Journal of Renal Nutrition
Volume 21, Issue 2 , Pages 149-159 , March 2011

The Effect of Resistance Exercise to Augment Long-term Benefits of Intradialytic Oral Nutritional Supplementation in Chronic Hemodialysis Patients

  • Jie Dong, MD, PhD

      Affiliations

    • Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
    • Division of Nephrology, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China
  • ,
  • Mary B. Sundell, RD

      Affiliations

    • Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Lara B. Pupim, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Pingsheng Wu, PhD

      Affiliations

    • Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Ayumi Shintani, PhD

      Affiliations

    • Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • T. Alp Ikizler, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
    • Corresponding Author InformationAddress reprint requests to T. Alp Ikizler, MD, Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Ave. South & Garland, S-3223 MCN, Nashville, TN 37232-2372.

  • Image Result

    Trial flow chart (NS, nutrition supplementation; NS + EX, nutrition supplementation plus resistance exercise).

    Trial flow chart (NS, nutrition supplementation; NS + EX, nutrition supplementation plus resistance exercise).

  • Image Result

    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and the line within t

    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and the line within the box represents the median) of the total lean body mass as measured by dual-energy X-ray absorptiometry (DEXA) at baseline, 3 month and 6 month of follow-up. P value comparing the 2 treatments over time was obtained from the general linear model with bootstrap covariance accounting for correlated measures within a subject.

  • Image Result
    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond th

    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond the whiskers are extreme values, the line within the box represents the median) of the leg lean mass measured by DEXA at baseline, 3 month, and 6 month of follow-up. P value comparing the 2 treatments over time was obtained from the general linear model with bootstrap covariance accounting for correlated measures within a subject.

  • Image Result
    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond th

    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond the whiskers are extreme values, the line within the box represents the median) of the lean body mass as percentage of body weight measured by DEXA at baseline, 3 month, and 6 month of follow-up. P value comparing the 2 treatments over time was obtained from the general linear model with bootstrap covariance accounting for correlated measures within a subject.

  • Image Result
    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond th

    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond the whiskers are extreme values, the line within the box represents the median) of the leg lean mass as percentage of body weight measured by DEXA at baseline, 3 month, and 6 month of follow-up. P value comparing the 2 treatments over time was obtained from the general linear model with bootstrap covariance accounting for correlated measures within a subject.

  • Image Result
    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond th

    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond the whiskers are extreme values, the line within the box represents the median) of body weight measured by DEXA at baseline, 3 month, and 6 month of follow-up. P value showing the changes over time in the whole cohort adjusted for treatment effect was obtained from the general linear model with bootstrap covariance accounting for correlated measures within a subject.

  • Image Result
    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond th

    Box and whisker plot (box represents the interquartile range, whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box, and circles beyond the whiskers are extreme values, the line within the box represents the median) of one-repetition maximum at baseline, 3 month, and 6 month of follow-up. P value showing the changes over time in the whole cohort adjusted for treatment effect was obtained from the general linear model with bootstrap covariance accounting for correlated measures within a subject.

 This study was supported in part by R01 DK45604, K24 DK62849 from the National Institute of Diabetes, Digestive and Kidney Diseases and Clinical Translational Science Award 1UL-1RR024975 from the National Center for Research Resources.

 L.B.P. is currently an employee of Mitsubishi Tanabe Pharma Development America and declares no conflict of interest with regard to involvement with commercial entities that supply nutritional supplements.

PII: S1051-2276(10)00075-0

doi: 10.1053/j.jrn.2010.03.004

Journal of Renal Nutrition
Volume 21, Issue 2 , Pages 149-159 , March 2011