for the DOPPS from Amgen Inc. and Kyowa Hakko Kirin Co Ltd. (additionally since 2009 from Genzyme Corp.). This manuscript was edited by Shauna Leighton, a medical editor employed by Arbor Research Collaborative for Health.

PII: S1051-2276(09)00280-5

doi: 10.1053/j.jrn.2009.10.002

Journal of Renal Nutrition
Volume 20, Issue 4 , Pages 224-234 , July 2010

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