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IFC
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Uremia Research and Toxicity
WE ARE PLEASED to provide the readers of the Journal of Renal Nutrition with the Proceedings of the Sixth International Congress on Uremia Research and Toxicity, which was held in Poiana Brasov, Roman...
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Shaul G. Massry,
Gabriel Mircescu,
Boleslaw Rutkowski,
Toshimitsu Niwa
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S1
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Indoxyl Sulfate Is a Nephro-Vascular Toxin
Indoxyl sulfate is markedly accumulated in the serum of patients with chronic kidney disease (CKD). The oral sorbent AST-120 reduces the serum levels of indoxyl sulfate in CKD patients by adsorbing in...
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Toshimitsu Niwa
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S2-S6
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Distribution of Purine Nucleotides in Uremic Fluids and Tissues
There are almost 100 different substances called uremic toxins. In this study, we analyze all findings concerning the new family of uremic compounds—nicotinamide end products: N-methyl-2-pyridone-5-ca...
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Bolesław Rutkowski,
Przemysław Rutkowski,
Ewa Słomińska,
Julian Świerczyński
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S7-S10
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Hydrogen Sulfide, the Third Gaseous Signaling Molecule With Cardiovascular Properties, Is Decreased in Hemodialysis Patients
Hydrogen sulfide, H2S, is the third endogenous gas with cardiovascular properties, after nitric oxide and carbon monoxide. H2S is a potent vasorelaxant, and its deficiency is implicated in the pathoge...
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Alessandra F. Perna,
Maria Grazia Luciano,
Diego Ingrosso,
Ilaria Raiola,
Paola Pulzella,
Immacolata Sepe,
Diana Lanza,
Eleonora Violetti,
Rosanna Capasso,
Cinzia Lombardi,
Natale G. De Santo
et al.
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S11-S14
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Novel Kidney Injury Biomarkers
New biomarkers are currently under development for acute kidney injury and chronic kidney disease. Panels of validated biomarkers are most likely to be required to obtain information that will help in...
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Sharon Adler
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S15-S18
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Metabolic Syndrome and Chronic Kidney Disease
Obesity is a global health threat because of its associated metabolic and cardiovascular complications. Metabolic and hemodynamic complications of obesity (insulin resistance and hyperglycemia, hypert...
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Gianfranco Guarnieri,
Michela Zanetti,
Pierandrea Vinci,
Maria Rosa Cattin,
Alesia Pirulli,
Rocco Barazzoni
et al.
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S19-S23
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Muscle Atrophy in Chronic Kidney Disease Results From Abnormalities in Insulin Signaling
Muscle atrophy is a significant consequence of chronic kidney disease that increases a patient's risk of mortality and decreases their quality of life. The loss of lean body mass results, in part, fro...
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S. Russ Price,
Jennifer L. Gooch,
Sue K. Donaldson,
Tiffany K. Roberts-Wilson
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S24-S28
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Obesity and Chronic Kidney Disease
Obesity is a common contributing factor to the development of chronic kidney disease (CKD). Obesity participates in the genesis of CKD by predisposing to diabetic nephropathy, hypertensive nephroscler...
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Joel D. Kopple
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S29-S30
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Nutritional Intervention in Uremia—Myth or Reality?
Nutritional intervention in uremia, specifically the restricted protein diet, has been under debate for decades. The results of various clinical trials have not been concordant, as some studies have r...
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Liliana Garneata,
Gabriel Mircescu
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S31-S34
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Lipotoxicity and Impaired High Density Lipoprotein-Mediated Reverse Cholesterol Transport in Chronic Kidney Disease
Chronic kidney disease (CKD) is associated with a high risk of death from cardiovascular disease. Inflammation, oxidative stress, and dyslipidemia, which are common consequences of CKD, contribute to ...
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Nosratola D. Vaziri
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S35-S43
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Mechanisms of Acute Uremic Encephalopathy: Early Activation of Fos and Fra-2 Gene Products in Different Nuclei/Areas of the Rat Brain
High levels of various uremic toxins such as guanidino compounds and advanced glycation endproducts, as well as an excess of parathyroid hormones, are involved in the pathogenesis of acute uremic ence...
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August Heidland,
Katarina Sebekova,
André Klassen,
Miklós Palkovits
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S44-S50
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A Controlled Study of Psychiatric Manifestations and Electroencephalography Findings in Chronic Kidney Disease Patients With Sagliker Syndrome
Sagliker syndrome (SS) is a novel syndrome that was described in 2004 in patients with chronic kidney disease (CKD). The aim of this study was to assess psychiatric evaluations and electroencephalogra...
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Yarkın Ozenli,
Semih Giray,
Yahya Sagliker,
Siddik M. Adam
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S51-S55
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Audiological Findings in Chronic Kidney Disease Patients With Sagliker Syndrome
Potential hearing loss was found to be high in a 10 patients with chronic kidney disease and Sagliker syndrome. The cause of hearing loss in these subjects remains unknown. We do not know whether thos...
