Journal of Renal Nutrition
Volume 20, Issue 4 , Pages 213-223 , July 2010

Artificial Nutritional Support in Chronic Hemodialysis Patients: A Narrative Review

  • Maurizio Bossola, MD

      Affiliations

    • Hemodialysis Service, Department of Surgery, Catholic University, Rome, Italy
    • Corresponding Author InformationAddress reprint requests to Maurizio Bossola, MD, Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A.Gemelli, 8 00168 Roma, Italia.
  • ,
  • Luigi Tazza, MD

      Affiliations

    • Hemodialysis Service, Department of Surgery, Catholic University, Rome, Italy
  • ,
  • Stefania Giungi, MD

      Affiliations

    • Hemodialysis Service, Department of Surgery, Catholic University, Rome, Italy
  • ,
  • Fausto Rosa, MD

      Affiliations

    • Department of Surgery, Catholic University, Rome, Italy
  • ,
  • Giovanna Luciani, MD

      Affiliations

    • Hemodialysis Service, Department of Surgery, Catholic University, Rome, Italy

References 

  1. Locatelli F, Fouque D, Heimburger O, et al. Nutritional status in dialysis patients: a European consensus. Nephrol Dial Transplant. 2002;17:563–572
  2. Dukkipati R, Kopple JD. Causes and prevention of protein-energy wasting in chronic kidney failure. Semin Nephrol. 2009;29:39–49
  3. Bossola M, Tazza L, Luciani G. Mechanisms and treatment of anorexia in end-stage renal disease patients on hemodialysis. J Ren Nutr. 2009;19:2–9
  4. Mehrotra R, Berman N, Alistwani A, et al. Improvement of nutritional status after initiation of maintenance hemodialysis. Am J Kidney Dis. 2002;40:133–142
  5. Pupim LB, Kent P, Caglar K, et al. Improvement in nutritional parameters after initiation of chronic hemodialysis. Am J Kidney Dis. 2002;40:143–151
  6. Bossola M, Muscaritoli M, Tazza L, et al. Malnutrition in hemodialysis patients: what therapy?. Am J Kidney Dis. 2005;46:371–386
  7. Kuhlmann MK, Scmidt F, Kohler H. Oral nutritional support in malnourished patients on HD: preliminary results of a randomised controlled study (abstract). J Am Soc Nephrol. 1997;8:199A
  8. Cockhram DB, Hensley MK, Rodriguez M, et al. Safety and tolerance of medical nutritional products as sole sources of nutrition in people on hemodialysis. J Ren Nutr. 1998;8:25–33
  9. Sharma M, Rao M, Jacob S, Jacob CK. A controlled trial intermittent enteral nutrient supplementation in maintenance hemodialysis patients. J Ren Nutr. 2002;12:229–237
  10. Fouque D, McKenzie J, de Mutsert R, et al. and the Renilon Multicentre Trial Study Group Use of a renal-specific oral supplement by haemodialysis patients with low protein intake does not increase the need for phosphate binders and may prevent a decline in nutritional status and quality of life. Nephrol Dial Transplant. 2008;23:2902–2910
  11. Cuppari L, Medeiros FA, Papini HF, et al. Effectiveness of oral energy-protein supplementation in severely malnourished hemodialysis patients. J Renal Nutr. 1994;4:127–135
  12. Beutler KT, Park GK, Wilkowsky MJ. Effect of oral supplementation on nutrition indicators in hemodialysis patients. J Ren Nutr. 1997;7:77–82
  13. Shah NA, Mueller BA, Thomas J, et al. Effects of supplemental enteral nutrition on nutritional status and quality of life in ESRD patients receiving hemodialysis. (abstract) J Am Soc Nephrol. 1999;10:303A
  14. Patel MG, Kitchen S, Milligan PJ. Effect of dietary supplements on the nPCR in stable hemodialysis patients. J Ren Nutr. 2000;10:69–75
  15. Wilson B, Fernandez-Madrid A, Hayes A, et al. Comparison of the effects of two early intervention strategies on the health outcomes of malnourished hemodialysis patients. J Ren Nutr. 2001;11:166–171
  16. Caglar K, Fedje L, Dimmitt R, et al. Therapeutic effects of oral nutritional supplementation during hemodialysis. Kidney Int. 2002;62:1054–1059
  17. Steiber AL, Handu DJ, Cataline DR, et al. The impact of nutrition intervention on a reliable morbidity and mortality indicator: the hemodialysis-prognostic nutrition index. J Ren Nutr. 2003;13:186–190
  18. Scott MK, Shah NA, Vilay AM, et al. Effects of peridialytic oral supplements on nutritional status and quality of life in chronic hemodialysis patients. J Ren Nutr. 2009;19:145–152
  19. Ewers B, Riserus U, Marckmann P. Effects of unsaturated fat dietary supplements on blood lipids and on markers of malnutrition and inflammation in hemodialysis patients. J Ren Nutr. 2009;19:401–411
