Journal of Renal Nutrition
Volume 20, Issue 3 , Pages 158-168 , May 2010

L-Arginine and Antioxidant Diet Supplementation Partially Restores Nitric Oxide-Dependent Regulation of Phenylephrine Renal Vasoconstriction in Diabetics Rats

  • Israel Coronel, MS

      Affiliations

    • Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
    • ,
  • Monica G. Arellano-Mendoza, DSc

      Affiliations

    • Escuela Superior de Medicina IPN, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico
    • ,
  • Leonardo del Valle-Mondragon, BSc

      Affiliations

    • Instituto Nacional de Cardiología, Mexico City, Mexico
    • ,
  • Hilda Vargas-Robles, DSc

      Affiliations

    • Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
    • ,
  • Fabiola Castorena-Torres, DSc

      Affiliations

    • Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
    • ,
  • Eunice Romo, BSc

      Affiliations

    • Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
    • ,
  • Amelia Rios, BSc

      Affiliations

    • Centro de Investigacion y de Estudios Avanzados del IPN-Monterrey, Monterrey, Mexico
    • ,
  • Bruno Escalante, MD, PhD

      Affiliations

    • Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
    • Centro de Investigacion y de Estudios Avanzados del IPN-Monterrey, Monterrey, Mexico
    • Corresponding Author InformationAddress reprint requests to Bruno Escalante MD, PhD, Department of Molecular Biomedicine, Centro de Investigacion y de Estudios Avanzados del IPN, 07360 Mexico City, Mexico.

References 

  1. Yamagishi S, Imaizumi T. Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. Curr Pharm Des. 2005;11:2279–2299
  2. Bonora E, Muggeo PM. Postprandial blood glucose as a risk factor for cardiovascular disease in type II diabetes: the epidemiological evidence. Diabetologia. 2001;44:2107–2114
  3. Lesniewski LA, Donato AJ, Behnke BJ, et al. Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension. Am J Physiol Heart Circ Physiol. 2008;294:H1840–H1850
  4. Abebe W, Mozaffari MS. Vascular reactivity in glucose-intolerant rat. J Cardiovasc Pharmacol. 2007;50:590–597
  5. Abebe W, Harris KH, Macleod KM. Enhanced contractile responses of arteries from diabetic rats to alpha 1-adrenoreceptor stimulation in the absence and presence of extracellular calcium. J Cardiovasc Pharmacol. 1990;16:239–248
  6. Shi Y, Vanhoutte PM. Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats. Br J Pharmacol. 2008;154:639–651
  7. Okon EB, Chung AWY, Rauniyar P, et al. Compromised arterial function in human type 2 diabetic patients. Diabetes. 2005;54:2415–2423
  8. Sartoretto JL, Oliveira MA, Nigro D, Carvalho MHC, Tostes RC, Fortes ZB. Constrictor responses to noradrenalin, hemodynamic profile and superoxide levels measured by hydroethidine in diabetic rats. Biol Pharm Bull. 1938-1942;30:2007
  9. Sartoretto JL, Melo GA, Carvalho MH, et al. Metformin treatment restores the altered microvascular reactivity in neonatal streptozotocin-induced diabetic rats increasing NOS activity, but not NOS expression. Life Sci. 2005;77:2676–2689
  10. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev. 2002;23:599–622
  11. Tang EH, Leung FP, Huang Y, Feletou M, So KF, Man RYK. Calcium and oxygen species increase in endothelial cells in response to release of endothelium-derived contracting factor. Br. J Pharmacol. 2007;151:15–23
  12. Tesch GH, Allen TJ. Rodent models of streptozotocin-induced nephropathy. Nephrology. 2007;12:261–266
  13. Levere RD, Martasek P, Escalante B, et al. Effect of heme arginate administration on blood-pressure in spontaneously hypertensive rats. J Clin Invest. 1990;86:213–219
  14. Niu Tian KD, Thrasher PD, Gundy MD, Davis Manning RD. Antioxidant treatment prevents renal damage and dysfunction and reduces arterial pressure in salt sensitive hypertension. Hypertension. 2005;45:934–939
  15. Arellano-Mendoza MG, Castillo-Henkel C, Medina-Santillan R, et al. Kidney damage after renal ablation is worsened in endothelial nitric oxide synthase (−/−) mice and improved by combined administration of L-arginine and antioxidants. Nephrology. 2008;13:218–227
  16. Rothe G, Valet G. Flow cytometric analysis of respiratory bursa activity in phagocytes which hydroethidine and 2′,7′-dichlorofluorescein. J Leukocyte Biol. 1995;55:253–258
  17. Heales S, Hyland K. Determination of quinonoid dihydrobiopterin by high-performance liquid chromatography and electrochemical detection. J Chromatogr. 1989;494:77–85
  18. Sanchez-Mendoza A, Hong E, Escalante B. The role of nitric oxide in angiotensin II-induced renal vasoconstriction in renovascular hypertension. J Hypertens. 1998;15:697–703
  19. Breyer MD, Bottinger E, Brosius FC, et al. Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2005;16:27–45
  20. Scmezer P, Ecker C, Liegibel UM. Tissue-specific induction of mutations by streptozotocin in vivo. Mutat Res. 1994;307:495–499
  21. Inada A, Kanamori H, Arai H, et al. A model of diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse. J Cell Physiol. 2008;215:383–391
  22. Hebden RA. Experimental models of diabetes. In:  McNeill JH editors. Boca Raton: CRC Press; 1999;p. 177–193
  23. Esler M, Rumantir M, Wiesner G, Kaye D, Hastings J, Lambert G. Sympathetic nervous system and insulin resistance: from obesity to diabetes. Am J Hypertens. 2004;14(Suppl.):304S–309S
  24. Xiang L, Dearman J, Abram SR, Carter C, Hester RL. Insulin resistance and impaired functional vasodilation in obese Zucker rats. Am J Physiol Heart Circ Physiol. 2008;294:H1658–H1666
  25. Yagishashi N, Nishida N, Geuk SH, Taniguchi N, Yagihashi S. Expression of nitric oxide synthase in macula densa in streptozotocin diabetic rats. Diabetologia. 1996;39:793–799
  26. Cosenzi A, Bernobich E, Bonavita M, Trevisan R, Bellini G, Campanacci L. Early effects of diabetes on inducible nitric oxide synthase in the kidney. Acta Diabetol Lat. 2002;39:91–96
  27. Guzik TJ, Mussa S, Gastaldi D, et al. Mechanism of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation. 2000;105:1656–1662
  28. Settergren M, Bohm F, Malmstrom RE, Channon KM, Pernow J. L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. Atheroesclerosis. 2009;204:73–78

PII: S1051-2276(09)00286-6

doi: 10.1053/j.jrn.2009.10.008

Journal of Renal Nutrition
Volume 20, Issue 3 , Pages 158-168 , May 2010

Article Tools

* Image Usage & Resolution