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Alper N. Erkan,
Yahya Sagliker,
Ismail Yildiz,
Levent Ozluoglu
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S56-S58
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A Longitudinal Study of Sleep Disorders in Early-Stage Chronic Kidney Disease
Few studies have addressed the problem of sleep disturbances in patients with early-stage chronic kidney disease (CKD). A total of 220 patients newly diagnosed with CKD and 220 patients newly diagnose...
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Rosa M. De Santo,
Giancarlo Bilancio,
Domenico Santoro,
Maurizio L. Vecchi,
Alessandra Perna,
Natale G. De Santo,
Massimo Cirillo
et al.
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S59-S63
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The High Prevalence of Alexithymia in Hemodialyzed Patients With Secondary Hyperparathyroidism Unsuppressed by Medical Therapy Is Cured by Parathyroidectomy
There are scanty data available on alexithymia in patients with end-stage renal disease, which point to an independent association with depression and social support. This study was devised to investi...
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Rosa Maria De Santo,
Antonio Livrea,
Natale G. De Santo,
Giovanni Conzo,
Giancarlo Bilancio,
Salvatore Celsi,
Massimo Cirillo
et al.
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S64-S70
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Oxidative Stress, Renal Anemia, and Its Therapies: Is There a Link?
In chronic kidney disease, anemia and oxidative stress are common features and both are involved in increasing morbidity and mortality. However, their relationship is still a matter of debate. This ar...
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Cristina Căpuşă,
Gabriel Mircescu
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S71-S76
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Is Hepcidin-25 a Clinically Relevant Parameter for the Iron Status in Hemodialysis Patients?
Background: Accumulating data suggest potential clinical relevant relationships between hepcidin-25 levels, iron stores, erythropoiesis effectiveness, and epoetin dose. The immunometric methods and ma...
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Lavinia O. Brătescu,
Liliana Bârsan,
Dan Munteanu,
Simona Stancu,
Gabriel Mircescu
et al.
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S77-S83
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Red Cell Survival: Relevance and Mechanism Involved
Red blood cells (RBCs) often have a short circulating half-life in hemodialysis patients, which increases the difficulty of achieving a stable hemoglobin level. Fluctuations in erythropoietin (EPO) le...
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Garry J. Handelman,
Nathan W. Levin
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S84-S88
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Skin Blood Flow in Patients With Stage 5 Chronic Kidney Disease on Hemodialysis
We have shown previously that skin perfusion is reduced in patients with diabetes mellitus (DM). Patients with diabetes and with chronic kidney disease (CKD) stage 5 were having advanced microangiopat...
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Binh Ngo,
Christine Rongey,
Bryan Hiscox,
Marc Rendell,
David Woodley,
Miroslaw Smogorzewski
et al.
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S89-S94
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Vitamin B6 and Oxalic Acid in Clinical Nephrology
Objective: Vitamin B6 (VB6) is a water-soluble vitamin, which is important for the normal functioning of multiple organ systems. It is metabolized to the active molecule pyridoxal-5-phosphate (PLP). O...
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Miroslav Mydlík,
Katarína Derzsiová
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S95-S102
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Endothelial Dysfunction in Chronic Renal Failure
Cardiovascular disease is a very early phenomenon in the course of chronic renal failure, and increases continuously with decrease of renal function. Endothelial dysfunction seems to be a starting poi...
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Domenico Santoro,
Guido Bellinghieri,
Giovanni Conti,
Dario Pazzano,
Ersilia Satta,
Giuseppe Costantino,
Vincenzo Savica
et al.
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S103-S108
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Tuberculin Skin Test, Interferon-gamma Assay, and T Cells Subpopulations in Hemodialysis Patients
Objective: To examine and compare the responses of hemodialysis (HD) patients to Mycobacterium tuberculosis antigens by using the tuberculin skin test (TST) and an interferon γ assay (IFN-TB), and to ...
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Ligia Petrescu,
Simona Stancu,
Gratiela Tardei,
Caterina Santimbrean,
Mircea Penescu,
Gabriel Mircescu
et al.
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S109-S117
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The Effect of Type and Vascular Access Quality on the Outcome of Chronic Hemodialysis Treatment
The function of vascular access has a key significance in hemodialysis treatment results. An overview of factors contributing to successful arteriovenous fistula (AVF) constructions and the effect of ...
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Krzysztof Letachowicz,
Wacław Weyde,
Waldemar Letachowicz,
Marian Klinger
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S118-S121
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Progress Toward Novel Treatments for Chronic Kidney Disease
Chronic kidney failure remains a major health problem worldwide. Although current treatment is focused on the renin–angiotensin system, it is essential that new treatments targeted toward novel pathop...
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Sudhir V. Shah
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S122-S126
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Why We Need Clinical Practice Guidelines in Chronic Kidney Disease
Clinical practice guidelines (CPGs) have become an essential, useful, and integral part of the practice of medicine in general and for the care of patients with chronic kidney disease (CKD) in particu...
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Garabed Eknoyan
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S127-S130
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Uremia (End-Stage Renal Disease): How Cost-Effective are Preventive Strategies?
Many strategies have been shown to be cost-effective for prevention of end-stage renal disease (ESRD), most often by Markov modeling using assumptions based on randomized clinical trails and observati...
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Richard J. Glassock
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S131-S134
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Editorial Board
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A1
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Table of Contents
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A3-A4
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