  20. Acchiardo SR, Riley ML. Five years' experience with oral nutritional supplements (ONS) in hemodialysis (HD) patients. Are they useful (abstract)?. J Am Soc Nephrol. 2002;13:415A
  21. Mastroiacovo P, Pace V, Sagliaschi G. Aminoacids for dialysis patients. Clin Ther. 1993;15:698–704
  22. Eustace JA, Coresh J, Kutchey C, et al: Randomized double-blind trial of oral essential amino acids for dialysis-associated hypoalbuminemia. Kidney Int 2000;57: 2527–2538, 2000
  23. Hiroshige K, Sonta T, Suda T, et al. Oral supplementation of branched-chain amino acid improves nutritional status in elderly patients on chronic hemodialysis. Nephrol Dial Transplant. 2001;16:1856–1862
  24. Pupim L, Flakoll PJ, Broillette JR, et al. Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J Clin Invest. 2002;110:483–492
  25. Pupim L, Flakoll PJ, Ikizler TA. Nutritional supplementation acutely increases albumin fractional synthetic rate in chronic hemodialysis patients. J Am Soc Nephrol. 2004;15:1920–1926
  26. Pupim L, Flakoll PJ, Levenhagen DK, et al. Exercise augments the acute anabolic effects of intradialytic parenteral nutrition in chronic hemodialysis patients. Am J Physiol Endocrinol Metab. 2004;286:E589–E597
  27. Snyder S, Bergen C, Sigler MH, et al. Intradialytic parenteral nutrition in chronic hemodialysis patients. ASAIO Trans. 1991;37:M373–M375
  28. Schulman G, Wingard RL, Hutchinson RL, et al. The effects of recombinant human growth hormone and intradialytic parenteral nutrition in malnourished hemodialysis patients. Am J Kidney Dis. 1993;21:527–534
  29. Hiroshige K, Iwamoto M, Kabashima N, et al. Prolonged use of intradialysis parenteral nutrition in elderly malnourished chronic hemodialysis patients. Nephrol Dial Transplant. 1998;13:2081–2087
  30. Mortelmans AK, Duym P, Vandenbroucke J, et al. Intradialytic parenteral nutrition in malnourished hemodialysis patients: a prospective long-term study. JPEN. 1999;23:90–95
  31. Berneis K, Iseli-Scahub J, Garbani E, et al. Effects of intradialytic parenetral nutrition in chronic hemodialysis patients with malnutrition: a pilot study. Wien Klin Wochenschr. 1999;12:876–881
  32. Krause I, Shamir R, Davidovits M, et al. Intradialytic parenteral nutrition in malnourished children treated with hemodialysis. J Ren Nutr. 2002;12:55–59
  33. Cherry N, Shalansky K. Efficacy of intradialytic parenteral nutrition in malnourished hemodialysis patients. Am J Health Syst Pharm. 2002;15:1736–1741
  34. Czekalski S, Hozejowski R. Intradialytic aminoacids supplementation in hemodialysis patients with malnutrition: results of a multicenter cohort study. J Ren Nutr. 2004;14:82–88
  35. Orellana P, Juarez-Congelosi M, Goldstein SL. Intradialytic parenteral nutrition treatment and biochemical marker assessment for malnutrition in adolescent maintenance hemodialysis patients. J Ren Nutr. 2005;15:312–317
  36. Joannindis M, Rauchenzauner M, Leiner B, et al. Effect of intradialytic parenteral nutrition in patients with malnutrition-inflammation complex syndrome on body weight, inflammation, serum lipids and adipocytokines: results of a pilot study. Eur J Clin Nutr. 2008;62:789–795
  37. Dezfuli A, Scholl D, Lindenfeld SM, et al. Severity of hypoalbuminemia predicts response to intradialytic parenteral nutrition in hemodialysis patients. J Ren Nutr. 2009;19:291–297
  38. Foulks CJ. The effect of intradialytic parenteral nutrition on hospitalization rate and mortality in malnourished hemodialysis patients. J Ren Nutr. 1994;4:5–10
  39. Capelli JP, Kushner H, Camiscioli TC, et al. Effect of intradialytic parenteral nutrition on mortality rates in end-stage renal disease care. Am J Kidney Dis. 1994;23:808–816
  40. Chertow GM, Ling J, Lew NL, et al. The association of intradialytic parenteral nutrition administration with survival in hemodialysis patients. Am J Kidney Dis. 1994;24:912–920
  41. Cano NJM, Fouque D, Roth H, et al. the French Study Group for Nutrition in Dialysis. Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients: a 2-year multicenter, prospective, randomised study. J Am Soc Nephrol. 2007;18:2583–2591
  42. Siskind MS, Lien YH. Effect of intradialytic parenteral nutrition on quality of life in hemodialysis patients. Int J Artif Organs. 1993;16:599–603

PII: S1051-2276(10)00007-5

doi: 10.1053/j.jrn.2010.01.006

Journal of Renal Nutrition
Volume 20, Issue 4 , Pages 213-223 , July 2010