Adiponectin, Resistin and Leptin Response to Dietary Intervention in Diabetic Nephropathy

Kozłowska, Lucyna; Rydzewski, Andrzej; Fiderkiewicz, Bartosz; Wasińska-Krawczyk, Anna; Grzechnik, Agnieszka; Rosołowska-Huszcz, Danuta

doi:10.1053/j.jrn.2010.01.009

« Previous Next »Journal of Renal Nutrition
Volume 20, Issue 4 , Pages 255-262, July 2010

Adiponectin, Resistin and Leptin Response to Dietary Intervention in Diabetic Nephropathy

Lucyna Kozłowska, PhD
- Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, Warsaw, Poland
- Address reprint requests to Lucyna Kozłowska, Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland.
Andrzej Rydzewski, MD, PhD
- Department of Internal Medicine and Nephrology, Central Clinical Hospital of The Ministry of Internal Affairs and Administration, Warsaw, Poland
- Institute of Medical Education, Jan Kochanowski University, Kielce, Poland
Bartosz Fiderkiewicz, MD
- Department of Internal Medicine and Nephrology, Central Clinical Hospital of The Ministry of Internal Affairs and Administration, Warsaw, Poland
Anna Wasińska-Krawczyk, MD
- Department of Internal Medicine and Nephrology, Central Clinical Hospital of The Ministry of Internal Affairs and Administration, Warsaw, Poland
Agnieszka Grzechnik
- Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, Warsaw, Poland
Danuta Rosołowska-Huszcz, PhD
- Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, Warsaw, Poland

published online 31 May 2010.

Objective

Adipokines play an important role in metabolic regulations. Obesity, diabetes, and renal disturbances affect adipokine profile by influencing their complex effects on metabolism. Our objective was to assess the effect of low-energy diet intervention on serum adiponectin, leptin, and resistin levels in diabetic nephropathy.

Methods

Seventeen subjects with diabetes type 2 and nephropathy participated in the study. After estimation of individual resting metabolic rates by indirect calorimetry, diets introducing 20% energy deficit were applied. At baseline and after 2 months of dieting, the following parameters were measured: body composition by dual x-ray spectrometry and serum adiponectin (Adp), leptin (Lep), resistin (Res), insulin, urea, creatinine, glucose, glycosylated hemoglobin, C-reactive protein, and tumor necrosis factor-α concentrations. Homeostatic model assessment (HOMA) was used to quantify insulin resistance.

Results

Total energy, protein, and fat intakes diminished significantly with intentional dieting. Significant decreases in total body fat mass (FM) and its percentage in body mass (FM%) and trunk and gynoid fat mass, as well as in serum resistin and tumor necrosis factor-α levels, were also observed. Responses of adipokines to dietary treatment varied individually. Generally, they were affected by FM. Alterations in Lep concentrations correlated negatively with baseline FM, FM%, and android and gynoid fat mass and positively with changes in intake of protein, carbohydrates, and total energy of the consumed diet. Changes in Adp were inversely related to FM after therapy. Alterations in Res concentrations correlated positively with android fat mass before therapy and initial Lep levels. Adiponectin was inversely related to HOMA index before and after treatment.

Conclusions

Low-energy diet applied in diabetic nephropathy may decrease serum resistin levels and inflammation. In addition, responses of all adipokines to dieting appear to be affected by body fat mass, especially android fat mass.