Journal of Renal Nutrition
Volume 20, Issue 6 , Pages 359-367 , November 2010

Vitamin D Deficiency in Dialysis Patients: Effect of Dialysis Modality and Implications on Outcome

  • Carolina Gracia-Iguacel, MD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Paloma Gallar, MD, PhD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Abdul R. Qureshi, MD, PhD

      Affiliations

    • Division of Renal Medicine and Baxter Novum, CLINTEC, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Olimpia Ortega, PhD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Carmen Mon, PhD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Milagros Ortiz, MD, PhD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Isabel Villarreal, PhD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Concepcion Garcia-Lacalle, PhD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Aniana Olieta, MD, PhD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Maria Sánchez

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Juan C. Herrero, MD, PhD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Ana Vigil, MD, PhD

      Affiliations

    • Division of Renal Medicine, Severo Ochoa University Hospital, Madrid, Spain
    • ,
  • Beng Lindholm, MD, PhD

      Affiliations

    • Division of Renal Medicine and Baxter Novum, CLINTEC, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Juan J. Carrero, PhD

      Affiliations

    • Division of Renal Medicine and Baxter Novum, CLINTEC, Karolinska Institutet, Stockholm, Sweden
    • Centre for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    • Centre for Gender Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    • Corresponding Author InformationAddress reprint requests to Juan Jesús Carrero, PhD Pharm, PhD Med, K56, Division of Renal Medicine and Baxter Novum, CLINTEC, Karolinska University Hospital at Huddinge, 14186 Stockholm, Sweden.

  • Image Result

    Distribution of vitamin D levels among 115 prevalent dialysis patients. Vertical dotted lines delineate the range of deficiency (5 to 15 ng/mL), insufficiency (>15 to 30 ng/mL), and normal (>30 ng/mL)

    Distribution of vitamin D levels among 115 prevalent dialysis patients. Vertical dotted lines delineate the range of deficiency (5 to 15 ng/mL), insufficiency (>15 to 30 ng/mL), and normal (>30 ng/mL) vitamin D levels according to the current KDOQI guidelines.19

  • Image Result
    25(OH)D levels according to dialysis technique in 115 prevalent dialysis patients. The 25(OH)D levels were lower in PD patients as compared with hemodialysis patients (on-line hemodiafiltration [OL-HD

    25(OH)D levels according to dialysis technique in 115 prevalent dialysis patients. The 25(OH)D levels were lower in PD patients as compared with hemodialysis patients (on-line hemodiafiltration [OL-HDF] and conventional hemodialysis [HD] combined). At the same time, 25(OH)D levels were significantly higher in patients treated by OL-HDF as compared with those treated by conventional HD.

  • Image Result
    Spearman's Rank correlation test between 25(OH)D and parathyroid hormone (PTH; Panel A) and pH (Panel B).

    Spearman's Rank correlation test between 25(OH)D and parathyroid hormone (PTH; Panel A) and pH (Panel B).

  • Image Result
    Kaplan–Meier according to 25(OH)D insufficiency in 115 prevalent dialysis patients.

    Kaplan–Meier according to 25(OH)D insufficiency in 115 prevalent dialysis patients.

 BL is employed by Baxter Healthcare Inc. None of the other authors have any other conflict of interest.

PII: S1051-2276(10)00076-2

doi: 10.1053/j.jrn.2010.03.005

Journal of Renal Nutrition
Volume 20, Issue 6 , Pages 359-367 , November 2010

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