Journal of Renal Nutrition
Volume 20, Issue 6 , Pages 408-413 , November 2010

Megestrol Acetate Improves Weight Gain in Pediatric Patients With Chronic Kidney Disease

This study was presented at the 2009 American Society of Pediatric Nephrology meeting, Baltimore, MD.

  • David J. Hobbs, MBSc

      Affiliations

    • Pediatric Nephrology, Dialysis and Transplantation, Helen DeVos Children's Hospital and Michigan State University College of Human Medicine, Grand Rapids, MI
    • ,
  • Timothy E. Bunchman, MD

      Affiliations

    • Pediatric Nephrology, Dialysis and Transplantation, Helen DeVos Children's Hospital and Michigan State University College of Human Medicine, Grand Rapids, MI
    • ,
  • David P. Weismantel, MD, MS

      Affiliations

    • Department of Family Medicine, Michigan State University College of Human Medicine, East Lansing, MI
    • ,
  • Morgan R. Cole, PharmD

      Affiliations

    • Department of Pharmacy, Helen DeVos Children's Hospital, Grand Rapids, MI
    • ,
  • Karen B. Ferguson, RD, CNSD

      Affiliations

    • Pediatric Nephrology, Dialysis and Transplantation, Helen DeVos Children's Hospital and Michigan State University College of Human Medicine, Grand Rapids, MI
    • ,
  • Tracy R. Gast, RD

      Affiliations

    • Pediatric Nephrology, Dialysis and Transplantation, Helen DeVos Children's Hospital and Michigan State University College of Human Medicine, Grand Rapids, MI
    • ,
  • Gina-Marie Barletta, MD

      Affiliations

    • Pediatric Nephrology, Dialysis and Transplantation, Helen DeVos Children's Hospital and Michigan State University College of Human Medicine, Grand Rapids, MI
    • Corresponding Author InformationAddress reprint requests to Gina-Marie Barletta, MD, Pediatric Nephrology, Dialysis and Transplantation, Helen DeVos Children's Hospital, 221 Michigan Street NE, Suite 406, Grand Rapids, MI 49503.

References 

  1. Graf L, Candelaria S, Doyle M, et al. Nutrition assessment and hormonal influences on body composition in children with chronic kidney disease. Adv Chronic Kidney Dis. 2007;14(2):215–223
  2. Silverstein DM. Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular disease. Pediatr Nephrol. 2009;24(8):1445–1452
  3. KDOQI Clinical Practice Guideline for Nutrition in Children with CKD: 2008 Update. Am J Kidney Dis. 2009;53:S1–124
  4. Bossola M, Muscaritoli M, Tazza L, et al. Malnutrition in hemodialysis patients: what therapy?. Am J Kidney Dis. 2005;46(3):371–386
  5. Loprinzi CL, Jensen MD, Jiang NS, et al. Effect of megestrol acetate on the human pituitary-adrenal axis. Mayo Clin Proc. 1992;67:1160–1162
  6. Meacham LR, Mazewski C, Krawiecki N. Mechanism of transient adrenal insufficiency with megestrol acetate treatment of cachexia in children with cancer. J Pediatr Hematol Oncol. 2003;25(5):414–417
  7. Naing KK, Dewar JA, Leese GP. Megestrol acetate therapy and secondary adrenal suppression. Cancer. 1999;86:1044–1049
  8. Chidakel AR, Zweig SB, Schlosser JR, et al. High prevalence of adrenal suppression during acute illness in hospitalized patients receiving megestrol acetate. J Endocrinol Invest. 2006;29(2):136–140
  9. Daaboul JJ, Yogev R, Scully SP, et al. Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate. J Pediatr. 1999;134:368–370
  10. Dev R, Del Fabbro E, Bruera E. Association between megestrol acetate treatment and symptomatic adrenal insufficiency with hypogonadism in male patients with cancer. Cancer. 2007;110(6):1173–1177
  11. Mann M, Koller E, Murgo A, et al. Glucocorticoidlike activity of megestrol. A summary of Food and Drug Administration experience and a review of the literature. Arch Intern Med. 1997;157(15):1651–1656
  12. Loprinzi CL, Ellison NM, Schaid DJ, et al. Controlled trial of megestrol acetate for the treatment of cancer anorexia and cachexia. J Natl Cancer Inst. 1990;82(13):1127–1132
  13. Vadell C, Seguí MA, Giménez-Arnau JM, et al. Anticachectic efficacy of megestrol acetate at different doses and versus placebo in patients with neoplastic cachexia. Am J Clin Oncol. 1998;21(4):347–351
  14. Von Roenn JH, Armstrong D, Kotler DP, et al. Megestrol acetate in patients with AIDS-related cachexia. Ann Intern Med. 1994;121(6):393–399
  15. Azcona C, Castro L, Crespo E, et al. Megestrol acetate therapy for anorexia and weight loss in children with malignant solid tumors. Aliment Pharmacol Ther. 1996;10:577–586
  16. Marchand V, Baker SS, Stark TJ, et al. Randomized, double-blind, placebo-controlled pilot trial of megestrol acetate in malnourished children with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2002;31(3):264–269
  17. Eubanks V, Koppersmith N, Wooldridge N, et al. Effects of megestrol acetate on weight gain, body composition, and pulmonary function in patients with cystic fibrosis. J Pediatr. 2002;140(4):439–444
  18. Clarick RH, Hanekom WA, Yogev R, et al. Megestrol acetate treatment of growth failure in children infected with human immunodeficiency virus. Pediatrics. 1997;99(3):354–357
  19. Jara LJ, Navarro C, Medina G, Vera-Lastra O, et al. Immune-neuroendocrine interactions and autoimmune diseases. Clin Dev Immunol. 2006;13(2-4):109–123
  20. Schwartz GJ, Haycock GB, Edelmann CM, et al. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976;58(2):259–263
  21. Sylvestre LC, Fonseca KP, Stinghen AE, et al. The malnutrition and inflammation axis in pediatric patients with chronic kidney disease. Pediatr Nephrol. 2007;22:864–873
  22. Wong CS, Hingorani S, Gillen DL, et al. Hypoalbuminemia and risk of death in pediatric patients with end-stage renal disease. Kidney Int. 2002;61:630–637
  23. Bodenner DL, Medhi M, Evans WJ, et al. Effects of megestrol acetate on pituitary function and end-organ hormone secretion: a post hoc analysis of serum samples from a 12-week study in healthy older men. Am J Geriatr Pharmacother. 2005;3(3):160–167
  24. Romeo RD, Bellani R, Karatsoreos IN, et al. Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticity. Endocrinology. 2006;147(4):1664–1674

 D.J.H. is supported by an American Society of Nephrology Student Scholar Grant.

PII: S1051-2276(10)00011-7

doi: 10.1053/j.jrn.2010.01.010

Journal of Renal Nutrition
Volume 20, Issue 6 , Pages 408-413 , November 2010

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